csc — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23587	8-CSC	8 CSC,CSC
	8-CSC is a dual agent endowed with good hMAO-B inhibitory activity (Ki: 235 nM in baboon liver mitochondria) and A2A affinity (Ki: 36 nM in rat brain striatal membranes receptor).
T19971	Cyclosporin C	CsC,Cs-C,Cyclosporin-C	Antiviral , Antifungal
	Cyclosporin C (Cs-C) is a fungal metabolite against filamentous phytopathogenic fungi. Cyclosporin C has antifungal, antiviral, and immunosuppressant properties.		Antiviral , Antifungal
T73995	EGFR/CSC-IN-1		EGFR
	EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential applications in triple-negative breast cancer research.		EGFR
T0365	Thioridazine hydrochloride	Mellaril,Aldazine	Apoptosis , Potassium Channel , Dopamine Receptor , 5-HT Receptor , Antibacterial , Adrenergic Receptor , Autophagy
	Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T33519	MTOB	α-keto-γ-Methylthiobutyric acid,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid	Others
	MTOB (α-keto-γ-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, lea...		Others
T10904	CWP232228		Wnt/beta-catenin
	CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t...		Wnt/beta-catenin
T20974	IR-780 Iodide	IR 780 iodide	Others
	IR-780 Iodide (IR 780 iodide), a near‐infrared fluorescent dye, is used for the exclusive characterization of human CSCs through the HIF‐1α/glycolysis dependent mitochondrial transporter ABCB10's activity.		Others
T24879	Thioxodihydroquinazolinone-19	Thioxodihydroquinazolinone19
	In platinum-resistant A2780cis human ovarian cancer cells, thioxodihydroquinazolinone-19 is an inducer of apoptotic cell death. It acts by exhibiting a strong inhibitory effect in ovarian CSC-LCs in combination with cisp...
T61885	Sulconazole
	Sulconazole is an imidazole compound with effective antifungal effect. Sulconazole vs. NF- κ B/IL-8 signal pathway has blocking effect and inhibiting effect on the formation of cancer stem cells (CSC). Sulconazole has in...
T71998	673-A
	673-A is an aldehyde dehydrogenase (ALDH1A) inhibitor that depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. 673-A triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupli...
T74092	Cyanine5 alkyne
	Cyanine5 alkyne (Alkyne-Cy5), a fluorescent dye, labels azide proteins for analyzing post-translational modifications, such as glycosylation. Additionally, it serves as a mitochondrial OXPHOS inhibitor, curtailing the pr...
T21762	LDN-211904
	LDN-211904 oxalate (compound 32), a potent and selective EphB3 inhibitor, demonstrates an IC50 of 0.079 μM and shows good metabolic stability in mouse liver microsomes. When combined with cetuximab, it may effectively in...
T39792	AMPC
	AMPC, a powerful and efficient inhibitor of TFF3, demonstrates inhibitory effects on cell proliferation, survival, oncogenicity, and CSC-like behavior in TFF3-positive CMS4 CRC cells. It acts as a promising standalone an...
T4134L	OTS514	OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514	Apoptosis , TOPK
	OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen...		Apoptosis , TOPK
T72658	CRIPGBM chloride
	cRIPGBM chloride is an orally active, proapoptotic compound derived from glioblastoma multiforme (GBM) cancer stem cells (CSCs). It specifically targets receptor-interacting protein kinase 2 (RIPK2) to trigger caspase 1-...