Search Result

Search Results for " dyslipidemia "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9766	GW590735		PPAR
	GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used in dyslipidemia studies.		PPAR
T4628	Seladelpar	MBX 8025	PPAR
	Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.		PPAR
T27719	KD-026	SLx 4090,SLx4090,KD026,SLx-4090	CETP
	KD-026 (SLx 4090), a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.		CETP
T20950	MK-8245 analog	MK-8245-analog,MK 8245 analog	Others
	MK-8245 analog is an analog of MK-8245 which is a liver-targeted Inhibitor of Stearoyl-CoA Desaturase (SCD). It is useful for the Treatment of Dyslipidemia and Diabetes.		Others
T77784	WAY-297848		Glucokinase
	WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.		Glucokinase
T27439	GS-9667	CVT-3619,CVT 3619	Adenosine Receptor
	GS-9667, a selective and partial agonist of the A(1) adenosine receptor (AR), represents an effective therapy for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA).		Adenosine Receptor
T27509	GW-493838	GW 493838X,GW 493838,GW493838,GW493838X,GW-493838X	Adenosine Receptor
	GW-493838 is a potent adenosine A1A receptor agonist for the treatment of dyslipidemia and neuropathic pain, with analgesic effects on post-herpetic neuralgia or peripheral nerve damage caused by trauma or surgery.		Adenosine Receptor
T21587	Muraglitazar	Pargluva,BMS-298585	PPAR
	Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r...		PPAR
T38683	SCD1 inhibitor-3	SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a	Dehydrogenase
	SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety. SCD1 inhibitor-3 demonstrates strong potential for research in metabolic diseases, including obesit...		Dehydrogenase
T3685	SR9009	Stenabolic,REV-ERB Agonist II	Autophagy
	SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during...		Autophagy
T27706	K-111	BM170744,BM 170744,BM-170744,K111
	K-111 is a PPAR alpha agonist. K-111 improves insulin resistance, reducing bodyweight, and ameliorating atherogenic dyslipidemia.
T27749	KRP-297	KRP297,MK-0767,L410198,L 410198
	KRP297 is a PPAR agonist potentially for the treatment of type 2 diabetes and dyslipidemia.
T33415	MK 0767	MK0767,MK-0767
	MK 0767 is a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist that has been investigated as a potential treatment for type 2 diabetes and dyslipidemia.
T31083	CP-868388 free base	CP868388,CP 868388,(-)-CP-868388,UNII-999KY5ZIGB,CP-868388	PPAR
	CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.		PPAR
T15264	Exicorilant	CORT 125281	Others
	Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.		Others
T71560	Atorvastatin magnesium trihydrate
	Atorvastatin magnesium trihydrate is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase...
T71492	Atorvastatin strontium
	Atorvastatin strontium is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme...
T80817	WAY-328127
	WAY-328127 is an active molecule, exhibiting an inhibitory effect on the (11β-hydroxysteroid dehydrogenase type 1) [(11β-HSD1)] enzyme. This modulation potentially leads to therapeutic applications in metabolic disorders...
T60535	PPARα/γ agonist 1
	PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes. PPARα/γ agonist 1 has EC50 values of 28 nM and 69 nM for PPARα and PPARγ, respe...
T62220	DGAT1-IN-3
	DGAT1-IN-3 is a selective, potent, orally active DGAT-1 inhibitor that inhibits human DGAT-1 (IC50: 38 nM) and rat DGAT-1 (IC50: 120 nM).DGAT1-IN-3 can be used in studies of obesity, dyslipidemia and metabolic syndrome.
T63876	TRβ agonist 1
	TRβ Agonist 1, a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, demonstrates an EC50 value of 21 nM. It is useful in the research of dyslipidemia, nonalcoholic steatohepatitis (NASH), and resi...
T79051	PCSK9-IN-15
	PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, K D <200 nM) that plays a crucial role in cholesterol metabolism by regulating blood levels of low-density lipoprotein ch...
T10964L	DB1976 dihydrochloride	DB1976 hydrochloride,DB1976 2HCl	Apoptosis , NF-κB
	DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and improved glucose homeostasis and dyslipidemia in mice in i...		Apoptosis , NF-κB
T37522	Teneligliptin
	Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. Teneli...

Compounds

Synonym: SLx 4090,SLx4090,KD026,SLx-4090

Target: CETP

MK-8245 analog

T20950

Synonym: MK-8245-analog,MK 8245 analog

Synonym: CVT-3619,CVT 3619

Target: Adenosine Receptor

GW-493838

T27509

Synonym: GW 493838X,GW 493838,GW493838,GW493838X,GW-493838X

Target: Adenosine Receptor

Muraglitazar

T21587

Synonym: Pargluva,BMS-298585

Target: PPAR

SCD1 inhibitor-3

T38683

Synonym: SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a

Target: Dehydrogenase

SR9009

T3685

Synonym: Stenabolic,REV-ERB Agonist II

Target: Autophagy

K-111

T27706

Synonym: BM170744,BM 170744,BM-170744,K111

Target:

KRP-297

T27749

Synonym: KRP297,MK-0767,L410198,L 410198

Target:

MK 0767

T33415

Synonym: MK0767,MK-0767

Target:

CP-868388 free base

T31083

Synonym: CP868388,CP 868388,(-)-CP-868388,UNII-999KY5ZIGB,CP-868388

Atorvastatin magnesium trihydrate

T71560

Synonym:

Target:

Atorvastatin strontium

DB1976 dihydrochloride

T10964L

Synonym: DB1976 hydrochloride,DB1976 2HCl

Target: Apoptosis, NF-κB

Cat No.	Product Name	Synonyms	Targets
T7992	4-Hydroxyflavanone		NO Synthase
	4-Hydroxyflavanone is a natural product, shows full vasorelaxing effects		NO Synthase
T3324	Lycorine	Galanthidine,Narcissine,Amarylline,Belamarine,Licorine	Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase
	Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T5S2178	Fargesin	(+/-)-Fargesin	Adrenergic Receptor
	1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating...		Adrenergic Receptor
T73074	Phanginin A
	Phanginin A, a potent and orally active activator of salt-induced kinase 1 (SIK1), effectively inhibits gluconeogenesis, increases the expression of p-SIK1, and decreases the expression of p-CREB. By reducing blood gluco...

Natural Products

Synonym: Galanthidine,Narcissine,Amarylline,Belamarine,Licorine

Target: Apoptosis, Virus Protease, Antibacterial, AChR, Fatty Acid Synthase

Fargesin

T5S2178

Synonym: (+/-)-Fargesin

Target: Adrenergic Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02103	FABP4 Protein, Human, Recombinant (29 Ala/Thr, His)	Human	E. coli
	Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to thecalyc...
TMPY-01482	FABP4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to thecalyc...
TMPY-04004	Angiopoietin-like 7 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...
TMPY-04001	Angiopoietin-like 7 Protein, Canine, Recombinant (His)	Canine	HEK293
	ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...
TMPY-04000	Angiopoietin-like 7 Protein, Canine, Recombinant (hFc)	Canine	HEK293
	ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...