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DNA Alkylation

DNA alkylation refers to the addition of alkyl groups to specific bases, resulting in alkylation products such as O2‐alkylthymine, O4‐alkylthymine, O6‐methylguanine and O6‐ethylguanine, which cause DNA mutations.

  • Streptozocin
    T150718883-66-4
    Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. The product is unstable in solution and is recommended to be dispensed now.
    • $30
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  • Duocarmycin TM
    T11120157922-77-5
    Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
    • $158
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  • Phosphoramide mustard
    T3841010159-53-2
    Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.
    • $293
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  • IACS-52825
    T793032640376-72-1In house
    IACS-52825 is a selective and potent dual leucine zipper kinase (DLK) inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model for the study of neurological disorders.
    • $195
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  • URMC-099
    T60571229582-33-5
    URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
    • $52
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  • DN-1289
    T73457 In house
    DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 40 nM for leucine zipper-bearing kinase (LZK).DN-1289 significantly inhibited optic nerve crush (ONC)-induced p-c-Jun in a mouse model.
    • $350
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  • CEP-40125
    T269781456608-94-8In house
    CEP-40125 (RXDX-107) is a DNA alkylating agent used for researching advanced solid tumors.
    • $293 TargetMol
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  • GNE-3511
    T37071496581-76-0
    GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
    • $45
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  • Carmustine
    T3091154-93-8
    Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
    • $40
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  • Treosulfan
    T17159299-75-2
    Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.[2]
    • $34
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  • Thio-TEPA
    T125052-24-4
    Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
    • $31
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  • Lomustine
    T160113010-47-4
    Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
    • $50
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  • Busulfan
    T092355-98-1
    Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription.
    • $45
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  • Lomeguatrib
    T2495192441-08-0
    Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
    • $43
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  • Palifosfamide
    T435031645-39-3
    Palifosfamide (Isophosphamide mustard) lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to 6.75 μM for most cell lines except OS222 (IC50=31.5 μM).
    • $70
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  • Sarmustine
    T2866381965-43-7In house
    Sarmustine (SarCNU) is an alkylating agent with anticancer activity that inhibits the growth of prostate cancer cells via p53-dependent and p53-independent pathways.Sarmustine mediates the selection of P140K methylguanine-DNA-methyltransferase-transduced human CD34(+) cells in vitro.
    • $195
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  • Methyl methanesulfonate
    T998566-27-3
    Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and replication disorders.
    • $29
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  • Satraplatin
    T7221129580-63-8
    Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
    • $100
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  • Altretamine
    T1241645-05-6
    Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.
    • $30
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  • O6-Benzylguanine
    T753919916-73-5
    O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
    • $42
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  • Tretazicar
    T679821919-05-1
    CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.
    • $47
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  • Chlorambucil
    T0975305-03-3
    Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
    • $50
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  • Miriplatin hydrate
    T21297250159-48-9
    Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Miriplatin hydrate is a lipophilic platinum complex that can be easily suspended in Lipiodol and gradually releases active platinum compounds in tumor tissue.
    • $44
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  • VAL-083
    T1721223261-20-3
    VAL-083 is an alkylating agent with antitumor activity that produces N7 methylation on DNA.
    • $48
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  • GNE-8505
    T114401620573-48-9
    GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
    • $920
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  • Seco-Duocarmycin SA
    T12813L144667-38-9
    Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
    • $2,270
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  • DLK-IN-1
    T110561620574-24-4
    DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days of administration, its concentration
    • $523
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  • Duocarmycin Analog
    T19300372954-15-9
    Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
    • $2,120
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  • Lobaplatin
    T15771135558-11-1
    Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a promising antitumour chemotherapeutic agent[1][2]. It is a platinum complex with DNA alkylating activity.
    • $89
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