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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9157 | GP130 receptor agonist-1 | N-(4-Fluorophenyl)-4-phenyl-2-thiazolami | Interleukin |
GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist. | |||
T2544 | Bazedoxifene acetate | WAY-TES 424,TSE 424,WAY-140424 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM). | |||
T6404 | Bazedoxifene hydrochloride | Bazedoxifene HCl,TSE-424 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively. | |||
T6207 | SC144 | Apoptosis , Interleukin | |
SC144 is an orally active small-molecule gp130 inhibitor. | |||
T5359 | RCGD423 | Interleukin | |
RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair. | |||
T77672 | JI069 | WAY-354189 | JAK , STAT |
JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1. | |||
T15769 | LMT-28 | IL Receptor | |
LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2. | |||
T41260 | SC144 hydrochloride | ||
SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation... | |||
T72754 | JAK2/STAT3-IN-1 | ||
JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 µM and demonstrating anti-tumor activity. | |||
T19728 | SPRC | S-Propargyl-cysteine | |
SPRC is a novel synthetic molecule exerting antioxidant effects via elevating the generation of endogenous H2S. SPRC activates Gp130-mediated STAT3 and prevents doxorubicin-induced cardiotoxicity. | |||
T74734 | Truncated ADR58 | ||
Truncated ADR58, derived by shortening full-length ADR58 from 71 bases to 31 bases, maintains comparable functional activity to its full-length counterpart. This compound acts as a potent and selective antagonist of huma... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01076 | gp130/IL6ST Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
gp130/IL6ST Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 96 kDa and the accession number is P40189-1. | |||
TMPY-01832 | gp130/IL6ST Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
gp130/IL6ST Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is Q00560. | |||
TMPK-00646 | gp130/IL6ST Protein, Rhesus macaque, Recombinant (His) | Rhesus | HEK293 Cells |
gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa... | |||
TMPY-06745 | gp130/IL6ST Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
gp130/IL6ST Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 94.11 kDa and the accession number is AAA59155.1. | |||
TMPY-00387 | gp130/IL6ST Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
gp130/IL6ST Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 94.4 kDa and the accession number is AAA59155.1. | |||
TMPK-00412 | gp130/IL6ST Protein, Human, Recombinant (His) | Human | HEK293 Cells |
gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa... | |||
TMPY-06039 | gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK) | Human | HEK293 Cells |
gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK) is expressed in HEK293 mammalian cells. The predicted molecular weight is 68.4 kDa and the accession number is P40189-1. | |||
TMPY-05793 | gp130/IL6ST Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
gp130/IL6ST Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 93.38 kDa and the accession number is Q00560. | |||
TMPY-01250 | IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.2 kDa and the accession number is Q64385. | |||
TMPY-03687 | gp130/IL6ST Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells |
gp130/IL6ST Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 102.6 kDa and the accession number is A0A8J8YAN3. | |||
TMPY-03743 | gp130/IL6ST Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells |
gp130/IL6ST Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.2 kDa and the accession number is A0A8J8YAN3. | |||
TMPY-02148 | gp130/IL6ST Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
gp130/IL6ST Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68.2 kDa and the accession number is H9BFG4. | |||
TMPY-01995 | gp130/IL6ST Protein, Rat, Recombinant (His & mFc) | Rat | HEK293 Cells |
gp130/IL6ST Protein, Rat, Recombinant (His & mFc) is expressed in HEK293 mammalian cells with His, mFc tag. The predicted molecular weight is 94.3 kDa and the accession number is H9BFG4. | |||
TMPH-03099 | Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc) | Sus scrofa (Pig) | E. coli |
Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.1 kDa and the accession number is P15145. | |||
TMPK-01114 | IL-31RA Protein, Human, Recombinant (aa 20-519, His) | Human | HEK293 Cells |
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f... | |||
TMPK-01096 | IL-31RA Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f... | |||
TMPK-01113 | IL-31RA Protein, Human, Recombinant (aa 20-519, hFc) | Human | HEK293 Cells |
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f... | |||
TMPJ-01467 | Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, ... | |||
TMPK-00289 | IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low af... | |||
TMPK-00089 | IL-11 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri... | |||
TMPK-00356 | IL-27RA/TCCR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-27Ra (also known as TCCR and WSX1) as a gene whose expression can induce the transformation of hematopoietic cells. IL-27Ra (IL-27R) is a type I cytokine receptor that functions as the ligand binding component of the ... | |||
TMPK-00088 | IL-11 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri... | |||
TMPJ-00086 | CT-1 Protein, Human, Recombinant (His) | Human | E. coli |
Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate and ovary, and to lower levels in lung, kidney, pancreas, t... | |||
TMPJ-00081 | CNTF Protein, Human, Recombinant | Human | E. coli |
Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species ... | |||
TMPJ-01199 | BTN2A1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two i... | |||
TMPY-02843 | GPX7 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants, and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to ... | |||
TMPJ-00047 | IL-31 Protein, Human, Recombinant | Human | E. coli |
Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes... | |||
TMPH-01503 | Humanin Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e... | |||
TMPH-01502 | Humanin Protein, Human, Recombinant (GST) | Human | E. coli |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e... |