axon

Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.

Daraxonrasib (RMC-6236) is an orally effective and novel triple complex RAS (ON) MULTI inhibitor, which is a potent non covalent inhibitor of multiple RAS variants in GTP binding state. RMC-6236 has anti-tumor activity and can be used in research related to RAS driven tumors. With rich experience in compound synthesis, we can provide fast customized synthesis services for this product according to your research needs.

Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.

Ceftriaxone Sodium is a broad-spectrum β-lactam tertiary cephalosporin antibiotic with anti-inflammatory, antitumor, antibacterial, and antioxidant activities.Ceftriaxone Sodium is a covalent GSK3β and Aurora B inhibitor used in the study of sepsis and infective endocarditis.

Isaxonine has a wide range of applications in life science related research.

Ceftriaxone is a novel cephalosporin antibiotic with antimicrobial activity against most Gram-positive and Gram-negative bacteria.Ceftriaxone also exhibits anti-inflammatory and antioxidant activity.

Ceftriaxone-13C2,D3 triethylammonium salt is a 13C and deuterium-labeled form of Ceftriaxone. Ceftriaxone (Ro 13-9904 free acid) is a broad-spectrum, third-generation β-lactam cephalosporin antibiotic with effective antibacterial activity against various Gram-negative and Gram-positive bacteria. It acts as a covalent inhibitor of GSK3β, with an IC50 value of 0.78 mM, and also inhibits Aurora B. Additionally, Ceftriaxone exhibits anti-inflammatory, antitumor, and antioxidant activities. It is applicable in research related to bacterial infections and meningitis.

Ceftriaxone-D3 isodium) is the deuterated form of Ceftriaxone (T75295). Ceftriaxone, a third-generation cephalosporin antibiotic, exhibits excellent antimicrobial activity against various Gram-negative bacteria and reasonable activity against most Gram-positive bacteria. It also possesses anti-inflammatory and antioxidant properties.

Ceftriaxone sodium hydrate (Standard) is a reference standard for research and analysis in studies involving Ceftriaxone sodium hydrate. Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.

Ceftriaxone Disodium Salt-[13C,D3] (Standard) is a reference standard of Ceftriaxone Disodium Salt-[13C,D3] intended for quantitative analysis, quality control, and related biochemical research applications.

Naltrexone hydrochloride (Naltrexone HCl) is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism.

Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.

Adrenochrome (Adraxone) is a cytotoxic molecule that can be used to kill bacteria. Adrenochrome is an oxidized product of Epinephrine. Adrenochrome is a coronary systolic compound that acts on rat hearts and is associated with cardiotoxicity and can be used to determine superoxide dismutase activity. Adrenochrome is a potential psychotropic drug for the study of nervous system diseases.

Levobetaxolol hydrochloride ((S)-Betaxolol hydrochloride) is a beta-adrenergic receptor inhibitor (beta blocker), used to lower the pressure in the eye in treating conditions such as glaucoma.

Djalonensone (Alternariol monomethyl ether), an Alternaria toxin, is a strong mutagen in Escherichia coli strain ND-160. Alternariol monomethyl ether has genotoxic properties, it can cause oxidative DNA damage. It also possesses cytotoxic and immunosuppressive properties.

Dehydronitrosonisoldipine is an inhibitor of sterile α and TIR motif-containing 1 and can be used in studies about neurodegenerative disorders. Dehydronitrosonisoldipine inhibits axon degenration and the Vincristine-activated cADPR production in neurons.

Reserpine (Serpalan) is an alkaloid isolated from the root of Rauwolfia serpentina. As an inhibitor of vesicular monoamine transporter 2 (VMAT2), it suppresses the uptake of norepinephrine into storage vesicles, leading to depletion of catecholamines and serotonin in central and peripheral nerve terminals. It has antihypertensive and antipsychotic effects and can be used to induce gastric ulcer and depression models.

SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.

Reserpine hydrochloride is the salt form of Reserpine and acts as an inhibitor of vesicular monoamine transporter 2 (VMAT2). It blocks the uptake of norepinephrine into storage vesicles, leading to the depletion of catecholamines and serotonin at central and peripheral nerve terminals. It has antihypertensive and antipsychotic properties and is commonly used to induce models of gastric ulcer and depression.

5,7-Dihydroxytryptamine (5,7-DHT) hydrobromide is a neurotoxin that selectively targets and damages serotonergic (5-HT) and noradrenergic (NE) neurons in the brain. As an autofluorescent serotonin derivative, 5,7-Dihydroxytryptamine hydrobromide binds to high-affinity transporters of these neurons and is selectively uptaken, leading to intracellular metabolism that generates reactive oxygen species. This process results in axon terminal degeneration and depletion of neurochemicals. It is utilized in neuroscience research.

DLK-IN-2 is a selective inhibitor of DLK and acts as a neuroprotective agent. It shows no significant inhibitory effect on CYP enzymes 3A4, 2D6, and 2C9. DLK-IN-2 inhibits acute axonal palmitoylation of DLK, blocks DLK-dependent prodegenerative axon-to-cell body retrograde signaling, and suppresses c-Jun phosphorylation. It is used for studying mechanisms in neurodegenerative diseases.

(S,S)-SARM1-IN-9 (Compound MY-13A) is a stereoselective SARM1 inhibitor with covalent binding properties. It covalently modifies cysteine-311 within the auto-regulatory ARM domain of wild-type SARM1, thereby blocking NADase activity without inhibiting SARM1C311A or SARM1C311S mutants. This compound also prevents axonal degeneration in primary rodent dorsal root ganglion neurons induced by vacor and vincristine. (S,S)-SARM1-IN-9 is applicable for the study of axon degeneration-dependent neurological diseases, including chemotherapy-induced peripheral neuropathy.

SARM1-IN-9 (Compound MY-13B) is a stereoselective inhibitor of SARM1, useful for research in axon degeneration-dependent neurological disorders.

Cyclo(L-Phe-L-Val) is a metabolite of the sponge bacterium Pseudoalteromonas sp. NJ6-3-1, capable of autoinducing the production of antibacterial substances active against S. aureus at low cell density. It induces neurite outgrowth and branching of chick cortical neurons in vitro at concentrations of 16 and 32 μM, increases phosphorylation of the PI3K substrate Akt, and this induction can be blocked by the PI3K inhibitor LY294002. Additionally, it enhances axon sprouting of calcitonin gene-related protein positive (CGRP+) primary afferents in the spinal cord post-crush injury and of serotonin neurons in the uninjured spinal cord. Cyclo(L-Phe-L-Val) is also a bitter taste component of cocoa and roasted coffee.