expansion — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3635	IQ 1	IQ1,IQ-1	Wnt/beta-catenin
	IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on.		Wnt/beta-catenin
T2230	Paeoniflorin	Peoniflorin	HSP , COX
	Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.		HSP , COX
T15199	Edicotinib	JNJ-527,JNJ-40346527	c-Fms , FLT , CSF-1R , c-Kit
	Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the pote...		c-Fms , FLT , CSF-1R , c-Kit
T3590	NSC23005		CDK
	NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).		CDK
T6506	FPH1	BRD-6125	Others
	FPH1 (BRD-6125) (BRD-6125) can promote the expansion of iPS-derived hepatocytes.		Others
T24580	P18IN003	P18IN 003,P18IN-003	CDK
	P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of hematopoietic stem cells.		CDK
T3589	NSC23005 Sodium		CDK
	NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.		CDK
T24398	Lenaldekar	LDK	Akt , IGF-1R , S6 Kinase
	Lenaldekar (LDK) inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 kinase/AKT/mTOR pathway and delays sensitive cells in late mitosis.		Akt , IGF-1R , S6 Kinase
TQ0147	Arundic Acid	ONO 2506,(R)-2-Propyloctanoic acid	Others
	Arundic Acid (ONO 2506) is an astrocyte-modulating agent, delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis.		Others
T14973	CITCO		Apoptosis , Others
	CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors. CITCO is an imidazothiazole derivative and it al...		Apoptosis , Others
T77170	Siplizumab	MEDI-507	Others
	Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody targeting CD2. Siplizumab selectively depletes effector memory T cells and promotes relative expansion of alloreactive regulatory T cells in vitro. Siplizumab...		Others
T38861L	Tat-beclin 1 acetate	Tat-beclin 1 acetate(1423821-88-8 free base)	HIV Protease , Autophagy
	Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1. Tat-beclin 1 acetate decreases the accumulation of polyglutamine expansion protein aggregates and the ...		HIV Protease , Autophagy
T3S1471	Cucurbitacin IIA	Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis , Survivin
	1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ...		Apoptosis , Survivin
T32125	Hyperphyllin	HP
	Hyperphyllin specifically mimics the branch defects of AMP1, including plastid reduction and expansion and proliferation of the branch meristem.
T27279	ER819762	ER-819762,ER 819762
	ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion.
T71793	CDMG1
	CDMG1 is a novel Wnt inhibitor, promoting heart regeneration, injury repair, and myocardial hyperplasia through expansion of the cardiac progenitor cell population
T29166	XIE18-6	XIE186
	XIE18-6, a novel INK4C inhibitor, specifically blocks the bioactivity of p18 protein and promotes human and murine hematopoietic stem cell ex vivo expansion.
T39650	Tadnersen	IONIS-C9Rx,BIIB078
	Tadnersen (BIIB078) is an antisense oligonucleotide (ASO) designed for the selective targeting of C9ORF72 transcript variants 1 and 3, specifically those carrying the expansion.
T82642	Cyclo(RGDfK(Mal))
	Cyclo(RGDfK(Mal)), a pentapeptide, enhances the attachment and infiltration of human pluripotent stem cells and is utilized in three-dimensional stem cell culture and expansion [1].
T62859	MEIS-IN-1
	MEIS-IN-1 is a potent MEIS inhibitor that induces the expansion of hematopoietic stem cells in mice and humans.