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Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T5539 GS-443902 1355149-45-9
GS-443902
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
T21052 Lysidine 534-26-9 98%
Lysidine
Lysidine (2-Methyl-2-iMidazoline) is a nucleoside rarely seen outside of tRNA. Lysidine has better translation fidelity.
T78565 Dihydro-5-azacytidine acetate 2470972-18-8 98%
Dihydro-5-azacytidine acetate
Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1] [...
T79190 Homouridine 30685-57-5 98%
Homouridine
Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM). Moreover, the derivative of ho...
T79198 S-Gem 2169925-98-6 98%
S-Gem
S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR. Studies indicate that S-Gem exhibits lower cytotoxicity...
T82597 DdUTP (lithium), 100mM in H2O 98%
ddUTP (lithium), 100mM in H2O
ddUTP (lithium), at a concentration of 100mM in H20, serves as a nucleotide analog capable of being integrated into DNA, RNA, or other nucleic acids. It is appli...
TQ0006 Ethynylcytidine 180300-43-0 98%
Ethynylcytidine
Ethynylcytidine is a nucleoside antimetabolite.
T15378 Gemcitabine elaidate 210829-30-4 98%
Gemcitabine elaidate
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with ...
T0964 Floxuridine 50-91-9 99.96%
Floxuridine
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
T1600 Doxifluridine 3094-09-5 99.96%
Doxifluridine
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridi...
T12399 Peldesine 133432-71-0 99.95%
Peldesine
Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferat...
T1378 Tegafur 17902-23-7 99.95%
Tegafur
Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil ...
T0010 6-Mercaptopurine 50-44-2 99.94%
6-Mercaptopurine
6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting puri...
TNU0187 2',5-Difluoro-2'-deoxy-1-arabinosyluracil 69123-95-1 99.94%
2',5-Difluoro-2'-deoxy-1-arabinosyluracil
2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic a...
T19382 Isoguanine 3373-53-3 99.93%
Isoguanine
Isoguanine is a purine base that is an isomer of guanine. A building block in organic synthesis.
T0746 Orotic acid 65-86-1 99.93%
Orotic acid
Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
T1272 Cytarabine 147-94-4 99.92%
Cytarabine
Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophag...
T0853 Adenosine 58-61-7 99.92%
Adenosine
Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
T40192 DGTP 2564-35-4 99.9%
dGTP
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8...
TNU0130 2'-O-Methyl-2-thiouridine 113886-72-9 99.89%
2'-O-Methyl-2-thiouridine
2'-O-Methyl-2-thiouridine is a purine nucleoside analogue present in synthetic thermophilic bacterial tRNAs. 2'-O-Methyl-2-thiouridine is more selective for A th...
GS-443902
T5539
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
Lysidine
T21052
Lysidine (2-Methyl-2-iMidazoline) is a nucleoside rarely seen outside of tRNA. Lysidine has better translation fidelity.
Dihydro-5-azacytidine acetate
T78565
Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1] [...
Homouridine
T79190
Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM). Moreover, the derivative of ho...
S-Gem
T79198
S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR. Studies indicate that S-Gem exhibits lower cytotoxicity...
ddUTP (lithium), 100mM in H2O
T82597
ddUTP (lithium), at a concentration of 100mM in H20, serves as a nucleotide analog capable of being integrated into DNA, RNA, or other nucleic acids. It is appli...
Ethynylcytidine
TQ0006
Ethynylcytidine is a nucleoside antimetabolite.
Gemcitabine elaidate
T15378
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with ...
Floxuridine
T0964
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
Doxifluridine
T1600
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridi...
Peldesine
T12399
Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferat...
Tegafur
T1378
Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil ...
6-Mercaptopurine
T0010
6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting puri...
2',5-Difluoro-2'-deoxy-1-arabinosyluracil
TNU0187
2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic a...
Isoguanine
T19382
Isoguanine is a purine base that is an isomer of guanine. A building block in organic synthesis.
Orotic acid
T0746
Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
Cytarabine
T1272
Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophag...
Adenosine
T0853
Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
dGTP
T40192
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8...
2'-O-Methyl-2-thiouridine
TNU0130
2'-O-Methyl-2-thiouridine is a purine nucleoside analogue present in synthetic thermophilic bacterial tRNAs. 2'-O-Methyl-2-thiouridine is more selective for A th...
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TargetMol