oligonucleotide

2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.

CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.

UNC10217938A HCl (UNC7938 HCl) is a 3-deazapteridine analog. UNC10217938A HCl exhibits strong oligonucleotide enhancing effects. UNC10217938A HCl can modulate their intracellular trafficking and release from endosomes, leading to enhance oligonucleotides effects. UNC10217938A HCl also enhances the effects of siRNA and antisense oligonucleotides.

Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Paromomycin Sulfate (Aminosidine sulfate) is the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria.

Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.

5'-O-DMT-N2-ibu-dG is a deoxynucleoside used in the preparation of oligonucleotides, served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions during synthesis.

5-Methoxysalicylic acid (5-MeOSA), a natural product, serves as an effective matrix for oligonucleotide analysis in MALDI MS when used alongside spermine.

UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects.

DMTr-LNA-5MeU-3-CED-phosphoramidite, a nucleoside derivative, is a modified building block used in oligonucleotide synthesis to enhance stability and binding affinity.

Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].

Schizophyllan is an extracellular β-glucan synthesized by Schizophyllum commune. It improves mitochondrial function by activating the SIRT3 signaling pathway, thereby alleviating metabolic liver injury. Meanwhile, it inhibits JNK/p38 phosphorylation and downregulates the expression of PGC1β/PPARγ, c-Fos and NFATc1, thus suppressing osteoclast formation and promoting osteoblast differentiation. In addition, Schizophyllan enables targeted delivery of oligonucleotide drugs and antigens to antigen-presenting cells via Dectin-1-mediated recognition, showing broad application prospects in the treatment of inflammatory diseases and vaccine development.

Perylene dU phosphoramidite is a bright and extremely photostable fluorescent polycyclic aromatic hydrocarbon (PAH) label with a nearly quantitative quantum yield. This phosphoramidite enables the incorporation of perylene into DNA through automated oligonucleotide synthesis.

5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.

LCL-PEG3-N3 is a bait oligonucleotide E3 ligase ligand used for developing chimeric molecules like LCL-ER(dec) to degrade estrogen receptors. As a click chemistry reagent, it includes an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that possess DBCO or BCN groups.

LCL-PEG3-N3 (hydrochloride) serves as a bait oligonucleotide E3 ligase ligand, useful for developing chimeric molecules like LCL-ER(dec) to degrade estrogen receptors. As a click chemistry reagent featuring an Azide group, it can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

ssRNA41 sodium is a 20-mer phosphorothioate-protected single-stranded RNA oligonucleotide derived from ssRNA40 by replacing all uracil (U) bases with adenine (A). It does not induce type-I IFN production and serves as a negative control for ssRNA40.

Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl–modified antisense oligonucleotide that selectively targets transthyretin RNA, reduces TTR transcript and protein levels. Inotersen serves as a validated molecular tool for mechanistic and translational research into hereditary transthyretin amyloidosis polyneuropathy.

Donidalorsen is an antisense oligonucleotide engineered to selectively reduce the production of prekallikrein (PKK), a key upstream mediator in inflammatory cascade activation, and is used in hereditary angioedema research to investigate bradykinin-driven inflammation, acute attack prevention mechanisms, and RNA-targeted therapeutic strategies.

Decamethylene glycol is a substance used as a reagent in the biological study of modified oligonucleotide with in vivo antitumoral activity. Also used in the pharmaceutical study on the composition of essential oils obtained from myrrh and frankincense an

Basivarsen linker is a connector employed in Zeleciment basivarsen, facilitating the attachment of a Fab antibody (Zeleciment) that targets the TfR1 receptor to an antisense oligonucleotide. Zeleciment basivarsen is studied for its potential application in the treatment of myotonic dystrophy type 1 (DM1).

Zeleciment basivarsen (DYNE-101) is an antibody oligonucleotide conjugate (AOC), consisting of a Fab antibody named Zeleciment that binds to the transferrin receptor 1 (TfR1) on muscle cells, and an antisense oligonucleotide known as Basivarsen. This compound targets the RNA of the mutant dystrophia myotonica-protein kinase (DMPK) for RNase H-mediated degradation, and is utilized in the study of myotonic dystrophy type 1 (DM1).

Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin, an anti-apoptotic protein. Clusterin expression is upregulated in response to chemotherapy and contributes to drug resistance.

ODN TTAGGG sodium, an inhibitory oligonucleotide (ODN), is an antagonist of TLR9, AIM2, and cGAS. It exerts immunosuppressive effects by inhibiting AIM2 inflammasome activation and cGAS activation through competitive interaction with DNA. This compound can be utilized in research on autoimmune diseases such as lupus. The sequence for ODN TTAGGG is 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.

Danvantisen sodium is an antisense oligonucleotide targeting STAT3 with potential antineoplastic properties. It binds to STAT3 mRNA, thereby inhibiting the translation of the transcript. Suppressing STAT3 expression can lead to the induction of tumor cell apoptosis and inhibition of tumor cell growth.