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ABCA1 inducer 3
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Catalog No. T218198 Copy Product Info
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ABCA1 inducer 3 (Compound 85) is an orally active ABCA1 inducer and lipid regulator. It enhances ABCA1 expression levels and upregulates mRNA expression of Abcg5 and Abcg8 in the liver. Additionally, ABCA1 inducer 3 promotes cholesterol efflux and ameliorates hyperlipidemia.
ABCA1 inducer 3
Cas No. 2681270-30-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ABCA1 inducer 3 (Compound 85) is an orally active ABCA1 inducer and lipid regulator. It enhances ABCA1 expression levels and upregulates mRNA expression of Abcg5 and Abcg8 in the liver. Additionally, ABCA1 inducer 3 promotes cholesterol efflux and ameliorates hyperlipidemia. |
| In vitro | ABCA1 inducer 3 (10 μM; 24 h) significantly upregulates ABCA1 in ABCA1p-LUC HepG2 cells by 578%, with an EC50 of 0.15 μM. In RAW264.7 macrophages, ABCA1 inducer 3 (2.5-10 μM; 24 h) moderately and dose-dependently increases Abca1 mRNA expression. Additionally, ABCA1 inducer 3 (10 μM; 18 h) enhances cholesterol efflux from RAW264.7 macrophages. |
| In vivo | Administering ABCA1 inducer 3 at a dosage of 50 mg per day orally for 8 weeks offers protective effects against hyperlipidemia in golden hamsters. |
| Molecular Weight | 551.26 |
| Formula | C18H14BrCl2N3O4S2 |
| Cas No. | 2681270-30-2 |
| Smiles | O=C(O)C=1C=C(Br)C=2N=C(SC2C1)N3CCN(CC3)S(=O)(=O)C=4C=CC=C(Cl)C4Cl |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Related Tags: ABCA1 inducer 3 in vivo | ABCA1 inducer 3 in vitro | ABCA1 inducer 3 formula | ABCA1 inducer 3 molecular weight
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