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Cell Cycle/CheckpointNucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands.
- DecitabineT15082353-33-5Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.
- $30
SizeQTY
Cited - GemcitabineT025195058-81-4Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
- $34
SizeQTY Cited - 5-FluorouracilT098451-21-85-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibition of thymidylate synthase. 5-Fluorouracil causes apoptosis and autophagy.
- $30
SizeQTY Cited - GanciclovirT068882410-32-0Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
- $51
SizeQTY Cited - 1-MethylcytosineT100191122-47-0In house1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired with isoguanine.
- $29
SizeQTY - 7-MethylxanthineT0543552-62-57-Methylxanthine is a methyl derivative of xanthine, the purine component of human urinary calculi.7-Methylxanthine has an affinity for adenosine receptors.7-Methylxanthine is a methyl derivative of xanthine, the purine component of human urinary calculi.7-Methylxanthine has an affinity for adenosine receptors.
- $39
SizeQTY - StavudineT14043056-17-5Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
- $33
SizeQTY - dGTPT401922564-35-4dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
- $148
SizeQTY - 2'-Deoxy-2'-fluoroarabinoadenosineTNU008520227-41-22'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue with extensive anti-tumor activity and can be used for the study of tumor diseases.
- $30
SizeQTY
- Deoxycytidine triphosphateT75202056-98-6Deoxycytidine triphosphate is a nucleoside triphosphate.It is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
- $79
SizeQTY - 2'-O-(2-Azidoethyl)adenosineTNU01782226475-42-72'-O-(2-azidoethyl)adenosine is a purine nucleoside analog with potential antitumor activity. The activity of 2'-O-(2-azidoethyl)adenosine was associated with inhibition of DNA synthesis and apoptosis.
- $146
SizeQTY - 1,4-Dideoxy-1,4-epithio-D-ribitolTNU0839190315-43-61,4-Dideoxy-1,4-epithio-D-ribitol is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses a broad spectrum of antitumor activity.1,4-Dideoxy-1,4-epithio-D-ribitol induces apoptosis through inhibition of DNA synthesis.
- $195
SizeQTY - 3'-Deoxy-3'-fluoroguanosineTNU0091123402-21-13'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons. 3 '-Deoxy-3' -fluoroguanosine is used to treat viral hepatitis, cancer and other diseases.
- $40
SizeQTY - 5-AminouridineT135112149-76-05-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA. 5-Aminouridine inhibits the growth of tumors, viruses, and fungi.
- $50
SizeQTY - Orotic acid zincT327168399-76-8Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.
- $37
SizeQTY - 2',5-Difluoro-2'-deoxy-1-arabinosyluracilTNU018769123-95-12',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic and antihypertensive activity, which can be used to study anticonvulsant and anxiety disorders.
- $30
SizeQTY - 8-AzaguanosineTNU05412133-80-48-Azaguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity and is used in the study of a variety of tumor diseases.
- $195
SizeQTY - 5-Bromo-2’,3’,5’-tri-O-acetyluridineTNU0802105659-32-35-Bromo-2’,3’,5’-tri-O-acetyluridine is a purine nucleoside analog that is being explored to improve Alzheimer’s and Parkinson’s diseases.
- $47
SizeQTY - 2'-O-Methyl-2-thiouridineTNU0130113886-72-92'-O-Methyl-2-thiouridine is a purine nucleoside analogue present in synthetic thermophilic bacterial tRNAs. 2'-O-Methyl-2-thiouridine is more selective for A than unmodified U.
- $195
SizeQTY - PeldesineT12399133432-71-0In housePeldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in research on cutaneous T-cell lymphoma, psoriasis and HIV infection.
- $116
SizeQTY - 2’-Deoxy-N4-methylcytidineTNU120522882-02-62’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.
- $64
SizeQTY - N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramiditeTNU1119207347-42-0N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite is an adenine nucleoside analog with potential vasodilator activity and anticancer activity for cancer research.
- $195
SizeQTY - (S)-GNA-T-phosphoramiditeTNU1431168332-13-6(S)-GNA-T-phosphoramidite is a nucleoside analog commonly used in the synthesis of other active compounds.
