tph

p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1].

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].

TPh A (Triphenyl Compound A) is an inhibitor of the nuclear protein pirin (Ki: 0.6 uM), a protein that can be used as a bioprobe to regulate pirin-related functions.

TPH1-IN-1 (compound 40) is a xanthine derivative and inhibitor of tryptophan hydroxylase TPH1, with an IC50 of 110.1 nM. It demonstrates robust in vitro activity and liver microsome stability, effectively impeding the adipocyte differentiation of T3-L1 cells [1].

Xantphos, a ligand in the coupling reaction of Buchwald, Suzuki and others, is a metal chelating ligand that can be used to catalyze the reaction.

[(2-Di-tert-butylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)-2-(2'-amino-1,1'-biphenyl)]palladium(II) methanesulfonate is a useful organic compound for research related to life sciences. The catalog number is T64584 and the CAS number is 1536473-72-9.

(tBuBrettPhos Pd(allyl))TfOH salt is a useful organic compound for research related to life sciences and the catalog number is T64621.

BrettPhos Pd G4 is a useful organic compound for research related to life sciences. The catalog number is T64764 and the CAS number is 1599466-83-7.

Methanesulfonato[4,6-bis(diphenylphosphino)phenoxazine](2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67254.

AdBrettPhos Pd G3 is a useful organic compound for research related to life sciences and the catalog number is T67255.

Methanesulfonato[9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene](2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67260.

Triphenyl-D15-tin-chloride (TPhTCl) (Standard) is a reference standard of Triphenyl-D15-tin-chloride (TPhTCl) intended for quantitative analysis, quality control, and related biochemical research applications.

MOP-dTphosphoramidite is MOP-dT monomer, used for oligonucleotide synthesis research.

N-Xantphos is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Pd(Xantphos)Cl2 is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

MPTP hydrochloride is a dopamine neurotoxin and the precursor of MPP⁺. It can induce apoptosis and has the ability to cross the blood-brain barrier. MPTP hydrochloride is toxic to dopaminergic neurons and is commonly used for the construction of Parkinson's disease animal models.

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a selective, effective, and reversible tryptophan hydroxylase (TPH) inhibitor, exhibits competitive inhibition with a Ki of 32.6 μM.

Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.

Cobalt phthalocyanine (Phthalocyanine cobalt complex) is a catalyst for a redox reaction.

Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential antiserotonergic activity.

(S)-GNA-T-phosphoramidite is a nucleoside analog commonly used in the synthesis of other active compounds.

Rodatristat ethyl (KAR5585) is a groundbreaking, orally active, and potent inhibitor of tryptophan hydroxylase 1 (TPH1) that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hypertension (PAH) at low concentrations.

Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).

ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.