erk2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11228	ERK2 IN-1		ERK
	ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.		ERK
T9034	MK2-IN-3	MK2 Inhibitor III	MAPK
	MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis		MAPK
T7005	Ulixertinib	BVD-523,VRT752271	ERK
	Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.		ERK
T10429	Tizaterkib	AZD-0364	ERK
	Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.		ERK
T11226	ERK1/2 inhibitor 1		ERK
	ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.		ERK
T1956	FR 180204	FR180204	Apoptosis , ERK
	FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.		Apoptosis , ERK
T6066	SCH772984		ERK , MEK
	SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases.		ERK , MEK
T5358	Longdaysin		ERK , Casein Kinase , CDK
	Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM).		ERK , Casein Kinase , CDK
T4092	AG126	Tyrphostin AG126,AG 126	ERK , COX
	AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expres...		ERK , COX
TP1970L	Prosaptide TX14(A) acetate	Prosaptide TX14(A) acetate(196391-82-9 free base)	ERK , GPR
	Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.		ERK , GPR
T6511	Ravoxertinib	GDC-0994	ERK
	Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).		ERK
T3074	CHIR 98024	CHIR98014	GSK-3 , S6 Kinase
	CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.		GSK-3 , S6 Kinase
T3001	Honokiol	NSC 293100	ERK , HCV Protease , MEK , Akt , Autophagy
	Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.		ERK , HCV Protease , MEK , Akt , Autophagy
T6324	(E/Z)-BIX02188	334949-59-6	ERK , MEK , TGF-beta/Smad
	BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, JNK2, and ERK2.		ERK , MEK , TGF-beta/Smad
T4091	Temuterkib	LY3214996	ERK
	Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity.		ERK
T3623	Cobimetinib	RG7420,XL518,GDC-0973	Apoptosis , MEK
	Cobimetinib (GDC-0973) is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of e...		Apoptosis , MEK
T6673	SKI II	SphK-I2	Apoptosis , Wnt/beta-catenin , S1P Receptor
	SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2.		Apoptosis , Wnt/beta-catenin , S1P Receptor
T3857	Magnolin	(+)-Magnolin	ERK
	Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.		ERK
T2310L	CHIR-99021 HCl	CT99021 HCl,Laduviglusib HCl	GSK-3
	CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivit...		GSK-3
T2608	CHIR-98014	CHIR 98014,CT98014,CHIR98014	FGFR , GSK-3 , Src , S6 Kinase
	CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.		FGFR , GSK-3 , Src , S6 Kinase