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Etoxazole

Name: Etoxazole
Brand: TargetMol
SKU: T4055
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4055Cas No. 153233-91-1

Etoxazole is an acaricide/insecticide that works via chitin biosynthesis inhibition for the control of mites. Used as a standard for Pesticide detection.

Etoxazole

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Purity: 99.94%

Catalog No. T4055Cas No. 153233-91-1

Etoxazole is an acaricide/insecticide that works via chitin biosynthesis inhibition for the control of mites. Used as a standard for Pesticide detection.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$37	In Stock	In Stock
25 mg	$57	In Stock	In Stock
50 mg	$107	In Stock	In Stock
100 mg	$165	In Stock	In Stock
500 mg	$416	-	In Stock
1 mL x 10 mM (in DMSO)	$41	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Etoxazole AI Summary

Etoxazole demonstrates a multifaceted profile of bioactivities across various biological systems and organisms. It functions as both an agonist and antagonist for multiple signaling pathways, including estrogen receptor alpha, peroxisome proliferator-activated receptor gamma, farnesoid X receptor, antioxidant response element, rat and human pregnane X receptor, and androgen receptor signaling pathways. In terms of pesticidal activity, Etoxazole exhibits potent insecticidal properties against several pests, achieving 100% mortality at 500 ppm for Myzus persicae (green peach aphid), Plutella xylostella (diamondback moth), and Nephotettix cincticeps (green rice leafhopper). It shows strong acaricidal activity against Tetranychus urticae (two-spotted spider mite) with an LC50 value of 0.001 ppm for larvicidal activity and causes mortality in eggs with an LC50 of 13.8 nM on compound-treated kidney bean leaves. Additionally, it demonstrates efficacy against Panonychus ulmi larvae with LC50 values of 0.15 ug/mL and greater than 10000.0 ug/mL for different strains, indicating a notable insecticidal potency particularly against resistant strains. Additional experiments highlight its impact on bumblebee workers (Bombus terrestris), with a NOAEL of 0.55 mgAi/L and LC50 of 4.4 mgAi/L when administered through sugar water over 11 weeks. A striking reduction in reproductive activity and high mortality rates are observed at concentrations of 55 mg a.i./l when delivered via pollen (25% reproductive reduction) and sugar water (95% mortality), respectively. However, topical application at the same concentration results in less than 25% mortality over the same period. Moreover, Etoxazole exhibits activity against spirodiclofen-resistant and susceptible Tetranychus urticae larvae, with LC50 values of 0.61 ug/mL for resistant and 0.76 ug/mL for susceptible larvae, suggesting slight variability in efficacy between resistant and susceptible strains. Overall, Etoxazole is characterized by its versatile bioactivity and marked efficacy in pest control applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Etoxazole is an acaricide/insecticide that works via chitin biosynthesis inhibition for the control of mites. Used as a standard for Pesticide detection.

Chemical Properties

Molecular Weight	359.41
Formula	C₂₁H₂₃F₂NO₂
Cas No.	153233-91-1
Smiles	CCOc1cc(ccc1C1COC(=N1)c1c(F)cccc1F)C(C)(C)C
Relative Density.	1.15g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (139.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.67 mg/mL (4.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7823 mL	13.9117 mL	27.8234 mL	139.1169 mL
5 mM	0.5565 mL	2.7823 mL	5.5647 mL	27.8234 mL
10 mM	0.2782 mL	1.3912 mL	2.7823 mL	13.9117 mL
20 mM	0.1391 mL	0.6956 mL	1.3912 mL	6.9558 mL
50 mM	0.0556 mL	0.2782 mL	0.5565 mL	2.7823 mL
100 mM	0.0278 mL	0.1391 mL	0.2782 mL	1.3912 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc