Home Tools
Log in
Products Inhibitors Libraries Recombinant Proteins Kits Services Contact Us
Cart
Peptides Monoclonal Antibodies Dye Reagents PROTAC Virtual Screening TargetMol Kits Cell Counting Kit-8 (CCK-8) Inhibitor Cocktails Natural Products Phenols Alkaloids Flavonoids
Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library
TargetMol
Cytokines and Growth Factors •   Cytokines •   Growth Factors Receptor Proteins •   Fc Receptors •   Cytokines and Growth Factor Receptors
CD Proteins •   T Cell CD Proteins •   B Cell CD Proteins Immune Checkpoint Proteins •   Co-inhibitory Immune Checkpoint Proteins •   Co-stimulatory Immune Checkpoint Proteins
CAR-T Therapy Target Proteins •   Hematologic Malignancies Target Proteins •   Solid Tumors Target Proteins Enzymes •   Oxidoreductases,EC 1 •   Transferases,EC 2
Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

Search Result

Search Results for " dihydrofolate "

Targets

Others

62

Compounds

3

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T3693 DHFR-IN-3 7-bromoquinazoline-2,4-diamine Others
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.
T6120 Pralatrexate Folotyn,10-Propargyl-10-deazaaminopterin Apoptosis , DHFR , Antifolate , TAM Receptor
Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act...
T20340 10-Formyldihydrofolate
10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase.
T29460 5-Methyldihydrofolate
5-Methyldihydrofolate is the primary biologically active form of folate used for DNA reproduction, the cysteine cycle, and the regulation of homocysteine.
T17257L WR99210 hydrochloride(47326-86-3 free base) WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine Others
WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mut...
T24962 10-Formylfolic acid DHFR
10-Formylfolic acid is a novel and potent inhibitor of dihydrofolate reductase, which can be used in leukemia research.
T19858 Brodimoprim DHFR , Antibacterial
Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile.
T0849 Pyrimethamine Pirimecidan,RP 4753,Pirimetamin DHFR , Antifolate , Parasite
Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
TQ0113 Iclaprim AR-100 Antibacterial , Antibiotic
Iclaprim (AR-100) is a novel specific bacterial Dihydrofolate inhibitor. It can inhibit the growth of S. aureus (MIC90: 0.06 μg/mL).
T25886 Methotrexate Diglutamate NSC-269401,NSC 269401,NSC269401 DHFR
Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.
T61486 DHFR-IN-4 DHFR
DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.
T24644 Piritrexim BW 301U DHFR
Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinoma and metastatic breast cancer.
T5420 Cycloguanil hydrochloride Chloroguanide Triazine Parasite , Drug Metabolite
Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, r...
T1485 Methotrexate NCI-C04671,WR19039,Amethopterin,CL14377 Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v...
T4382 Proguanil hydrochloride Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil Others , Dehydrogenase , DNA/RNA Synthesis , Antifolate , Parasite
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ...
T36692 Fanotaprim DHFR
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o...
T64295 Talotrexin ammonium DHFR
Talotrexin ammonium is a non-polyglutamic acid antifolate. Talotrexin ammonium inhibits tumor growth by targeting dihydrofolate reductase (DHFR), thereby improving anti-tumor activity in a wide range of cancer models, he...
T20339 7-Hydroxymethotrexate NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962 Drug Metabolite
7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibitin...
T30761 CB 3703 CB3703,NSC 289522,CB-3703
CB 3703 is an inhibitor of dihydrofolate reductase and thymidylate synthase.
T17164 Trimetrexate CI-898 Others
Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.
T27002 CH-1504 CH 1504,MobileTrex
CH-1504, dihydrofolate reductase (DHFR) inhibitor, is used potentially for the treatment of rheumatoid arthritis.
T69591 Cycloguanil nitrate
Cycloguanil nitrate is a dihydrofolate reductase inhibitor and is a metabolite of the antimalarial drug proguanil.
T23883 Chlorasquin Ccnsc-529,861,Ccnsc 529,861,SK 29861,Ccnsc529,861,SK-29861
Chlorasquin is a dihydrofolate reductase inhibitor.
T24459 Metioprim Ro126995,Ro 126995,He 909,He909,Ro 12-6995
Metioprim is a competitive bacterial dihydrofolate reductases inhibitor.
T25381 Epiroprim Epiroprime,Ro11-8958,Ro 11-8958,Ro-11-8958