- $46
SizeQTY - 2′-C-Methyl-6-O-methylinosineTNU0810565450-78-42′-C-Methyl-6-O-methylinosine (2′-C-Methyl-6-O-methylinosine) is a hypoxanthine analog with a wide range of physical activities for the study of a variety of tumor diseases.
- $195
SizeQTY - 8-AzahypoxanthineT201022683-90-18-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.
- $40
SizeQTY - AscamycinT1432991432-48-3In houseAscamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp. It shows selective antibacterial activity against Xanthomonas species and inhibits Xanthomonas citri, Xanthomonas oryzae and phage with MIC values of 0.4 μg mL, 12.5 μg mL and 12.5 μg mL respectively.
- $350
SizeQTY - RabacfosadineT16716859209-74-8In houseRabacfosadine (GS-9219) is a novel dual pre-drug of the acyclic nucleotide phosphonate PMEG to tumor lymphocytes for the study of lymphoma.
- $158
SizeQTY - $158
- N2-MethylguanosineT75142140-77-4N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA's
- $53
SizeQTY Cited - ClofarabineT0297123318-82-1Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
- $36
SizeQTY Cited - 6-Mercaptopurine hydrateT22016112-76-16-Mercaptopurine hydrate (6-Mercaptopurine monohydrate) is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
- $38
SizeQTY Cited - Tipiracil hydrochlorideT2366183204-72-0Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI). Tipiracil hydrochloride is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.
- $30
SizeQTY Cited - TrifluridineT142870-00-8Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity.
- $30
SizeQTY Cited - VidarabineT15065536-17-4Vidarabine (Adenine Arabinoside) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
- $38
SizeQTY Cited - LY2334737T4061892128-60-8LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
- $64
SizeQTY Cited - CarmofurT130761422-45-5Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
- $34
SizeQTY Cited - FludarabineT103821679-14-1Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.
- $50
SizeQTY Cited - 5-AzacytidineT1339320-67-25-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autophagy and has antitumor activity.
- $33
SizeQTY Cited - 7-MethylguanosineT731920244-86-47-Methylguanosine is a novel cNIIIB nucleotidase inhibitor (IC50 : 87.8 ± 7.5 μM).
- $30
SizeQTY Cited - 5-BrdUT679459-14-35-BrdU (Broxuridine) , a nucleoside analog, are used in the detection of proliferating cells and competes with thymidine for incorporation into DNA.
- $30
SizeQTY Cited - AdenosineT085358-61-7Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
- $46
SizeQTY Cited - 6-MercaptopurineT001050-44-26-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
- $31
SizeQTY Cited - 3-MethylcytidineT73512140-64-93-Methylcytidine as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
- $32
SizeQTY Cited - Trifluridine/tipiracil hydrochloride mixtureT3658733030-01-8Trifluridine tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.
- $33
SizeQTY Cited - Gemcitabine hydrochlorideT6069122111-03-9Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
- $35
SizeQTY Cited - CytarabineT1272147-94-4Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
- $30
SizeQTY Cited - DMT-2′Fluoro-dU PhosphoramiditeT38958146954-75-8DMT-2′Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) can be used to modify nucleosides.
- $29
SizeQTY - N6-(p-Methoxybenzyl)adenosineTNU043023666-24-2N6-(p-Methoxybenzyl)adenosine is an adenosine analog that shows in vitro antiproliferative activity in U87MG glioma cells and immunogenicity in isolated γδ T cells derived from stimulated peripheral blood mononuclear cells (PBMCs).
- $195
SizeQTY - LysidineT21052534-26-9Lysidine (2-Methyl-2-iMidazoline) is a nucleoside rarely seen outside of tRNA. Lysidine has better translation fidelity.
- $50
SizeQTY - ddUTP (lithium), 100mM in H2OT82597ddUTP (lithium), at a concentration of 100mM in H20, serves as a nucleotide analog capable of being integrated into DNA, RNA, or other nucleic acids. It is applicable in DNA/RNA hybridization experiments including Southern and Northern blots.
- Inquiry Price
SizeQTY - Ac-rC PhosphoramiditeT36687121058-88-6Ac-rC Phosphoramidite can modify phosphodisulfide oligonucleotides.
- $29
SizeQTY
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