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SPHINX is a new generation inhibitor of SPRK1

TCS PIM-1 1 (SC 204330)(sc-204330) is an effective and specific ATP-competitive Pim-1 kinase inhibitor (IC50: 50 nM), exhibiting good specificity over MEK1/MEK2 and Pim-2 (IC50s > 20,000 nM).

Azulene (Bicyclo[5.3.0]Decapentaene) is a natural product.

Caveolin-1 (82-101) amide (human, mouse, rat), also known as Caveolin-1 scaffolding domain peptide, mitigates aging-related detrimental alterations in various organs and inhibits tyrosine kinases [1].

Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion while reducing pro-inflammatory cytokine secretion (e.g., IL-6, IL-8). It offers low toxicity and high affinity, making it suitable for metastatic cervical, gastric, hepatic, and pulmonary cancers, pancreatic cancer, and oesophageal squamous cell carcinoma.

BMS-1166-n-piperidine-co-n-piperazine dihydrochloride, a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitor, inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It contains the target protein PD-1/PD-L1 ligand and PROTAC linker, which can be used to synthesize PROTAC PD-1/PD-L1 degrader-1 and has anticancer activity. Additionally, it serves as a diluent for the preparation of tablets for direct compression.

7-Azaindole-4-carboxylic acid ,with CAS No. 479553-01-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-Azaindole-4-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-Benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ,with CAS No. 189089-90-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid ,with CAS No. 1067193-34-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

6-Chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ,with CAS No. 800402-07-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER, ,with CAS No. 159749-28-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Tert-butyl cis-3-hydroxymethylcyclobutylcarbamate ,with CAS No. 142733-64-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Tert-butyl cis-3-hydroxymethylcyclobutylcarbamate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-(4-Bromophenyl)cyclopropanecarboxylic acid ,with CAS No. 345965-52-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(4-Bromophenyl)cyclopropanecarboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(1R,5S,6R)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid ,with CAS No. 927679-54-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (1R,5S,6R)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(S)-tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide ,with CAS No. 396074-50-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (S)-tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Amino-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid ethyl ester ,with CAS No. 117642-16-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Amino-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid ethyl ester provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

7-Amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester ,with CAS No. 171049-41-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-Amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2,2-Dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one ,with CAS No. 20348-21-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2,2-Dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

6-Bromo-1,4-dihydro-2H-3,1-benzoxazin-2-one ,with CAS No. 1017783-09-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Bromo-1,4-dihydro-2H-3,1-benzoxazin-2-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Amino-4,7-dihydro-5H-thieno[2,3-c]pyridine-3,6-dicarboxylic acid 6-tert butyl ester 3-ethyl ester ,with CAS No. 193537-14-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Amino-4,7-dihydro-5H-thieno[2,3-c]pyridine-3,6-dicarboxylic acid 6-tert butyl ester 3-ethyl ester provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Methylphenylsulfonylurea ,with CAS No. 1694-06-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Methylphenylsulfonylurea provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Tert-butyl 4-(1-hydroxycyclopropanecarbonyl)piperazine-1-carboxylate ,with CAS No. 1788054-84-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Tert-butyl 4-(1-hydroxycyclopropanecarbonyl)piperazine-1-carboxylate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-Boc-2-methylpiperazine ,with CAS No. 120737-78-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Boc-2-methylpiperazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(R)-1-Boc-3-(hydroxymethyl)piperazine ,with CAS No. 278788-66-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (R)-1-Boc-3-(hydroxymethyl)piperazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.