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Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands.

  • Decitabine
    T15082353-33-5
    Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.
    • $30
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  • Gemcitabine
    T025195058-81-4
    Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
    • $34
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  • 5-Fluorouracil
    T098451-21-8
    5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibition of thymidylate synthase. 5-Fluorouracil causes apoptosis and autophagy.
    • $30
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  • Ganciclovir
    T068882410-32-0
    Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
    • $51
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  • 1-Methylcytosine
    T100191122-47-0In house
    1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired with isoguanine.
    • $29
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  • Stavudine
    T14043056-17-5
    Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
    • $33
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  • 7-Methylxanthine
    T0543552-62-5
    7-Methylxanthine is a methyl derivative of xanthine, the purine component of human urinary calculi.7-Methylxanthine has an affinity for adenosine receptors.7-Methylxanthine is a methyl derivative of xanthine, the purine component of human urinary calculi.7-Methylxanthine has an affinity for adenosine receptors.
    • $39
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  • dGTP
    T401922564-35-4
    dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
    • $148
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  • 2'-Deoxy-2'-fluoroarabinoadenosine
    TNU008520227-41-2
    2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue with extensive anti-tumor activity and can be used for the study of tumor diseases.
    • $30
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  • Deoxycytidine triphosphate
    T75202056-98-6
    Deoxycytidine triphosphate is a nucleoside triphosphate.It is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    • $79
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  • 2'-O-(2-Azidoethyl)adenosine
    TNU01782226475-42-7
    2'-O-(2-azidoethyl)adenosine is a purine nucleoside analog with potential antitumor activity. The activity of 2'-O-(2-azidoethyl)adenosine was associated with inhibition of DNA synthesis and apoptosis.
    • $146
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  • 5-Aminouridine
    T135112149-76-0
    5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.
    • $50
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  • 1,4-Dideoxy-1,4-epithio-D-ribitol
    TNU0839190315-43-6
    1,4-Dideoxy-1,4-epithio-D-ribitol is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses a broad spectrum of antitumor activity.1,4-Dideoxy-1,4-epithio-D-ribitol induces apoptosis through inhibition of DNA synthesis.
    • $195
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  • 3'-Deoxy-3'-fluoroguanosine
    TNU0091123402-21-1
    3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons. 3 '-Deoxy-3' -fluoroguanosine is used to treat viral hepatitis, cancer and other diseases.
    • $40
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  • Peldesine
    T12399133432-71-0In house
    Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in research on cutaneous T-cell lymphoma, psoriasis and HIV infection.
    • $116
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  • Orotic acid zinc
    T327168399-76-8
    Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.
    • $37
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  • 2',5-Difluoro-2'-deoxy-1-arabinosyluracil
    TNU018769123-95-1
    2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic and antihypertensive activity, which can be used to study anticonvulsant and anxiety disorders.
    • $30
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  • 8-Azaguanosine
    TNU05412133-80-4
    8-Azaguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity and is used in the study of a variety of tumor diseases.
    • $195
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  • 5-Bromo-2’,3’,5’-tri-O-acetyluridine
    TNU0802105659-32-3
    5-Bromo-2’,3’,5’-tri-O-acetyluridine is a purine nucleoside analog that is being explored to improve Alzheimer’s and Parkinson’s diseases.
    • $47
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  • 2'-O-Methyl-2-thiouridine
    TNU0130113886-72-9
    2'-O-Methyl-2-thiouridine is a purine nucleoside analogue present in synthetic thermophilic bacterial tRNAs. 2'-O-Methyl-2-thiouridine is more selective for A than unmodified U.
    • $195
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  • 2’-Deoxy-N4-methylcytidine
    TNU120522882-02-6
    2’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.
    • $64
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  • N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite
    TNU1119207347-42-0
    N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite is an adenine nucleoside analog with potential vasodilator activity and anticancer activity for cancer research.
    • $195
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  • (S)-GNA-T-phosphoramidite
    TNU1431168332-13-6
    (S)-GNA-T-phosphoramidite is a nucleoside analog commonly used in the synthesis of other active compounds.
