cd18

Dexamethasone is a glucocorticoid receptor agonist and IL receptor modulator with anti-inflammatory, immunosuppressive, and apoptosis-inducing activities. It inhibits the production of inflammatory miRNA-155 exosomes in macrophages, significantly reduces inflammatory cytokine expression in neutrophils and monocytes, suppresses LPS-induced macrophage inflammation, and induces autophagy. It is commonly used to induce animal models of depression, muscle atrophy, and hypertension, and holds potential in COVID-19 research.

J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect. J-113863 is a potent and selective CCR1 (CD18) antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively.

Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.

Anti-Mouse CD18 Antibody (M18/2) is a rat-derived IgG2a, κ antibody inhibitor that targets mouse CD18.

Anti-CXCR4/CD184 Antibody is a CHO-expressed humanized antibody targeting CXCR4/CD184. It features a huIgG1 heavy chain and huλ light chain, with an estimated molecular weight (MW) of 145 kDa. For isotype controls, refer to HumanIgG1kappa, Isotype Control.

The compound, Anti-CXCR3/GPR9/CD183 Antibody, is a humanized antibody expressed in CHO, targeting CXCR3/GPR9/CD183. It features huIgG1 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 150 kDa. For isotype control, please refer to HumanIgG1kappa, Isotype Control.

The Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) is an IgG antibody inhibitor derived from a hamster originating from the United States, specifically targeting mouse CXCR3/CD183.

Anti-CD185/CXCR5 Antibody is an antibody inhibitor targeting human CD185/CXCR5.

Cyclosporin A is a natural product and an active fungal metabolite, classified as a cyclic polypeptide immunosuppressant. It binds to cyclophilin and inhibits the activity of calcineurin (IC₅₀ = 7 nM) as well as CD11a/CD18 adhesion molecules. It is commonly used to induce uremia models.

Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium-labeled form of Dexamethasone. Dexamethasone (Hexadecadrol) acts as an agonist of the glucocorticoid receptor and effectively reduces the expression of CD11b, CD18, and CD62L on neutrophils, as well as CD11b and CD18 on monocytes. It holds potential for research on COVID-19. In LPS-induced macrophage inflammatory responses, Dexamethasone inhibits the production of exosomes containing inflammatory miRNA-155.

Cyclosporin A-d4 is a deuterated form of Cyclosporin A. Cyclosporin A (Cyclosporine A) functions as an immunosuppressant by binding to cyclophilin and inhibiting calcineurin activity with an IC50 value of 7 nM. It also obstructs the adhesion molecules CD11a/CD18.

Cyclosporin Aacetate-d4 (Cyclosporine A acetate-d4; Ciclosporin A acetate-d4) is a deuterium-labeled form of Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressive agent that binds to cyclophilin, inhibiting the activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 value of 7 nM. Additionally, Cyclosporin A impedes the adhesion molecules CD11a/CD18.

Dexamethasone-4,6α,21,21-d4 is the deuterated derivative of Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) functions as an agonist of the glucocorticoid receptor. It notably reduces the expression of CD11b, CD18, and CD62L on neutrophils, as well as CD11b and CD18 on monocytes. Dexamethasone shows potential for research related to COVID-19.

Cyclosporin A-13C2,d4 (Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4) is a 13C-labeled form of Cyclosporin A. Cyclosporin A is an immunosuppressant that binds to cyclophilin, inhibiting protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 7 nM, and also suppresses the CD11a/CD18 adhesion molecules.

Cyclosporin A-d12 (Cyclosporine A-d12) is a deuterium-labeled form of Cyclosporin A. Cyclosporin A (Cyclosporine A) functions as an immunosuppressant by binding to cyclophilin and inhibiting protein phosphatase 2B (PP2B/calcineurin) with an IC50 value of 7 nM. It also inhibits the adhesion molecule CD11a/CD18.

Cyclosporin A (Standard) is a reference standard for research and analysis in studies involving Cyclosporin A. Cyclosporin A is a natural product and an active fungal metabolite, classified as a cyclic polypeptide immunosuppressant. It binds to cyclophilin and inhibits the activity of calcineurin (IC₅₀ = 7 nM) as well as CD11a/CD18 adhesion molecules. It is commonly used to induce uremia models.