Search Result

Search Results for " plasticity "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T16745	Rhosin hydrochloride		Apoptosis , Rho , Ras
	Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o...		Apoptosis , Rho , Ras
T2161	Cardiogenol C		Wnt/beta-catenin
	Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.		Wnt/beta-catenin
T8005	Cardiogenol C hydrochloride	Cardiogenol C HCl,Cardiogenol C	Wnt/beta-catenin
	Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).		Wnt/beta-catenin
T7516	ZD7288	ICI D7288	HCN Channel
	ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.		HCN Channel
T3597	Cutamesine dihydrochloride	AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride	Sigma receptor
	Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr...		Sigma receptor
T70064	PDE1-IN-1
	PDE1-IN-1can enhance levels of the second messengers cAMP/cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and neuroprotective molecules. These neuronal plasticity enhancement pr...
T62055	NVS-BET-1
	NVS-BET-1 is a BET bromodomain inhibitor. NVS-BET-1 can regulate keratinocyte plasticity.
T70032	NCI-006
	NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both m...
T76078	Neurogranin (48-76), mouse
	Neurogranin (48-76), mouse, is a peptide comprising residues 48-76 of Neurogranin, a post-synaptically exclusive calmodulin-binding protein that mediates NMDAR-driven synaptic plasticity by regulating the calcium-calmodu...
T37388	Afizagabar
	Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal sy...
T82673	CPF-7	Caerulein precursor fragment
	CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulation in PANC-1 ductal cells. Moreover, it induces exocrine plasti...
T62127	AMPA-IN-1
	AMPA-IN-1 is a potent inhibitor of AMPA receptors, a widely expressed receptor in the brain with a central role in the regulation of rapid excitatory synaptic transmission and synaptic plasticity. 14).
TP2157L	TAT-DEF-Elk-1 TFA (1220751-16-5 free base)	TDE TFA,TAT-DEF-Elk-1 TFA	Others
	TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation withou...		Others
T76221	Leptin (116-130)
	Leptin (116-130), a bioactive fragment of leptin, enhances synaptic plasticity in the hippocampus by promoting AMPA receptor trafficking to synapses. It preserves hippocampal synapse integrity and prevents neuronal cell ...
T81038	TAT-DEF-Elk-1 TFA	TDE TFA
	TAT-DEF-Elk-1 TFA (TDE TFA) is a cell-penetrating peptide that inhibits Elk-1 by mimicking its DEF domain and disrupting its function. It effectively blocks Elk-1 phosphorylation and its subsequent nuclear translocation,...
T38169	LY 341495 disodium salt
	Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 Fitzjohn et al (1998) The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mG...
T36679	Rp-cAMPS sodium salt
	Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis b...
T37582	Ganglioside GM1 Mixture (ovine) (ammonium salt)
	Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched i...

Compounds

Rhosin hydrochloride

T16745

Synonym:

Target: Apoptosis, Rho, Ras

Cardiogenol C

T2161

Synonym:

Target: Wnt/beta-catenin

Cardiogenol C hydrochloride

T8005

Synonym: Cardiogenol C HCl,Cardiogenol C

Target: Wnt/beta-catenin

Cutamesine dihydrochloride

T3597

Synonym: AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride

Target: Sigma receptor

Neurogranin (48-76), mouse

Synonym: Caerulein precursor fragment

TAT-DEF-Elk-1 TFA (1220751-16-5 free base)

TP2157L

Synonym: TDE TFA,TAT-DEF-Elk-1 TFA

LY 341495 disodium salt

Ganglioside GM1 Mixture (ovine) (ammonium salt)

T37582

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T82339	Gangliotetraose	Gg4
	Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated...

