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  • Leukotriene Receptor
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Results for "

leukotriene

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    252
    TargetMol | Inhibitors_Agonists
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    1
    TargetMol | Dye_Reagents
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    24
    TargetMol | Natural_Products
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    TargetMol | Inhibitors_Agonists
Leukotriene C4
LTC4, Leukotriene C
T2568772025-60-6In house
Leukotriene C4 (LTC4) is an arachidonate lipid mediator that regulates leukocyte recruitment and function at sites of inflammation.Leukotriene C4 is a mediator of bronchoconstriction, mucus hypersecretion, and eosinophilia, and has a mediating role in urticaria.
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20 days
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Leukotriene D4
LTD4
T3812873836-78-9In house
Leukotriene D4 (LTD4) is a potent pro-inflammatory mediator formed from arachidonic acid, a bronchoconstrictor, and induces osteoclast senescence.Leukotriene D4 induces transcriptional activity of potentially oncogenic genes and can be used in the study of asthma.
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20 days
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Leukotriene E4
LTE4
T4087075715-89-8In house
Leukotriene E4 (LTE4) (LTE4) is produced by the action of dipeptidyl peptidase on LTD4 and is a component of the Slow Reactive Substance of Anaphylaxis (SRS-A).LTE4 is present in plasma and urine and can be used to detect asthma.
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Leukotriene B4
5(S),12(R)-DiHETE
T1404571160-24-2
Leukotriene B4 (LTB4) is a compound derived from arachidonic acid via the 5-lipoxygenase pathway that mediates certain inflammatory and immune responses. Leukotriene B4 induces neutrophil extracellular traps that impede the clearance of Pneumocystis japonicus.
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5-Aminosalicylic Acid
Mesalazine, Mesalamine, 5-ASA
T064689-57-6
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
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TargetMol | Inhibitor Hot
Bestatin
Ubenimex
T125758970-76-6
Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage, and bone marrow stem cell as well as stimulates the release of interleukin-1 and -2, thus further enhances its antitumor activity.
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7-10 days
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Bestatin hydrochloride
Ubenimex hydrochloride
T352965391-42-6
Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN) CD13 and aminopeptidase B.
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Chamazulene
Dimethulene
T19791529-05-5
Chamazulene (Dimethulene) is a terpenoid obtained from Matricaria chamomilla L.. It possesses anti-inflammatory and antioxidant activity, inhibits leukotriene B4 formation and can be used in the study of melanoma.
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7-10 days
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γ-Linolenic Acid methyl ester
Methyl gamma-linolenate
T2150416326-32-2
γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.
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12-OxoETE
12-oxo-ETE, 12-KETE
T37972108437-64-5
12-OxoETE is an endogenous metabolite formed during the metabolism of arachidonic acid and is present in human platelets and Aplysia nervous tissue .12-KETE induces transient changes and aggregation of intracytoplasmic free calcium ion concentration via leukotriene B4 (LTB4) receptor or coactivation sequences to achieve a rapid and dose-dependent increase.
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Paraxanthine
1,7-DIMETHYLXANTHINE
T4973611-59-6
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is structurally similar to caffeine and possibly mediates the physiological effects of caffeine. Also Paraxanthine acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-α and leukotriene synthesis. In addition, Paraxanthine acts as a Na+ K+ ATPase enzymatic effector.
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5-O-Demethylnobiletin
5-DEMETHYLNOBILETIN
T57142174-59-6
5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.
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Bestatin trifluoroacetate
T62258223763-80-2
Bestatin trifluoroacetate (Ubenimex trifluoroacetate) is a CD13 (Aminopeptidase N) APN and leukotriene A4 hydrolase inhibitor that is often used in cancer research.
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1-2 weeks
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Tryptanthrin
T778613220-57-0
Tryptanthrin is a natural DNA gyrase inhibitor.
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11-​Keto-​beta-​boswellic acid
11-Keto-beta-boswellic acid
TN118217019-92-0
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenase
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Britannilactone diacetate
1,6-O,O-Diacetylbritannilactone
TN25111286694-67-4
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro
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1-Methyl-2-nonylquinolin-4(1H)-one
TN255268353-24-2
1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.
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Morolic acid
TN4584559-68-2
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro
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Stilbostemin B
TN5070162411-67-8
Stilbostemin A, stilbostemin B , stilbostemin D , stilbostemin F , and stilbostemin G show structure-dependent inhibition of leukotriene biosynthesis with IC(50) values ranging from 3.7 to >50 microM.
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Triptinin B
TN5180189389-05-7
Triptinin A and triptinin B are leukotriene D4 antagonist constituents.
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1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone
(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one
TN6057120693-49-4
(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one shows strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes, and it is very effective against mycobacteria.
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Hinokiol
8,11,13-Abietatriene-3,12-diol
TN7307564-73-8
Hinokiol exhibits anti-inflammatory activity by significantly inhibiting 5-hydroxy-eicosa-tetra-enoic acid (5-HETE) and leukotriene B(4) (LTB4) formations. Additionally, it demonstrates potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
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9,11-Dehydro-beta-boswellic acid
TN7347471-65-8
9,11-Dehydro-β-boswellic acid is a compound with urease inhibitory activity and acts as an inhibitor of 5-lipoxygenase (5-LO), a critical enzyme in leukotriene biosynthesis.
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Bilirubin diglucuronide
TN894617459-92-6
Bilirubindiglucuronide is a metabolite of Bilirubin. Bilirubin diglucuronide can inhibit the MRP1 2-mediated, ATP-dependent transport of leukotriene C4 (LTC4) in membrane vesicles.
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