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Results for "

dihydrofolate

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    73
    TargetMol | Inhibitors_Agonists
  • Dye Reagents
    1
    TargetMol | Dye_Reagents
  • PROTAC Products
    1
    TargetMol | PROTAC
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    TargetMol | Antibody_Products
Trimethoprim
NSC-106568, NIH 204, BW 56-72
T1153738-70-5
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
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Dihydrofolic acid
Dihydrofolate, 7,8-Dihydrofolic acid
T151284033-27-6
Dihydrofolic acid (7,8-Dihydrofolic acid) is a folic acid derivative that produces tetrahydrofolic acid in the presence of dihydrofolic acid reductase.
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7-10 days
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10-Formyldihydrofolate
T2034028459-40-7
10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase.
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3-6 months
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5-Methyldihydrofolate
T2946059904-24-4
5-Methyldihydrofolate is the primary biologically active form of folate used for DNA reproduction, the cysteine cycle, and the regulation of homocysteine.
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8-10 weeks
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WR99210 hydrochloride(47326-86-3 free base)
WR99210 hydrochloride(47326-86-3 free base), 6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine
T17257L30711-93-4In house
WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mutant dihydrofolate reductases.
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CPS-11
CPS11, CPS 11, N-(Hydroxymethyl)thalidomide
T23911145945-21-7In house
CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line.
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6-8 weeks
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Piritrexim
BW 301U
T2464472732-56-0In house
Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinoma and metastatic breast cancer.
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6-8weeks
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Methotrexate Diglutamate
NSC-269401, NSC 269401, NSC269401
T2588641600-13-9In house
Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.
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7-10 days
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Talotrexin ammonium
T64295648420-92-2In house
Talotrexin ammonium is a non-polyglutamic acid antifolate. Talotrexin ammonium inhibits tumor growth by targeting dihydrofolate reductase (DHFR), thereby improving anti-tumor activity in a wide range of cancer models, helping to inhibit tumor growth.
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6-8weeks
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Pyrimethamine
RP 4753, Pirimetamin, Pirimecidan
T084958-14-0
Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
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Methotrexate
WR19039, NCI-C04671, CL14377, Amethopterin
T148559-05-2
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
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Methotrexate disodium
T80037413-34-5
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
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TargetMol
Epiroprim
Ro11-8958, Ro-11-8958, Ro 11-8958, RO 118958, Epiroprime
T2538173090-70-7
Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity, inhibiting Staphylococcus, Enterococcus, Pneumococcus, and Streptococcus.
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6-8 weeks
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Phototrexate
T411482268033-83-4In house
Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared withtrans-Phototrexate (IC50 = 34 μM).
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8-10 weeks
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Brodimoprim
T1985856518-41-3
Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile.
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6-8 weeks
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TargetMol | Inhibitor Sale
Fanotaprim
T366922120282-75-7
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor, suppressing the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM, a hDHFR IC50 of 308 ± 71 nM, and a hDHFR to TgDHFR selectivity ratio of 196.
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TargetMol | Inhibitor Sale
DHFR-IN-3
7-bromoquinazoline-2,4-diamine
T3693137553-43-6
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is a dihydrofolate reductase (DHFR) inhibitor.
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TargetMol | Inhibitor Sale
Cycloguanil hydrochloride
Chloroguanide Triazine
T5420152-53-4
Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
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TargetMol | Inhibitor Sale
Cycloguanil D6 Nitrate
Chlorguanide triazine D6 Nitrate
T10915
Cycloguanil D6 Nitrate is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil.
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7-10 days
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Cycloguanil D6
Chlorguanide triazine D6
T10916
Cycloguanil D6 is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil.
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Ro 20-0657/000
T1274229606-06-2
Ro 20-0657 000 is a metabolite of Trimethoprim, an inhibitor of dihydrofolate reductase and an antibacterial agent used in human and veterinary medicine.
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4-6 weeks
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Trimetrexate
CI-898
T1716452128-35-5
Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.
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6-8 weeks
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WR99210
WR-99210, WR 99210, BRL 6231 free base
T1725747326-86-3
WR99210 (BRL 6231 free base) is an orally available dihydrofolate reductase (DHFR) inhibitor with antiparasitic activity, often used in combination with dapsone to study Mycobacterium avium complex (MAC).
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1-2 weeks
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DHFR-IN-20
T200479
DHFR-IN-20 (Compound LA1) is an inhibitor of dihydrofolate reductase (DHFR) targeting the malignant strains of the malaria parasite. It exhibits inhibition constants (Kis) of 0.16 nM, 0.30 nM, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively. Additionally, DHFR-IN-20 demonstrates antimalarial activity, with IC50 values of 1.4 nM against parasites carrying the wild-type (TM4 8.2) PfDHFR enzyme and 1.6 μM against those with the quadruple mutation (V1 S)PfDHFR.
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