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Results for "

lncap

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    94
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • PROTAC Products
    11
    TargetMol | PROTAC
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    19
    TargetMol | Natural_Products
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    2
    TargetMol | Isotope_Products
Enzalutamide
MDV3100
T6002915087-33-1
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP) that activates autophagy, exhibits antitumor activity, and is commonly used in treating desmoplasia-resistant prostate cancer.
  • $40
In Stock
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QTY
TargetMol | Inhibitor Hot
Abacavir sulfate
Ziagen, ABC sulfate, Abacavir Hemisulfate, 1592U89
T6367188062-50-2
Abacavir sulfate (Ziagen) , a nucleoside analogue, effectively utilize its antiviral activity
  • $39
In Stock
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QTY
AR antagonist 1
T103591818885-54-9
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
  • $78
In Stock
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TargetMol | Inhibitor Sale
HPOB
T24301429651-50-2
HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
  • $50
In Stock
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TargetMol | Inhibitor Sale
vipivotide tetraxetan
PSMA-617
T125731702967-37-0
Vipivotide tetraxetan (PSMA-617) is a highly potent inhibitor of prostate-specific membrane antigen (PSMA) with a Ki of 0.37 nM.
  • $193
In Stock
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TargetMol | Inhibitor Hot
Fulvestrant
ZM 182780, ZD 9238, ICI 182780
T2146129453-61-8
Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell proliferation and inducing apoptosis and autophagy.
  • $42
In Stock
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TargetMol | Inhibitor Hot
Androgen receptor antagonist 1
T103201338812-36-4In house
Androgen receptor antagonist 1, an orally available full androgen receptor antagonist (IC50: 59 nM), is utilized in the synthesis of PROTAC AR degraders, achieving 24% and 47% AR protein degradation in LNCaP cells at concentrations of 1 μM and 10 μM, respectively.
  • $1,520
6-8 weeks
Size
QTY
ONC1-13B
ONC-1-13B, ONC-113B, ONC 113B, ONC 1 13B
T282381351185-54-0In house
ONC1-13B is a potent androgen receptor (AR) antagonist with an ic50 in the range of 59-80 nM that inhibits PSA production in androgen-sensitive human PCa LNCaP cells.
  • $293 TargetMol
In Stock
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VPC-13163
VPC13163, VPC 13163, NSC52361, NSC 52361, 2,3-dihydro-2,3'-Bi-1H-indole
T291106637-10-1In house
VPC-13163 (NSC-52361) has strong anti-proliferative activity against LNCaP and Enzalutamide-resistant prostate cancer cell lines (MR49F) whereas it did not affect the growth of AR independent PC3 cell line. It also inhibits Prostate Specific Antigen (PSA) in both LNCaP and MR49F and reduces expression of AR target genes, PSA and TMPRSS2. These findings suggest that VPC-13566 exhibits AR BF3 specific mechanism of action.
  • $82
In Stock
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ABBV-744
ABBV744
T46972138861-99-9In house
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2 3 4. It is used in the research on inflammatory diseases, cancer, and AIDS.
  • $39
In Stock
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mTOR inhibitor 9d
T677021144075-38-6In house
mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia, skin cancer, breast cancer, lung cancer and colon cancer.
  • $210
In Stock
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mTOR inhibitor 9a
T677051144075-32-0In house
mTOR inhibitor 9a inhibited the growth of human LNCap cells with an ic50 of 80 nm. 1-methyl-3 -{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea may have antitumor activity.
  • $210
In Stock
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TargetMol | Inhibitor Sale
TRIM24/BRPF1-IN-2
T742713033288-68-2In house
TRIM24 BRPF1-IN-2 is a selective dual TRIM24 BRPF1 inhibitor with anticancer activity that inhibits proliferation, gene and protein expression, and colony formation of prostate cancer cells in a dose-dependent manner.
  • $335
In Stock
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Bexlosteride
T9660148905-78-6In house
Bexlosteride (LY300502), a benzoquinolinone derivative, functions as a human type I 5α-reductase inhibitor. It demonstrates metabolic inhibition, antiproliferative, and antisecretory activities specifically in LNCaP human prostatic adenocarcinoma cell cultures, positioning it as a potent agent for prostate cancer research [1] [2].
  • $2,140
3-6 months
Size
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Venuloside A
ESK246
TN72561609278-97-8In house
Venuloside A (ESK246), a monoprostane glycoside from Pittosporum venulosum, is a LAT3 inhibitor and a leucine uptake inhibitor that inhibits the transporter of leucine through LAT3, and may be used in the study of prostate cancer.
  • $195 TargetMol
In Stock
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Docetaxel
RP-56976, NSC 628503
T1034114977-28-5
Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 μM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity.
  • $30
In Stock
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Mifepristone
RU486, RU 38486, C-1073
T110284371-65-3
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
  • $37
In Stock
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Adavosertib
MK-1775, AZD1775, Adavosertib (MK-1775)
T2077955365-80-7
Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.
  • $40
In Stock
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Amygdalin
Laetrile
T279529883-15-6
Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induced by IL-1beta and better than the single use of Amygdalin or HSYA. Amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax.
  • $42
In Stock
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4-Isopropoxybenzaldehyde
ALDH1A3-IN-3
T6434718962-05-5
4-Isopropoxybenzaldehyde (compound 16), a powerful ALDH1A3 inhibitor with an IC50 of 0.26 μM (cell free assay), serves as an effective ALDH3A1 substrate. But shows weak antiproliferative effect against PC3, LNCaP, and DU145 PCa cell lines with IC50>200 μM[1].
  • $29
In Stock
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C75
C-75
T10657218137-86-1
C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).C75 increases CPT1 activity and reduces DIO.
  • $41
In Stock
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EZM 2302
GSK3359088
T56051628830-21-6
EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).[1]
  • $68
In Stock
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Calcitriol
Topitriol, Rocaltrol, RO215535, Calcijex, 1,25-Dihydroxyvitamin D3
T631632222-06-3
Calcitriol (1,25-Dihydroxyvitamin D3) is a metabolite of vitamin D and a vitamin D receptor (VDR) agonist (IC50=0.4 nM). Calcitriol increases intestinal absorption of calcium and phosphorus, and increases bone resorption with parathyroid hormone.
  • $66
In Stock
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NSC348884
T690981624-55-7
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.
  • $35
In Stock
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TargetMol | Inhibitor Sale