cd40 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T17157	TRAF-STOP inhibitor 6877002	CD40-TRAF6 inhibitor	NF-κB
	TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor), is a selective inhibitor of CD40-TRAF6 interaction. TRAF-STOP 6877002 reduces leukocyte recruitment, and reduces macrophage activation; reduces macrophage proliferation...		NF-κB
T76830	Teneliximab	Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819	TNF
	Teneliximab (Chi220) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts partial agonist activity through CD...		TNF
T78312	Cifurtilimab	SEA-CD40
	Cifurtilimab (SEA-CD40), a nonfucosylated humanized IgG1 monoclonal antibody with agonistic properties, targets the CD40 receptor and demonstrates antitumor activities [1] [2].
T82858	Bleselumab	ASKP 1240,Anti-Human CD40 Recombinant Antibody
	Bleselumab (ASKP 1240), a human anti-CD40 monoclonal antibody (mAb), exhibits high-affinity binding to CD40 (Kd: 0.24 nM) and hinders immune responses by impeding the CD40-CD40L interaction, thereby preventing organ tran...
T9926	Omalizumab		Others
	Omalizumab is a recombinant humanized monoclonal antibody against human immunoglobulin E IgE)		Others
T0948L	Corticosterone	17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants)	Glucocorticoid Receptor , Endogenous Metabolite
	Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stres...		Glucocorticoid Receptor , Endogenous Metabolite
T11096	DRI-C21045		NF-κB
	Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.Dri-c21045 is an effective selective inhibitor of CD40-CD40L...		NF-κB
T79194	DRI-C25441
	DRI-C25441 is a potent inhibitor of the CD40-CD40L interaction, exhibiting an IC50 value of 0.36 μM, and is capable of suppressing the immune response triggered by alloantigen [1].
T77035	Inezetamab
	Inezetamab is a bispecific anti- CD40 and anti- MSLN IgG1 monoclonal antibody [1] .
T82615	Dalnicastobart	LVGN-7409
	Dalnicastobart (LVGN-7409) is a human IgG1κ monoclonal antibody that specifically targets CD40, also known as TNFRSF5 [1].
T73865	(Rac)-BIO8898
	(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154. It effectively prevents CD154 from binding to CD40-Ig, demonstrating an inhibitory concentration ...
T73866	BIO8898
	BIO8898, a potent inhibitor of the CD40-CD154 interaction, effectively prevents soluble CD40L from binding to CD40-Ig, demonstrating an inhibitory concentration (IC 50) value of 25 µM. Additionally, BIO8898 suppresses CD...
T76729	Lucatumumab
	Lucatumumab (HCD122), a fully human anti-CD40 antagonist monoclonal antibody, effectively inhibits CD40/CD40L-mediated signaling and promotes antibody-dependent cell-mediated cytotoxicity (ADCC) for tumor cell clearance....
T24808	SMI-6860766	TRAFSTOP 6860766,TRAF-STOP 6860766,SMI 6860766,TRAFSTOP6860766,SMI6860766
	SMI-6860766 is a CD40-Traf6 interactions blocker that acts by ameliorating the complications of diet-induced obesity in mice.
T70214	BMS-986202
	BMS-986202 is a novel Tyk2 inhibitor, binding to Tyk2 JH2, showing efficacies for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus.
T61810	Anti-inflammatory agent 16
	Anti-inflammatory agent 16 (compound 14) is a highly effective peptidomimetic with potent anti-inflammatory properties. It effectively reduces the expression levels of TNFα, NO, CD40, and CD86 [1].
T78251	Sotigalimab
	Sotigalimab, a CD40 agonistic monoclonal antibody, is utilized in research targeting metastatic pancreatic adenocarcinoma [1].
T78250	Selicrelumab
	Selicrelumab, an agonist CD40 antibody, modifies the tumor microenvironment and is utilized in pancreatic cancer research and neoadjuvant studies [1].
T77143	Ravagalimab
	Ravagalimab (ABBV-323), a CD40 antagonist with an EC50 of 3.7 nM, is utilized in the research of Crohn's disease [1].
T77013	Frexalimab
	Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1].