Chitin

Chitin is a large, structural polysaccharide found in the cell walls of fungi, the exoskeletons of insects, and certain hard structures in fish and invertebrates.

Chlorobenzuron, a chitin synthetase inhibitor, functions as an insecticide by inhibiting larval development and pupation.

Nikkomycin Z (Nikkomycin Z from Streptomyces tendae) is a competitive chitin synthase inhibitor.It inhibitor of the growth of filamentous fungi, insects, acarids and yeasts.

Chitin synthase-IN-15 (Compound 6k) is an inhibitor of chitin synthase and exhibits insecticidal activity against the diamondback moth (Plutella xylostella) with LC50 values of 0.789 and 0.951 μg/mL. It effectively disrupts molting, causes larval death, and leads to abnormal pupation, resulting in a significant reduction in pest populations. Chitin synthase-IN-15 is considered an insecticide with favorable ecological safety.

Chitin synthase inhibitor 2 (compound 2b) is a highly potent inhibitor of chitin synthase, with an IC50 of 0.09 mM and a K i of 0.12 mM. This compound exhibits antimicrobial activity in vitro and demonstrates synergistic or additive effects when combined with fluconazole or polyoxin B [1].

Chitin Synthase Inhibitor 3 (Compound 2d) is a potent inhibitor of chitin synthase, exhibiting an IC50 value of 0.16 mM and demonstrating antifungal activity with a minimum inhibitory concentration (MIC) of 1 μg/mL against Candida albicans [1].

Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor with an IC50 of 0.12 mM, effectively inhibiting drug-resistant fungi variants.

Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal properties, suitable for research on fungal infections.

Chitin synthase inhibitor 7 (compound 9c), a potent inhibitor of chitin synthase (CHS) with an IC50 of 0.37 nM, can be used to study fungal infections.

Chitin synthase inhibitor 6 (compound 9b) is a potent inhibitor of chitin synthase (CHS) with an IC50 of 0.21 mM, exhibiting broad-spectrum antifungal effects against drug-resistant fungi, and is useful for studying fungal infections.

Chitin synthase inhibitor 9, a chitin synthase (CHS) inhibitor, exhibits broad-spectrum antifungal activity and is useful for studies of fungal infections.

Chitin synthase inhibitor 12, a Chitin synthase (CHS) inhibitor, showed excellent CHS inhibition (IC50: 0.16 mM). Chitin synthase inhibitor 12 is also a broad-spectrum antifungal agent resistant to resistant fungal variants (e.g. C. albicans, C. neoformans). Chitin synthase inhibitor 12 can be used to study invasive fungal infections (IFIs).

Chitin synthase inhibitor 11 is a powerful chitin synthase (CHS) inhibitor that markedly reduces CHS activity (IC50: 0.10 mM) and exhibits broad-spectrum in vitro antifungal activity.

Chitin synthase inhibitor 5 effectively blocks chitin synthase, a key enzyme in fungal cell wall formation, with a low IC50 value of 0.14 mM. Chitin synthase inhibitor 5 demonstrates broad-spectrum antifungal activity against Candida albicans, Aspergillus species, and Cryptococcus neoformans.

Chitin Synthase Inhibitor 10, as a potent chitin synthase inhibitor, exhibits remarkable inhibitory activity with an IC50 of 0.11 mM. It also functions as an antifungal agent, demonstrating substantial effectiveness against drug-resistant fungi, including C. albicans and C. neoformans. The compound is useful in researching invasive fungal infections (IFIs) [1].

Chitin Synthase Inhibitor 14 (compound 4n), a potent chitin synthase (CHS) inhibitor, exhibits antifungal activity and is effective against drug-resistant fungal strains [1].

Chitin Synthase Inhibitor 13 (compound 12g), a non-competitive antagonist of chitin synthase, demonstrates broad-spectrum antifungal activity and has an inhibition concentration (IC50) of 106.7 μM [1].

Chitin synthase inhibitor 4 is a chitin synthase (CHS) inhibitor with antimicrobial activity.Chitin synthase inhibitor 4 is a CHS-based compound and a candidate fungicide.

Chitin, from shrimp shells (powder), is a biochemical reagent that serves as a biomaterial or organic compound for research in the life sciences.

Buprofezin (Applaud) is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops.

Diflubenzuron (Larvakil) is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2 cells.

Chitosan (MW 150000) (Deacetylated chitin) is a linear polysaccharide made up of randomly distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine.

Etoxazole is an acaricide/insecticide that works via chitin biosynthesis inhibition for the control of mites. Used as a standard for Pesticide detection.

Hexaflumuron is a chitin synthesis inhibitor used to bait and eliminate termite colonies. Termites are unable to metabolize hexaflumuron and clearance is slow, resulting in up to 100% elimination. Hexaflumuron has also been tested for use with the raisin