DNA Alkylation

DNA alkylation refers to the addition of alkyl groups to specific bases, resulting in alkylation products such as O2‐alkylthymine, O4‐alkylthymine, O6‐methylguanine and O6‐ethylguanine, which cause DNA mutations.

Cat. No.	Product name	CAS No.	Purity
T11440	GNE-8505	1620573-48-9	98%
T11440	GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
T15771	Lobaplatin	135558-11-1	98%
T15771	Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows...
T11056	DLK-IN-1	1620574-24-4	98%
T11056	DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, re...
T19300	Duocarmycin Analog	372954-15-9	98%
T19300	Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T12813L	Seco-Duocarmycin SA	144667-38-9	98%
T12813L	Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T11120	Duocarmycin TM	157922-77-5	98%
T11120	Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T9985	Methyl methanesulfonate	66-27-3	98%
T9985	Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and rep...
T17212	VAL-083	23261-20-3
T17212	VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
T4350	Palifosfamide	31645-39-3	97%
T4350	Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
T1507	Streptozocin	18883-66-4	97.49%
T1507	Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
T17159	Treosulfan	299-75-2	98%
T17159	Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T7539	O6-Benzylguanine	19916-73-5	98%
T7539	O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
T7221	Satraplatin	129580-63-8	98%
T7221	Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against...
T1250	Thio-TEPA	52-24-4	99.07%
T1250	Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T6057	URMC-099	1229582-33-5	99.32%
T6057	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T3707	GNE-3511	1496581-76-0	99.37%
T3707	GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T0975	Chlorambucil	305-03-3	99.58%
T0975	Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, result...
T2495	Lomeguatrib	192441-08-0	99.62%
T2495	Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T6798	Tretazicar	21919-05-1	99.7%
T6798	CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate ...
T0923	Busulfan	55-98-1	99.77%
T0923	Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood,...