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Cat No. | Product Name | Synonyms | Targets |
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T10919 | Cyclophilin inhibitor 1 | Others | |
Cyclophilin inhibitor 1 is an effective and orally bioavailable cyclophilin A inhibitor with a Kd of 5 nM, showing potent anti-HCV activity, and an EC50 for HCV 2a of 98 nM. | |||
T64220 | Cyclophilin inhibitor 3 | ||
Cyclophilin inhibitor 3 (compound 7c), a potent inhibitor of cyclophilin A (CypA), exhibited potent anti-HCV effects with an EC50 value of 4.2 μM. | |||
T5S1133 | Ganoderic acid D | Apoptosis , Sirtuin | |
1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 micr... | |||
T9936 | ZX-J-19J | N-(2,3-Diphenyl-6-quinoxalinyl)octanamide | Others |
ZX-J-19J (N-(2,3-Diphenyl-6-quinoxalinyl)octanamide), an inhibitor of Cyclophilin J (CyPJ), demonstrates remarkable inhibition of tumor cell growth, comparable to cyclosporine A but much stronger than 5-fluorouracil. | |||
T13171 | TMN355 | Others | |
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. | |||
T18928 | Brilliant Black BN | E 151 | Others , Virus Protease |
Brilliant Black BN (E 151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. | |||
T70811 | CRV431 | ||
CRV431 is a novel Pan-Cyclophilin Inhibitor, potently inhibiting all cyclophilin isoforms tested - A, B, D, and G (IC50 values ranged from 1-7 nM). | |||
T12226 | NIM811 | SDZ NIM811,(Melle-4)cyclosporin | Others |
NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin. | |||
T76228 | ASP5286 | ||
ASP5286 is a novel non-immunosuppressive cyclophilin inhibitor for the research of HCV . | |||
T14180 | Alisporivir | DEB-025,Debio-025 | Others |
Alisporivir (Debio-025) is a cyclophilin inhibitor molecule.It has potent anti-hepatitis C virus (HCV) activity. | |||
T71997 | CypD-IN-29 | ||
CypD-IN-29 is a non-peptidic inhibitor of cyclophilin D as a neuroprotective agent in Aβ-induced mitochondrial dysfunction. | |||
TP1387 | Cyclosporin A-Derivative 2 | ||
Derivative 2 is A novel Derivative of Cyclosporin A.Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin. | |||
TP1665 | Cyclosporin D | ||
Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells. | |||
T36642 | RAS/RAS-RAF-IN-1 | ||
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1]. RAS/RAS-RAF-IN-1 (compound 89; for ... | |||
T63090 | SMCypI C31 | ||
SMCypIC31 is a non-peptide cyclophilin inhibitor that effectively inhibits peptidyl-prolyl cis/trans isomerase (PPIase) (IC50: 0.1 μM). SMCypI C31 has a pan-genotypic effect against HCV, with an EC50 range of 1.20-7.76 μ... | |||
T74963 | CypD-IN-3 | ||
CypD-IN-3, a potent and subtype-selective cyclophilin D (CypD) inhibitor, exhibits a high affinity for CypD with an IC50 value of 0.01 μM. It is applicable in the research of various conditions, such as oxidative stress,... | |||
T74964 | CypD-IN-4 | ||
CypD-IN-4 is a potent, subtype-selective cyclophilin D (CypD) inhibitor exhibiting a high affinity for CypD with an IC50 value of 0.057 μM. This compound is utilized in the research of various diseases, such as oxidative... | |||
T74965 | CypE-IN-1 | ||
CypD-IN-1, a potent and subtype-selective inhibitor targeting cyclophilin E (CypE), demonstrates high affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. This compound is valuable for research into v... | |||
T75131 | RMC-6291 | ||
RMC-6291 is an orally active and covalent inhibitor of KRAS G12C (ON) . RMC-6291 forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRAS G12C (ON) from signali... |