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Results for "

α7 nachr

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    62
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    5
    TargetMol | Peptide_Products
  • Natural Products
    1
    TargetMol | Natural_Products
JNJ-39393406
T27679953428-73-4In house
JNJ-39393406 is an α7 nicotinic acetylcholine receptor positive allosteric modulator for the study of tobacco dependence and Alzheimer's disease.
  • $62
In Stock
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CP-810123
UNII-E6G4550EC4, CP810123, CP 810123
T31079439608-12-5In house
CP-810123 is a new alpha 7 nAChR agonist for the treatment of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease.
  • $293 TargetMol
In Stock
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QTY
SSR 180
T84293298198-52-4In house
SSR 180 is a potent and subtype-selective α7 agonist with applications in the study of Alzheimer;s disease and schizophrenia.
  • $195 TargetMol
In Stock
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QTY
Methyllycaconitine citrate
MLA
T12017351344-10-0
Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.
  • $49
In Stock
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gts-21
GTS21, GTS 21, DMXB-A
T19933148372-04-7
GTS-21 (DMXB-A) is an α7 nAChR agonist. GTS-21 suppresses inflammation associated with rheumatoid arthritis by inhibiting RA Th1 cell differentiation.
  • $1,520
1-2 weeks
Size
QTY
α7 nAchR-JAK2-STAT3 agonist 1
T623172108714-20-9
α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). It has demonstrated positive effects on iNOS, IL-1β, and IL-1β in murine macrophages RAW264.7, and inhibited the expression of iNOS, IL-1β, and IL-6 in mouse macrophages. Additionally, α7 nAchR-JAK2-STAT3 agonist 1 suppressed LPS-induced NO release, NF-κB activation, and cytokine production, making it useful for studying sepsis.
  • $2,140
6-8 weeks
Size
QTY
PHA 543613
T23145478149-53-0In house
PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
  • $46
In Stock
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GAT107
GAT 107, GAT-107
T274041476807-74-5In house
GAT107 is a novel and potent α7 nicotinic cholinergic receptor modifier agonist and modulator with anti-inflammatory activity that reverses injury perception in a mouse model of neuropathic pain.
  • $155
In Stock
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SSR180711 hydrochloride
SSR-180711A HCl, SSR-180711C HCl, SR-180711 HCl
T28856446031-79-4In house
SSR180711 hydrochloride (SSR-180711A HCl) is a selective Alpha7 nicotinic acetylcholine partial agonist for the study of neurodegenerative and cognitive disorders.
  • $30
In Stock
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TC-2216
T68154646055-67-6In house
TC-2216 is a partial agonist at the neural nicotinic acetylcholine receptor and is used to treat anxiety and depression.
  • $36
In Stock
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QTY
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Cynandione A
T70277168706-29-4In house
Cynandione A, an acetophenone derived from Cynanchum wilfordii, has anti-inflammatory activity and significantly reduces pro-inflammatory cytokine overexpression via macrophage α7 nAChR activation and subsequent IL-10 expression.
  • $518 TargetMol
In Stock
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Benzethonium chloride
Hyamine, Phemeride, Quatrachlor
T0401121-54-0
Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
  • $36
In Stock
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PNU-282987
T2422123464-89-1
PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
  • $41
In Stock
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PHA 568487 free base
PHA 568487
T23146527680-56-4
The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.
  • $37
In Stock
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S 24795
Catestatin acetate(142211-96-9 free base), LNAChR
T23286304679-75-2
S 24795 (Catestatin acetate(142211-96-9 free base)) is an α7 nAChR partial agonist. S 24795 improves mnemonic function in aged mice and can be used in studies about aging-related memory disturbances.
  • $39
In Stock
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TQS
4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
T23469353483-92-8
TQS (4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) is a positive allosteric modulator of α7 nACh receptors.
  • $32
In Stock
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PNU-282987 S enantiomer free base
T7695737727-12-7
PNU-282987 S enantiomer free base is an agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR).
  • $68
In Stock
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A 582941 HCl (848591-90-2(free base))
T8725
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
  • $56
In Stock
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4BP-TQS
T8868360791-49-7
4BP-TQS is an allosteric agonist of α7 nAChRs.
  • $41
In Stock
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nAChR agonist 1
DUN71755
T121651394371-75-5
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.
  • $86
In Stock
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Rivanicline hemioxalate
RJR-2403 hemioxalate, (E)-Metanicotine hemioxalate
T12738
Rivanicline hemioxalate, also known as RJR-2403 hemioxalate or (E)-Metanicotine hemioxalate, is a chemical compound acting as a neuronal nicotinic receptor agonist with pronounced selectivity for the α4β2 receptor subtype, showing over 1,000-fold greater selectivity for this subtype (Ki=26 nM) compared to α7 receptors (Ki=3.6 μM). Its in vitro studies demonstrate no significant activation of nAChRs in PC12 cells, muscle type nAChRs, or muscarinic receptors at concentrations up to 1 mM. Furthermore, Rivanicline displayed less than one-tenth the potency of nicotine in inducing ileum contraction, with substantially lower efficacy, and failed to antagonize nicotine-induced stimulation of muscle or ganglionic nAChR functions, with an IC50 value greater than 1 mM. Chronic exposure to Rivanicline at 10 microM led to up-regulation of high-affinity nAChRs in M10 cells, mimicking effects observed with nicotine. In vivo studies revealed that Rivanicline significantly reversed scopolamine-induced amnesia and improved working and reference memory in a rat model, while being 15 to 30 times less potent than nicotine in affecting body temperature, respiration, and other physiological responses. Metanicitone's potency was approximately five times lower than nicotine in tail-flick tests following subcutaneous administration, yet slightly more potent upon central administration.
  • $1,774
1-2 weeks
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Asoxime dichloride
Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate, HI-6, Asoxime (dichloride)
T1433334433-31-3
Asoxime dichloride (Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system. Asoxime dichloride involves in modulating immunity response.
  • $78
In Stock
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Pozanicline hydrochloride
T16563L
Pozanicline hydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline hydrochloride is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant[2].
  • $70
In Stock
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(-)-(S)-B-973B
T173002244989-34-0
(-)-(S)-B-973B is an effective allosteric agonist and positive allosteric modulator of α7 nAChR.
  • $45
In Stock
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