l tryptophan

L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid) and of INDOLE ALKALOIDS in plants. It can be a precursor to NIACIN, although inefficiently in mammals.

Caffeine N-Acetyl-L-Tryptophan is a caffeine salt that stimulates the nervous system and causes vasodilation.

N-Acetyl-L-tryptophan-d3 is the deuterium-labeled analogue of N-Acetyl-L-tryptophan. This compound functions as an antagonist of the neurokinin receptor (NK-1R), inhibiting the binding of Substance P (SP) to NK-1R and providing neuroprotective effects that improve memory impairment and motor dysfunction. Additionally, N-Acetyl-L-tryptophan acts as an inhibitor of mitochondrial cytochrome c (Cytochrome c), offering antioxidant and anti-inflammatory benefits by reducing IL-1β expression and inhibiting caspase-1 activation. N-Acetyl-L-tryptophan shows potential for research in neurodegenerative and inflammatory disease contexts.

2-Hydroxy L-tryptophan hydrochloride is a naturally occurring amino acid and a precursor to 5-hydroxytryptamine (serotonin). It can increase serotonin production in the brain.

2-α-D-Mannopyranosyl-L-tryptophan is a naturally occurring C-glycosyl amino acid and serves as a biomarker of renal function.

JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.

N-Valyltryptophan (Val-trp) is an incomplete breakdown product of protein catabolism or protein digestion.

Oglufanide (H-Glu-Trp-OH) is a naturally occurring thymic immunomodulator that inhibits vascular endothelial growth factor (VEGF).

N-Acetyl-L-tryptophan (N-acetyltryptophan) is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).

Ac-DL-Trp-OH (N-Acetyl-DL-tryptophan) was study for its possible anti- inflammatory and antinociceptive activities from the extraction of a Turkish plant, Salsola grandis.

H-Phe-Trp-OH (Phenylalanyland tryptophan) is a small molecular dipeptide compound involved in protein synthesis in the body.

N-Cbz-DL-tryptophan is a cholecystokinin receptor antagonist, abolished the response of the isolated heart to CCK-8.

Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity that inhibits the homodimerization of STAT3 in the cytoplasm, thereby inhibiting STAT3 signaling. It can be used for studying immune-sensitive diseases and HCV infections.

Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.

Golotimod TFA (SCV 07 TFA) is a dipeptide exhibiting immunomodulatory and antibacterial activity. It reduces recurrent lesions caused by HSV-2, alleviates radiation-induced oral mucositis, and inhibits the homodimerisation of STAT3 molecules in the cytoplasm.

RG108 (N-Phthalyl-L-tryptophan) is a DNA methyltransferase inhibitor with an IC50 of 115 nM.

5-Fluoro-L-tryptophan is a competitive inhibitor of the vesicular glutamate transporter (VGLUT). It holds potential for research related to disorders involving neurotransmitter systems.

(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.

F4-Trp (4,5,6,7-Tetrafluoro-L-tryptophan) is a ligand specifically targeting the α3β4 subtype of nicotinic acetylcholine receptors (α3β4nAChR). This compound holds potential for research in neurotransmission, addiction, and related conditions, including neurological disorders.

(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg, induction of IDO1 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg, antitumor activity against mouse LLC cells allografted in C57BL/6 mouse, antiproliferative activity against mouse LLC cells at 50 uM.

Tryptophan, N-indol-3-ylacetyl- (Indole-3-acetyl-L-tryptophan) is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may also be used in the synthesis of β-D-galactosidase and β-D-glucosidase inhibitors.

(S)-2-Amino-3-(6-chloro-1H-indol-3-yl)propanoic acid (6-Chloro-L-tryptophan) is a tryptophan derivative serving as a substrate for KtzQ, exhibiting inhibitory activity against MDM2 protein (IC50=0.005 µM).

1,1'-Ethylidene-bis-(L-tryptophan) is a potential impurity in L-tryptophan commercial products, promoting EoL-3 eosinophilic leukemia cell proliferation, enhancing eosinophil cationic protein release from human peripheral blood eosinophils, and boosting IL-5 production in human T cells. At 40 µg/kg, it triggers fascia thickening, mast cell infiltration, inflammation, and fibrosis in mouse superficial adipose and panniculus carnosus tissues, serving as an eosinophilia-myalgia syndrome research model. 1,1'-Ethylidene-bis-(L-tryptophan) is therefore used in immunotoxicology and eosinophil biology research systems to investigate cytokine-driven eosinophilic activation, mast cell infiltration pathways, and fibrosis-associated inflammatory remodeling in in vivo disease modeling contexts.

5-Hydroxy-L-tryptophan-4,6,7-D3 is L-5-Hydroxytryptophan labeled with 2H. L-5-Hydroxytryptophan (L-5-HTP) is a dietary supplement and a precursor to serotonin, which inhibits the IFN-γ induced PD-L1 expression. It promotes anti-tumor immunity and is used in research on migraine and depression.