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DNA Damage/DNA Repair
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DNA
Deoxyribonucleic acid (DNA) is a molecule composed of two polynucleotide chains that coil around each other to form a double helix carrying genetic instructions for the development, functioning, growth and reproduction of all known organisms and many viruses. DNA and ribonucleic acid (RNA) are nucleic acids. Alongside proteins, lipids and complex carbohydrates (polysaccharides), nucleic acids are one of the four major types of macromolecules that are essential for all known forms of life.
- Aristolochic acid BT7031475-80-9Aristolochic acid B (Aristolochic Acid II) is one of the major components of the carcinogenic plant extract aristolochic acid, is known to be mutagenic and to form DNA adducts in vitro and in vivo, Aristolochic acid B shows more carcinogenic risk than aristolochic acid I, and this may be, at least partly, the result of its increased levels in kidney and plasma.
- $72
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- 3,7,4'-TrihydroxyflavoneTN21432034-65-33,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marrow macrophages induced by NF-κB ligand (RANKL) receptor activators.
- $81
SizeQTY - BCL6-IN-3T104872253878-44-1BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.
- $117
SizeQTY
- Carboxy-pyridostatin 2HClT30745L In houseCarboxy-pyridostatin 2HCl has potential antitumor activity with high affinity for DNA at DNA G4s.
- $228
SizeQTY - 4-EthylcatecholT775631124-39-64-Ethylcatechol is present in red wine and can be extracted from Glechoma longituba (NaKai) Kupr.4-Ethylcatechol induces DNA damage in the presence of Cu(II).4-Ethylcatechol is a potent antiplatelet compound.
- $40
SizeQTY - Tallimustine HClT68151L118438-45-2In houseTallimustine HCl is a DNA inhibitor, an AT-specific alkylated antitumor derivative of diamycin.Tallimustine HCl can be used in severe combined immunodeficiency mouse models of adult myelogenous leukemia, which can be used for the treatment of leukemia.
- $195
SizeQTY - XR 5944T35187343247-32-5XR 5944 is an antitumor compound that targets DNA, is a topoisomerase inhibitor, inhibits ER activity, and can be used to study colon and lung cancer.
- $293
SizeQTY - BTB09089T67892245728-44-3In houseBTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8 GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages.
- $65
SizeQTY - L82T60753329227-30-7In houseL82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
- $64
SizeQTY - ClofazimineT03772030-63-9Clofazimine (NSC-141046) is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.
- $50
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Cited - Cyclophosphamide hydrateT07076055-19-2Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
- $33
SizeQTY Cited - Hydroxychloroquine sulfateT0951747-36-4Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa.
- $48
SizeQTY Cited - Chromium picolinateT457514639-25-9Chromium picolinate causes DNA damage and mutation. It is an activator of p38.
- $41
SizeQTY Cited - CyclophosphamideT0707L50-18-0Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
- $35
SizeQTY Cited - RU.521T54862262452-06-0RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
- $41
SizeQTY Cited - Crystal VioletT1343L548-62-9Crystal Violet (Hexamethylpararosaniline chloride) is a triarylmethane dye that is a mixture of violet rosanilinis, with antibacterial, antifungal, and anthelmintic properties.
- $46
SizeQTY Cited - Quinacrine dihydrochlorideT094269-05-6Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
- $41
SizeQTY Cited - AGI-24512T141412201066-53-5AGI-24512 is a potent inhibitor of methionine adenylyltransferase 2α (MAT2A) (IC50: 8 nM).AGI-24512 shows antiproliferative activity in MTAP-deficient cancer cells.AGI-24512 inhibits MAT2A, which causes DNA damage in MTAP, and is often used in conjunction with anticancer compounds in cancer research.
- $132
SizeQTY - Gemcitabine monophosphate sodium salt hydrateT41871638288-31-9Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
- $198
SizeQTY - NorharmaneT4024244-63-3Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
- $30
SizeQTY - Proflavine HemisulfateT04381811-28-5Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and antiseptic purposes.
- $33
SizeQTY - L67T3103325970-71-6L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).
- $43
SizeQTY - G150T113442369751-30-2G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).
- $135
SizeQTY - L189T451764232-83-3L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
- $36
SizeQTY - MethoxsalenT1548298-81-7Methoxsalen (NCI-C55903) is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.
- $29
SizeQTY - Dibenz[a,h]anthraceneT3142553-70-3Dibenz[a,h]anthracene (CCRIS 208) has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell cultures.
- $50
SizeQTY - Pterine-6-carboxylic acidTN6988948-60-7Pterine-6-carboxylic acid (6-Carboxypterin) is a photodegradation product of folic acid, which can be used as a photosensitive agent to study the molecular mechanism of UVA breaking DNA structure.
- $117
SizeQTY - AzoxymethaneT7371925843-45-2Azoxymethane (AOM) is a DNA damaging agent that induces cancer and can be used in mouse models of colorectal cancer.
- $126
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