Epiroprim is an analog of trimethoprim and a dihydrofolate reductase inhibitor.
T24427 Lysine-methotrexate ADMPL
Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase.
T10915 Cycloguanil D6 Nitrate Chlorguanide triazine D6 Nitrate Others
Cycloguanil D6 Nitrate is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil.
T7730L Aminopterin sodium NSC739,NSC 739 [as the base],NSC-739
Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affini...
T70080 Methasquin
Methasquin is a folic acid antagonist that has been used in the treatment of experimental leukemia; acts by inhibiting the dihydrofolate reductase in the cell.
T29003 TRC-19
TRC-19 is a potent and selective inhibitor of Toxoplasma gondii dihydrofolate reductase. TRC-19 shows an IC50 of 9 nM and 89-fold selectivity in favor of Toxoplasma gondii dihydrofolate reductase.
T24571 Ornithine-methotrexate ADMPO
Ornithine-methotrexate is a ornithine analog of methotrexate. It is an inhibitors of dihydrofolate reductase.
T25079 Aminopterin N-hydroxysuccinimide ester Nhs-aminopterin,N-Hydroxysuccinimide aminopterin
Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase...
T25332 Dihydrohomofolic acid
Dihydrohomofolic acid is a substrate for dihydrofolate reductase that produces tetrahydro-homo folate which in turn suppresses thymidylate synthetase and then DNA synthesis.
T12742 Ro 20-0657/000 Others
Ro 20-0657/000 is a Trimethoprim metabolite. Trimethoprim is an inhibitor of dihydrofolate reductase, used as an antibacterial agent in human and veterinary medicine.
T10916 Cycloguanil D6 Chlorguanide triazine D6 Others
Cycloguanil D6 is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil.
T22409 Proguanil chloroguanide,chlorguanide Others
Proguanil, a prophylactic antimalarial drug, inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of pyrimidines and purines, which are essential for DNA synthesis and cell multiplication...
T25324 Dichloromethotrexate NSC 29630,3988-B-129-4,NSC29630,Dichloroamethopterin,NSC-29630
Dichloromethotrexate is an enzyme dihydrofolate reductase inhibitor, thus preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by th...
T79912 NSC309401
NSC309401 is an E. coli dihydrofolate reductase inhibitor, displaying potency with an IC50 value of 189 nM and a dissociation constant (KD) of 14.57 nM [1].
T68684 Piritrexim isethionate
Piritrexim isethionate is a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that appears to be an active agent in patients with metastatic urothelial cancer when administered as a 5-day, low-dose oral schedule.
T25981 Pralatrexate, (S)-
Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ...
T25980 Pralatrexate, (R)-
Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ...
T81639 NSC309401 dihydrochloride
NSC309401 is an E. coli dihydrofolate reductase inhibitor with an IC50 value of 189 nM and a dissociation constant (Kd) of 14.57 nM [1].
T25374 Emofolin sodium NSC139490,MeTHHF disodium,NSC-139490,NSC 139490
Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity，which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition o...
T63985 Trimetrexate glucuronate
Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist that inhibits dihydrofolate reductase, which in turn blocks the synthesis of purine nucleotides and thymidylic acid, affecting DNA and RNA synthesis and ex...
T61272 EGFR/HER2-IN-7
EGFR/HER2-IN-7 is a highly selective and potent anticancer compound specifically designed to target MCF-7 breast cancer cells. It functions as a dual inhibitor, targeting both EGFR/HER2 kinases and DHFR (dihydrofolate re...
T39862 Trimethoprim lactate
Trimethoprim lactic is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria . Trimetho...
T69089 Trimethoprim sulfate
Trimethoprim sulfate is a pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is poten...
T82571 DHFR-IN-10
DHFR-IN-10 (compound 4c) is a potent inhibitor of dihydrofolate reductase (DHFR), displaying an inhibition concentration half-maximum (IC50) of 4.21 μM against Mycobacterium tuberculosis DHFR enzyme and demonstrates stro...
T75259 Baquiloprim
Baquiloprim, an antibiotic, functions as a selective inhibitor of bacterial dihydrofolate reductases, exhibiting in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria [1] [2].
T60726 OYYF-175
OYYF-175 is an antimicrobial antifolate. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains. OYYF-175 is an inhibitor of dihydrofolate reductas...

