y-11

focal adhesion kinase (FAK) inhibitor

1b-Hydroxy-11a,13-dihydroalantolactone is a useful organic compound for research related to life sciences. The catalog number is T125418 and the CAS number is 200703-30-6.

KWZY-11 (Compound 11) is a potent dual inhibitor of PARP/CDK6, exhibiting IC50 values of 156.8 nM, 197.3 nM, and 13.3 nM for PARP1, PARP2, and CDK6 respectively. It suppresses tumor cell proliferation by modulating the Wnt/β-catenin signaling pathway. Additionally, KWZY-11 induces excessive DNA damage and apoptosis in MDA-MB-231 breast cancer cells.

(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoid, demonstrates significant inhibitory effects on nitric oxide (NO) production in BV-2 microglia cells induced by n LPS, with an IC50 value of 9.55 uM. Additionally, this compound possesses anti-inflammatory properties.

WAY-118959-A (GM-90257) is a competitive inhibitor of αTAT1 (α-tubulin acetyltransferase 1) that directly binds to α-tubulin and inhibits microtubule acetylation, attenuates tumor growth in vivo and induces apoptosis of MDA-MB-231.

9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential applications in anticancer research [1].

WAY-119918 is an active molecule with the chemical formula C21H23NO3, a molecular weight of 337.41 g/mol, and appears as an off-white powder. It demonstrates significant activity in assays targeting the central nervous system (CNS) receptors, particularly in models assessing antidepressant and anxiolytic effects. [PubChem 12345].

10,13-epoxy-11-methyl-Octadecadienoic Acid is an active molecule that can be used in life science related research. The CAS number of 10,13-epoxy-11-methyl-Octadecadienoic Acid is 57818-39-0.

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg/rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb/db mouse model of type 2 diabetes.

11-Deoxy-11-methylene PGD2 (11d-11m-PGD2), an isosteric analogue of Prostaglandin 2, features a chemically stable structure where the 11-keto group is substituted with an exocyclic methylene. This compound notably enhances fat storage, an effect that is diminished in the presence of Indomethacin [1].

14-Deoxy-11,12-didehydroandrographolide (Standard) is a reference standard for research and analysis in studies involving 14-Deoxy-11,12-didehydroandrographolide. 14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.

23S-hydroxy-11,15-dioxo-ganoderic acid DM is a natural product

3beta,7beta,15beta-trihydroxy-11-oxo-lanosta-8-en-24->20 lactone is a natural product

14-Deoxy-11-oxoandrographolide is a natural product from Andrographis paniculata

14-Deoxy-11,12-didehydroandrographiside, a natural product from Andrographis (Acanthaceae), is cataloged as TN2622 and has the CAS number 141973-41-3. It can be used as a reference standard.

3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.

3β-Hydroxy-urs-11-en-28,13β-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. It exhibits weak-moderate antiproliferative activity ag

4-Hydroxy-11,12,13-trinor-5-eudesmen-7-one is a natural product for research related to life sciences. The catalog number is TN3032 and the CAS number is 133369-42-3.

14-Deoxy-11-hydroxyandrographolide shows potent cell differentiation-inducing activity towards mouse myeloid leukemia (M1) cells.

ent-15α-Acetoxy-11α-hydroxykaur-16-en-19-oic acid is a natural product for research related to life sciences. The catalog number is TN5621 and the CAS number is 70324-38-8.

3β-Acetoxy-11α,12α-epoxyoleanan-28,13β-olide is a natural product. The catalog number is TN5958 and the CAS number is 35738-25-1. 3β-Acetoxy-11α,12α-epoxyoleanan-28,13β-olide can be used as a reference standard.

3-Deoxy-11,13-dihydroisosecotanapartholide is a natural product for research related to life sciences. The catalog number is TN6365 and the CAS number is 572924-43-7.

1β,4β-Dihydroxy-11,12,13-trinoreudesm-5-en-7-one is a sesquiterpene compound.

3β,7β-Dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic is a triterpenoid compound identified in Ganoderma lucidum.