Natural Products

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-05510	BDNF Protein, Mouse, Recombinant (His)	Mouse	HEK293
	BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. B...
TMPY-03967	BTN3A3 Protein, Human, Recombinant (His)	Human	HEK293
	The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. The butyrophilin 3 (BTN3) receptors a...
TMPK-00758	IgE Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of which are mediated through its two Fc receptors, FcεRI and CD23 (FcεRII). IgE and its interactions with these receptors are the...
TMPJ-00135	BDNF Protein, Human/Murine/Rat, Recombinant	Human,Mouse,Rat	E. coli
	Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I...
TMPY-04779	BTN3A2 Protein, Human, Recombinant (His)	Human	HEK293
	The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tu...
TMPY-05343	CD47 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-04935	CD47 Protein, Human, Recombinant (aa 1-139, His)	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-02231	TrkB Protein, Mouse, Recombinant (His)	Mouse	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-04683	CD47 Protein, Human, Recombinant	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-00751	TrkB Protein, Human, Recombinant (His)	Human	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-03093	CD47 Protein, Rat, Recombinant (His)	Rat	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-05191	CD47 Protein, Human, Recombinant, Biotinylated	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-05276	CD47 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-04810	CD47 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-02521	HIST3H2A Protein, Human, Recombinant	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPH-03146	LAMP5 Protein, Pongo abelii, Recombinant (His & Myc)	Pongo abelii	E. coli
	Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
TMPH-01770	Neurotrypsin Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
TMPH-03251	BDNF Protein, Rat, Recombinant (His)	Rat	E. coli
	Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous sys...
TMPH-02278	PTPN5 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
TMPH-02187	Tenascin Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown o...
TMPH-01036	Caprin-1/CAPRIN1 Protein, Human, Recombinant (His)	Human	Baculovirus
	May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs...
TMPH-01754	L1CAM Protein, Human, Recombinant (His & Myc)	Human	HEK293
	Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neu...
TMPH-01663	GRM5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Sign...
TMPY-01692	NETO1 Protein, Human, Recombinant (His)	Human	HEK293
	Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR...
TMPY-02106	GAP43 Protein, Human, Recombinant (His)	Human	HEK293
	Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / G...
TMPH-02443	Tau Protein, Rhesus macaque, Recombinant (His & SUMO)	Rhesus	E. coli
	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane com...
TMPH-01683	Tau Protein, Human, Recombinant (HEK293, His)	Human	HEK293
	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane com...
TMPH-02444	Tau Protein, Rhesus macaque, Recombinant (His)	Rhesus	HEK293
	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane com...
TMPK-00670	IgE Protein, Cynomolgus, Recombinant (His & Avi)	Cynomolgus	HEK293
	Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of which are mediated through its two Fc receptors, FcεRI and CD23 (FcεRII). IgE and its interactions with these receptors are the...
TMPK-01048	Aggrecan Protein, Human, Recombinant (His)	Human	HEK293
	Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articul...
TMPK-00780	IgE Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of which are mediated through its two Fc receptors, FcεRI and CD23 (FcεRII). IgE and its interactions with these receptors are the...
TMPJ-00295	NgR Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Nogo Receptor (NgR) is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family. Human NgR is predominantly expressed in neurons and their axons in the central nervous systems. As a recept...
TMPY-04019	BTN3A3 Protein, Human, Recombinant (mFc)	Human	HEK293
	The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. The butyrophilin 3 (BTN3) receptors a...
TMPK-00779	IgE Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293
	Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of which are mediated through its two Fc receptors, FcεRI and CD23 (FcεRII). IgE and its interactions with these receptors are the...
TMPH-02458	PRNP Protein, Mesocricetus auratus, Recombinant (His & Myc)	Mesocricetus auratus	E. coli
	Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an ...
TMPH-01366	GABRA1 Protein, Human, Recombinant (His)	Human	E. coli
	Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergi...
TMPY-04155	NCAM2 Protein, Human, Recombinant (His)	Human	HEK293
	NCAM2 is a member of the immunoglobulin superfamily of cell adhesion molecules (IgCAMs). The neural cell adhesion molecule 2 (NCAM2) is encoded by a gene on chromosome 21 in humans. Neural cell adhesion molecules 2 (NCAM...
TMPJ-00883	EGR1 Protein, Human, Recombinant (His)	Human	E. coli
	EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The produc...
TMPY-03340	MAP1LC3A Protein, Human, Recombinant (His)	Human	E. coli
	LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between mic...
TMPY-03430	RheB Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	RHEB is a recently discovered member of the Ras superfamily that may be involved in neural plasticity. This function is novel and not typically associated with the Ras proteins. RHEB gene is a member of the small GTPase ...
TMPY-04151	NCAM2 Protein, Human, Recombinant (hFc)	Human	HEK293
	NCAM2 is a member of the immunoglobulin superfamily of cell adhesion molecules (IgCAMs). The neural cell adhesion molecule 2 (NCAM2) is encoded by a gene on chromosome 21 in humans. Neural cell adhesion molecules 2 (NCAM...
TMPY-00479	Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPY-04237	Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 176-240, His)	Canine	HEK293
	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPY-02600	NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc)	Human	HEK293
	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPY-05813	Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated	Human	HEK293
	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPY-03903	Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 19-240, His)	Canine	HEK293
	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPY-00031	Neuregulin-1/NRG1 Protein, Human, Recombinant (His)	Human	HEK293
	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPY-02720	NRG1 alpha Protein, Human, Recombinant (hFc)	Human	HEK293
	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPY-04088	Neuregulin-1/NRG1 Protein, Canine, Recombinant	Canine	HEK293
	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPJ-00614	CD47 Protein, Rhesus macaque, Recombinant (His & Flag)	Rhesus Macaque	Human Cells
	CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD)...
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