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By Tag- C-6xHis
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By Tag By Expression System- E. coli(4)
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Results for "
smad 3
" in TargetMol Product Catalog- Inhibitors & Agonists8
- Natural Products3
- Recombinant Protein6
CompareSMAD3, SMAD family member 3, SMAD 3, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, MADH3, Mad3, MAD homolog 3, JV15-2, hSMAD3, hMAD-3
TMPJ-00271
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3 SMAD4 complex, activates transcription. It also can form a SMAD3 SMAD4 JUN FOS complex at the AP-1 SMAD site to regulate TGF-beta-mediated transcription. SMAD3 has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive.
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CompareSMAD3, SMAD family member 3 (SMAD 3;Smad3;hSMAD3), Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, MADH3, Mad3, MAD homolog 3, JV15-2, hMAD-3
TMPH-01700
Expression system: Baculovirus Insect Cells
Length: 1-425, Full Length
Activity: Not Tested
Length: 1-425, Full Length
Activity: Not Tested
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Buffer-exchangeable
CompareOsteogenin, Bone morphogenetic protein 3A (BMP-3A), Bone morphogenetic protein 3, BMP3A, BMP-3, BMP3
TMPH-01015
Expression system: E. coli
Length: 363-472, Full Length of Mature Protein
Activity: Not Tested
Length: 363-472, Full Length of Mature Protein
Activity: Not Tested
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Buffer-exchangeable
CompareSMAD2, SMAD family member 2 (SMAD 2;Smad2;hSMAD2), Mothers against DPP homolog 2, Mothers against decapentaplegic homolog 2, Mad-related protein 2 (hMAD-2), MADR2, MADH2, MAD homolog 2, JV18-1
TMPH-01699
Expression system: E. coli
Length: 2-467, Full Length of Mature Protein
Activity: Not Tested
Length: 2-467, Full Length of Mature Protein
Activity: Not Tested
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Buffer-exchangeable
CompareSMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4
TMPJ-01108
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2 SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2 SMAD4 FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumor suppressor. It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
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CompareSMAD family member 3
TMPY-03419
Expression system: Baculovirus Insect Cells
Length: 1-425, Full Length
Activity: Not Tested
Length: 1-425, Full Length
Activity: Not Tested
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