    • $46
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  • 2′-C-Methyl-6-O-methylinosine
    TNU0810565450-78-4
    2′-C-Methyl-6-O-methylinosine (2′-C-Methyl-6-O-methylinosine) is a hypoxanthine analog with a wide range of physical activities for the study of a variety of tumor diseases.
    • $195
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  • 8-Azahypoxanthine
    T201022683-90-1
    8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.
    • $40
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  • Ascamycin
    T1432991432-48-3In house
    Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp. It shows selective antibacterial activity against Xanthomonas species and inhibits Xanthomonas citri, Xanthomonas oryzae and phage with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL respectively.
    • $350
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  • Rabacfosadine
    T16716859209-74-8In house
    Rabacfosadine (GS-9219) is a novel dual pre-drug of the acyclic nucleotide phosphonate PMEG to tumor lymphocytes for the study of lymphoma.
    • $158 TargetMol
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  • Trifluridine
    T142870-00-8
    Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity.
    • $30
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  • 6-Mercaptopurine hydrate
    T22016112-76-1
    6-Mercaptopurine hydrate (6-Mercaptopurine monohydrate) is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
    • $38
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  • N2-Methylguanosine
    T75142140-77-4
    N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA's
    • $53
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  • Tipiracil hydrochloride
    T2366183204-72-0
    Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI). Tipiracil hydrochloride is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.
    • $30
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  • Clofarabine
    T0297123318-82-1
    Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
    • $36
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  • Vidarabine
    T15065536-17-4
    Vidarabine (Adenine Arabinoside) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
    • $38
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  • Fludarabine
    T103821679-14-1
    Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.
    • $50
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  • 5-Azacytidine
    T1339320-67-2
    5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autophagy and has antitumor activity.
    • $33
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  • LY2334737
    T4061892128-60-8
    LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
    • $64
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  • Carmofur
    T130761422-45-5
    Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
    • $34
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  • Adenosine
    T085358-61-7
    Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
    • $46
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  • 5-BrdU
    T679459-14-3
    5-BrdU (Broxuridine) , a nucleoside analog, are used in the detection of proliferating cells and competes with thymidine for incorporation into DNA.
    • $30
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  • 7-Methylguanosine
    T731920244-86-4
    7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor (IC50 : 87.8 ± 7.5 μM).
    • $30
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  • Trifluridine/tipiracil hydrochloride mixture
    T3658733030-01-8
    Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.
    • $33
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  • 6-Mercaptopurine
    T001050-44-2
    6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
    • $31
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  • 3-Methylcytidine
    T73512140-64-9
    3-Methylcytidine as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
    • $32
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  • Cytarabine
    T1272147-94-4
    Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
    • $30
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  • Gemcitabine hydrochloride
    T6069122111-03-9
    Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
    • $35
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  • N6-(p-Methoxybenzyl)adenosine
    TNU043023666-24-2
    N6-(p-Methoxybenzyl)adenosine is an adenosine analog that shows in vitro antiproliferative activity in U87MG glioma cells and immunogenicity in isolated γδ T cells derived from stimulated peripheral blood mononuclear cells (PBMCs).
    • $195
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  • Lysidine
    T21052534-26-9
    Lysidine (2-Methyl-2-iMidazoline) is a nucleoside rarely seen outside of tRNA. Lysidine has better translation fidelity.
    • $50
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  • DMT-2′Fluoro-dU Phosphoramidite
    T38958146954-75-8
    DMT-2′Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) can be used to modify nucleosides.
    • $29
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  • ddUTP (lithium), 100mM in H2O
    T82597
    ddUTP (lithium), at a concentration of 100mM in H20, serves as a nucleotide analog capable of being integrated into DNA, RNA, or other nucleic acids. It is applicable in DNA/RNA hybridization experiments including Southern and Northern blots.
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  • Ac-rC Phosphoramidite
    T36687121058-88-6
    Ac-rC Phosphoramidite can modify phosphodisulfide oligonucleotides.
    • $29
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