ketone

Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.

Z-AEVD-FMK (Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone) is a degradable ADC linker and caspase-10 inhibitor, reducing TNF-α/butyrate-induced apoptosis, and inhibiting Gal-9-induced apoptosis.

D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) diTFA effectively inhibits fibrinolytic enzyme activity.

Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) acts as a cysteine protease inhibitor and has demonstrated efficacy in blocking SARS infection, while also providing protection to mice when challenged with T. crassiceps [1] [2].

Ala-Ala-Pro-Val-chloromethylketone serves as an irreversible inhibitor of human neutrophil elastase (NE), utilized in researching chronic inflammatory airway diseases.

Val-Arg-Pro-DL-Arg-Fluoromethylketone, a potent MALT1 inhibitor, exhibits anticancer activity by inhibiting cell proliferation and migration [1].

Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically targets serine/threonine proteases and has been shown to inhibit activated porcine factor IX [1].

D-Pro-Phe-Arg-Chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, is significant in the regulation of thrombosis and inflammation [1].

Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].

Z-Phe-Ala-diazomethylketone directly binds to Aβ42 monomers and small oligomers, inhibiting Aβ42 dodecamer formation and preventing Aβ42 fibrillogenesis in solution. This compound holds potential for research into neurodegenerative disorders [1].

Z-Phe-Phe-Diazomethylketone is a selective inhibitor of cathepsin L [1].

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that irreversibly binds to activated caspase-3 in apoptotic cells, with fluorescence intensity measurable via flow cytometry, microwell plate reader, or fluorescence microscopy [1].

D-Val-Leu-Lys-chloromethylketone, a tripeptide, functions as an anticoagulant [1].

Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.

Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.

Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) is a potent and selective inhibitor of gingipain-K, effectively extending plasma thrombin time (TT) in proportion to dosage and duration [1].

Decanoyl-Arg-Val-Arg-Lys-chloromethylketone (DEC-RVRK-CMK) is a small, synthetic, irreversible cell-permeable competitive inhibitor of furin that exhibits strong antiviral activity against Zika virus (ZIKV) and Japanese encephalitis virus (JEV) [1].

3-Hydroxybutyrate dehydrogenase (3-HBDH), a mitochondrial enzyme, plays a crucial role in the metabolism of ketone bodies and butanoate, catalyzing the conversion of (R)-3-hydroxybutanoate into acetoacetate [1]. This enzyme is frequently utilized in biochemical studies due to its involvement in both the synthesis and degradation of key metabolic substances.

Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), inhibits Cathepsin B (Cat-B) and Cathepsin L (Cat-L) and is used in cancer aggressiveness research [1] [2].