vh032

VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a ligand of VHL.

VH032 thiol (VHL ligand 6) is a VHL ligand that connects via a linker to the pan-BET inhibitor JQ1 to form a PROTAC[1] compound.

(S,S,S)-VH032 is a ligand for the E3 ligase (VHL) and is used in the synthesis of PROTACSGK3degrader-2.

(R,S,S)-VH032 is a ligand for E3 ligase and a VHL/HIF-1α interaction inhibitor utilized in the synthesis of PROTACs, particularly the tau-targeting small molecule PROTAC C004019 [1]. As a VHL ligand, it recruits von Hippel-Lindau (VHL) proteins, facilitating the development of targeted protein degradation therapies.

(S,R,R)-VH032 (Compound V3) is a VHL ligand utilized in the synthesis of PROTACNCOA4 degrader-1.

VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule that includes the VH032-based VHL ligand and a 5-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

VH032-thiol-C6-NH2, also known as VHL Ligand-Linker Conjugates 14, is a synthesized compound that functions as an E3 ligase ligand-linker conjugate. This compound combines the VH032 based VHL ligand with a linker commonly utilized in PROTAC technology.

trans-VH032-Cyclopropane-F-C-cyclohexane-p-C-OTs contains a VHL ligand for recruiting E3 ubiquitin ligase and a PROTAC linker. VHL Ligand-Linker Conjugates 15 is applicable for the synthesis of PROTACs, such as dBAZ2B.

(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), composed of N-Boc-7-aminoheptanoic acid and the corresponding linker. It is utilized in the synthesis of dTAGV-1-NEG.

(R,S,S)-VH032-Me is a ligand for the E3 ubiquitin ligase. It can connect with a target protein ligand via a linker to form dTAGV-1-NEG. This PROTAC can induce the ubiquitination and subsequent degradation of oncogenic proteins.

RB-CO-PEG5-C2-CO-VH032 is a TRIM24 degrader that can inactivate the mTOR signaling pathway.

(R,S,S)-VH032-Me-glycine is an E3 ubiquitin ligase ligand-linker conjugate, which can be utilized in the synthesis of XF067-68.

VH032-cyclopropane-F-C4-CHO is an E3 ubiquitinase ligand-linker conjugate, which can be utilized in the synthesis of LC-MF-4.

(R,S,S)-VH032-Me TFA is an E3 ligase ligand utilized in the synthesis of [dTAGV-1 hydrochloride].

(S,S,S)-VH032-cyclopropane-F-C4-aldehyde is a conjugate of an E3 ligase ligand-linker. It is utilized in the synthesis of PROTACcis-VZ185.

(S,S,S)-VH032-cyclopropane-F is an E3 ubiquitin ligase ligand. It can be linked to a target protein ligand using a linker to form PROTACcis-VZ185.

(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA is a conjugate that consists of an E3 ubiquitin ligase ligand and a linker. This compound is useful for synthesizing dTAGV-1 hydrochloride.

NASA-linker-VH032-PEG3 ligand is a ligand used in the synthesis of PROTACs.

(R,S,S)-VH032-PEG5-N3 is a conjugate combining an E3 ligase ligand-linker structure, featuring a VH032-based VHL ligand along with a 5-unit PEG linker. This compound acts as a click chemistry reagent and includes an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with molecules that have DBCO or BCN groups.

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand with terminal hydroxyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).

(S,R,S)-AHPC (VH032-NH2) is a VH032-based ligand for recruiting the von Hippel-Lindau (VHL) protein, potentially useful for the targeted degradation of the androgen receptor.

(S,R,S)-AHPC-propargyl, a VHL ligand, is utilized in click reactions for PROTACs.

(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) is a VHL amino building block and ligand used as a negative control for (S,R,S)-AHPC. It is based on VH032 and is employed in the recruitment of the VHL protein.