Compounds

DHFR-IN-3
T3693
Synonym: 7-bromoquinazoline-2,4-diamine
Target: Others
Pralatrexate
T6120
Synonym: Folotyn,10-Propargyl-10-deazaaminopterin
Target: Apoptosis, DHFR, Antifolate, TAM Receptor
10-Formyldihydrofolate
T20340
Synonym:
Target:
5-Methyldihydrofolate
T29460
Synonym:
Target:
WR99210 hydrochloride(47326-86-3 free base)
T17257L
Synonym: WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine
Target: Others
10-Formylfolic acid
T24962
Synonym:
Target: DHFR
Brodimoprim
T19858
Synonym:
Target: DHFR, Antibacterial
Pyrimethamine
T0849
Synonym: Pirimecidan,RP 4753,Pirimetamin
Target: DHFR, Antifolate, Parasite
Iclaprim
TQ0113
Synonym: AR-100
Target: Antibacterial, Antibiotic
Methotrexate Diglutamate
T25886
Synonym: NSC-269401,NSC 269401,NSC269401
Target: DHFR
DHFR-IN-4
T61486
Synonym:
Target: DHFR
Piritrexim
T24644
Synonym: BW 301U
Target: DHFR
Cycloguanil hydrochloride
T5420
Synonym: Chloroguanide Triazine
Target: Parasite, Drug Metabolite
Methotrexate
T1485
Synonym: NCI-C04671,WR19039,Amethopterin,CL14377
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
Proguanil hydrochloride
T4382
Synonym: Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil
Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite
Fanotaprim
T36692
Synonym:
Target: DHFR
Talotrexin ammonium
T64295
Synonym:
Target: DHFR
7-Hydroxymethotrexate
T20339
Synonym: NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962
Target: Drug Metabolite
CB 3703
T30761
Synonym: CB3703,NSC 289522,CB-3703
Target:
Trimetrexate
T17164
Synonym: CI-898
Target: Others
CH-1504
T27002
Synonym: CH 1504,MobileTrex
Target:
Cycloguanil nitrate
T69591
Synonym:
Target:
Chlorasquin
T23883
Synonym: Ccnsc-529,861,Ccnsc 529,861,SK 29861,Ccnsc529,861,SK-29861
Target:
Metioprim
T24459
Synonym: Ro126995,Ro 126995,He 909,He909,Ro 12-6995
Target:
Epiroprim
T25381
Synonym: Epiroprime,Ro11-8958,Ro 11-8958,Ro-11-8958
Target:
Lysine-methotrexate
T24427
Synonym: ADMPL
Target:
Cycloguanil D6 Nitrate
T10915
Synonym: Chlorguanide triazine D6 Nitrate
Target: Others
Aminopterin sodium
T7730L
Synonym: NSC739,NSC 739 [as the base],NSC-739
Target:
Methasquin
T70080
Synonym:
Target:
TRC-19
T29003
Synonym:
Target:
Ornithine-methotrexate
T24571
Synonym: ADMPO
Target:
Aminopterin N-hydroxysuccinimide ester
T25079
Synonym: Nhs-aminopterin,N-Hydroxysuccinimide aminopterin
Target:
Dihydrohomofolic acid
T25332
Synonym:
Target:
Ro 20-0657/000
T12742
Synonym:
Target: Others
Cycloguanil D6
T10916
Synonym: Chlorguanide triazine D6
Target: Others
Proguanil
T22409
Synonym: chloroguanide,chlorguanide
Target: Others
Dichloromethotrexate
T25324
Synonym: NSC 29630,3988-B-129-4,NSC29630,Dichloroamethopterin,NSC-29630
Target:
NSC309401
T79912
Synonym:
Target:
Piritrexim isethionate
T68684
Synonym:
Target:
Pralatrexate, (S)-
T25981
Synonym:
Target:
Pralatrexate, (R)-
T25980
Synonym:
Target:
NSC309401 dihydrochloride
T81639
Synonym:
Target:
Emofolin sodium
T25374
Synonym: NSC139490,MeTHHF disodium,NSC-139490,NSC 139490
Target:
Trimetrexate glucuronate
T63985
Synonym:
Target:
EGFR/HER2-IN-7
T61272
Synonym:
Target:
Trimethoprim lactate
T39862
Synonym:
Target:
Trimethoprim sulfate
T69089
Synonym:
Target:
DHFR-IN-10
T82571
Synonym:
Target:
Baquiloprim
T75259
Synonym:
Target:
OYYF-175
T60726
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T15128 Dihydrofolic acid 7,8-Dihydrofolic acid,Dihydrofolate Others
Dihydrofolic acid (7,8-Dihydrofolic acid) is a folic acid derivative that produces tetrahydrofolic acid in the presence of dihydrofolic acid reductase.
T1153 Trimethoprim NIH 204,BW 56-72,NSC-106568 DHFR , DNA/RNA Synthesis , Antifolate , Antibacterial , Antibiotic
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Tra...
T7730 Aminopterin APGA,4-Aminofolic acid Antifolate
Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase

Natural Products

Dihydrofolic acid
T15128
Synonym: 7,8-Dihydrofolic acid,Dihydrofolate
Target: Others
Trimethoprim
T1153
Synonym: NIH 204,BW 56-72,NSC-106568
Target: DHFR, DNA/RNA Synthesis, Antifolate, Antibacterial, Antibiotic
Aminopterin
T7730
Synonym: APGA,4-Aminofolic acid
Target: Antifolate

Recombinant Proteins

Species：
E. coli (1)
Human (1)
Staphylococcus aureus (1)
Staphylococcus epidermidis (1)
Expression System：
E. coli (4)
Tag：
N-terminal 6xHis-tagged (2)
C-terminal 6xHis-tagged (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Cat No. Product Name Species Expression System
TMPH-01224 Dihydrofolate reductase Protein, Human, Recombinant (His) Human E. coli
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds...
TMPH-03535 Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) Staphylococcus aureus E. coli
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
TMPH-00608 Dihydrofolate reductase Protein, E. coli, Recombinant (His) E. coli E. coli
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
TMPH-03581 Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) Staphylococcus epidermidis E. coli
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
CORPORATE
About Us Careers Privacy Notice Events & News Terms & Conditions
SUPPORT
Contact Us Worldwide Distributors Quality Control Technical Support
RESOURCE
Product Catalog Product Citations Signaling Pathways Solution Calculators
FOLLOW OUR
Social Network
Newsletter Subscription
Subscribe to receive our lastest product updates and special offers!
Corporate
Support
Resource
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
TargetMol
Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved.