bace-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3161L	BACE-IN-1 acetate	BACE-IN-1 acetate (350228-37-4，Free base)	BACE
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precursor protein (APP) c...		BACE
T10449	BACE-1 inhibitor 1		Others
	BACE-1 inhibitor 1 (Compound 8a) is an effective BACE-1 inhibitor (IC50: 56 nM).		Others
T11175	Elenbecestat	E2609	Beta-Secretase , BACE
	Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.		Beta-Secretase , BACE
T62181	BACE-IN-1
	BACE-IN-1 is an imidazo[1,2-a]pyridine derivative that inhibits the β-site amyloid precursor protein cleavage enzyme (BACE) sentence.BACE-IN-1 has the potential to investigate diseases involving BACE, such as Alzheimer's...
T62995	BACE-1 inhibitor 2
	BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].
T61206	AChE/BChE/BACE-1-IN-1
	AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It displays IC50 ...
T60691	AChE/BChE/BACE-1-IN-2
	AChE/BChE/BACE-1-IN-2 (Compound 4o) exhibits remarkable antioxidant potential and considerable binding capability towards PAS-AChE. AChE/BChE/BACE-1-IN-2 is an orally active AChE, BACE-1 and BChE inhibitor with IC 50 val...
T10450	BACE1-IN-1		BACE
	BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).		BACE
T10451	BACE1-IN-2		BACE
	BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).		BACE
T10453	BACE1-IN-5		Beta Amyloid , BACE
	BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM aga...		Beta Amyloid , BACE
T10452	BACE1-IN-4		BACE
	BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.		BACE
T3161	β-Secretase inhibitor-STA		Beta-Secretase
	BACE-IN-1 is amyloid precursor protein beta-secretase inhibitor		Beta-Secretase
T39484	BACE1-IN-6	BACE1-IN-6
	BACE1-IN-6 is a BACE1 inhibitor with an IC 50 value of 1.5 nM.
T13253	Umibecestat	CNP520	BACE
	Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of al...		BACE
T83616	SEW06622		BACE , AChE
	SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease.		BACE , AChE
T6058	LY2886721		Beta-Secretase , BACE
	LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.		Beta-Secretase , BACE
T2S1181	Aloenin	Aloenin A,Aloearbonaside	Beta-Secretase , AChR
	1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.		Beta-Secretase , AChR
T13434	β-Secretase Inhibitor IV		Others
	β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).		Others
T71383	NB-533
	NB-533 is a macrocyclic peptidic BACE-1 inhibitor.
T68278	NB-216
	NB-216 is a macrocyclic peptidic BACE-1 inhibitor.