oligonucleotide

2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.

CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.

UNC10217938A HCl (UNC7938 HCl) is a 3-deazapteridine analog. UNC10217938A HCl exhibits strong oligonucleotide enhancing effects. UNC10217938A HCl can modulate their intracellular trafficking and release from endosomes, leading to enhance oligonucleotides effects. UNC10217938A HCl also enhances the effects of siRNA and antisense oligonucleotides.

Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Paromomycin Sulfate (Aminosidine sulfate) is the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria.

Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets and serves as an intermediate in the synthesis of 5'-DMT-3'-phosphoramidite, an antisense compound resistant to nuclease.

5'-O-DMT-N2-ibu-dG is a deoxynucleoside used in the preparation of oligonucleotides, served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions during synthesis.

5-Methoxysalicylic acid (5-MeOSA), a natural product, serves as an effective matrix for oligonucleotide analysis in MALDI MS when used alongside spermine.

UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects.

DMTr-LNA-5MeU-3-CED-phosphoramidite, a nucleoside derivative, is a modified building block used in oligonucleotide synthesis to enhance stability and binding affinity.

Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].

5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.

LCL-PEG3-N3 is a bait oligonucleotide E3 ligase ligand used for developing chimeric molecules like LCL-ER(dec) to degrade estrogen receptors. As a click chemistry reagent, it includes an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that possess DBCO or BCN groups.

LCL-PEG3-N3 (hydrochloride) serves as a bait oligonucleotide E3 ligase ligand, useful for developing chimeric molecules like LCL-ER(dec) to degrade estrogen receptors. As a click chemistry reagent featuring an Azide group, it can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

ssRNA41 sodium is a 20-mer phosphorothioate-protected single-stranded RNA oligonucleotide derived from ssRNA40 by replacing all uracil (U) bases with adenine (A). It does not induce type-I IFN production and serves as a negative control for ssRNA40.

Decamethylene glycol is a substance used as a reagent in the biological study of modified oligonucleotide with in vivo antitumoral activity. Also used in the pharmaceutical study on the composition of essential oils obtained from myrrh and frankincense an

DMT-dC(ac) Phosphoramidite is a modified phosphoramidite monomer designed for oligonucleotide synthesis.

DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer used in oligonucleotide synthesis.

2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer utilized in oligonucleotide synthesis.

2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer used in oligonucleotide synthesis.

2'-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer suitable for oligonucleotide synthesis.

5'-O-DMT-2'-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.

5'-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1]. [1]. Schulhof JC, et, al. The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups. Nucleic Acids Res. 1987 Jan 26;15(2):397-416.

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine, an adenosine derivative, functions as an intermediate in oligonucleotide synthesis.

Ac-dA Phosphoramidite is a phosphinamide monomer utilized in oligonucleotide synthesis.