Hedgehog/Smoothened

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.

Cat. No.	Product name	CAS No.	Purity
T40465	SAG dihydrochloride	2702366-44-5	98%
T40465	SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and co...
T22814	GSA-10	300833-95-8	98%
T22814	Smoothened (Smo) receptor agonist
T1094	Tolnaftate	2398-96-1	98%
T1094	Tolnaftate is a synthetic antifungal agent.
T14965	Ciliobrevin D	1370554-01-0	98%
T14965	Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibit...
T23370	SMANT hydrochloride	1177600-74-6	98%
T23370	SMANT hydrochloride is an antagonist of Smoothened accumulation.
T22089	HPI 1	599150-20-6	98%
T22089	HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5...
T15019L	CUR61414 hydrochloride		98%
T15019L	CUR61414 is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound. CUR...
T3460	HhAntag	496794-70-8	98%
T3460	HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
T15019	CUR61414	334998-36-6	98%
T15019	CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
T6514	Glasdegib	1095173-27-5	98%
T6514	Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
T3070	GANT 61	500579-04-4	98%
T3070	GANT 61 is an inhibitor for Gli1 and Gli2.
T14188	ALLO-2	1357350-60-7	98%
T14188	ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
T2666	Taladegib	1258861-20-9	98%
T2666	Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic ac...
T21325	TAK-441	1186231-83-3	98%
T21325	TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expr...
T1779	SAG	912545-86-9	98%
T1779	SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
T6891	MK-4101	935273-79-3	98%
T6891	MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
T4211	SAG hydrochloride (912545-86-9(free base))	2095432-58-7	98%
T4211	SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
T3156	Ciliobrevin A	302803-72-1	98%
T3156	Ciliobrevin A is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.
T23027	MRT-10	330829-30-6	98%
T23027	Smoothened (Smo) receptor antagonist
T1810	Purmorphamine	483367-10-8	98%
T1810	Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.