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Results for "

ckd

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    25
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • Inhibitory Antibodies
    1
    TargetMol | Inhibitory_Antibodies
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    TargetMol | Inhibitors_Agonists
R-268712
T16708879487-87-3
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.
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CKD-519
T149761402796-27-3
CKD-519 is a selective inhibitor of cholesteryl ester transfer protein (CETP). It inhibits CETP-mediated transfer of cholesteryl ester in human serum (IC50: 2.3 nM).
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8-10 weeks
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CKD-712
CKD 712,CKD712
T27033626252-75-3
CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by suppressing cyclin A, cyclin B and C
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6-8 weeks
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CKD 602
T36700
Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo.
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Lockdown
T7184538103-05-8
Lockdown is a reversible and non-competitive PPM1F inhibitor. Lockdown is selective for PPM1F, because this compound does not inhibit other protein phosphatases in vitro and does not induce additional phenotypes in PPM1F knockout cells. Lockdown acts in a dose-dependent, allosteric manner with high selectivity for PPM1F
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6-8 weeks
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Bis-T-23
Bis T-23, Bis-T 23, AG1717
T30479171674-76-3In house
Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).
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6-8weeks
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lobeglitazone sulfate
Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang, CKD-501 Sulfate, CKD501 Sulfate, CKD-501, CKD501, CKD 501 Sulfate, CKD 501
T27841763108-62-9
Lobeglitazone Sulfate(CKD-501 Sulfate) is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2 diabetes mellitus (T2DM).
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6-8 weeks
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TargetMol | Inhibitor Sale
S516
T128231016543-77-3
S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
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6-8 weeks
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Valecobulin hydrochloride
CKD-516 hydrochloride
T132781240321-53-2
Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516. Valecobulin hydrochloride (CKD-516 hydrochloride) has a potent inhibitory effect on β-tubulin polymerization and has significant anti-tumor activity against solid tumors in mice and humans.
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6-8 weeks
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Valecobulin
CKD-516
T13278L1188371-47-2
Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.
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1-2 weeks
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CDDO-dhTFEA
T136041191265-33-4
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).
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TargetMol | Inhibitor Sale
Beloranib
ZGN 440, CKD-732
T19871251111-30-5
Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.
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3-6 months
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Tenofovir disoproxil aspartate
CKD-390,CKD390,CKD 390
T289451571075-19-8
Tenofovir disoproxil aspartate, a nucleotide reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection.
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    Zevaquenabant
    (S)-MRI-1867
    T394101998760-00-1
    Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD).
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    Belotecan
    T62435256411-32-2
    Belotecan (CKD-602 free base) is a camptothecin derivative and DNA topoisomerase I inhibitor that blocks the cell cycle, induces apoptosis, and has antitumor properties, making it useful for cancer research.
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    10-14 weeks
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    trpc5-in-4
    T625892762315-39-7
    TRPC5-IN-4, a potent and safe TRPC inhibitor, exhibits IC50 values of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively, indicating high efficacy. It does not cause damage to liver and kidney cellular components, making it suitable for chronic kidney disease (CKD) research [1].
    • Inquiry Price
    10-14 weeks
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    Lobeglitazone
    T69011607723-33-1
    Lobeglitazone, also known as CKD-501, is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.
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    1-2 weeks
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    BI-685509
    T733321579514-06-9
    BI-685509 is a potent and orally active sGC activator. BI-685509 restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. BI-685509 can be used in research of chronic kidney disease (CKD) and diabetic kidney disease (DKD) .
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    10-14 weeks
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    Belotecan hydrochloride
    CKD-602
    T7551213819-48-8
    Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
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    Belotecan hydrochloride (GMP)
    T7551-GMP213819-48-8
    Belotecan hydrochloride (GMP) refers to the GMP grade reagents of Belotecan hydrochloride. Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
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      COR-001
      T76947
      COR-001, a human anti-IL-6 monoclonal antibody, efficiently lowers serum CRP levels and exhibits anti-inflammatory properties. It is potentially useful in researching chronic systemic inflammation and cardiovascular diseases linked to chronic kidney disease (CKD) [1].
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      2-4 weeks
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      Poricoic acid A
      Poricoic acid A(F)
      T8181137551-38-3
      Poricoic acid A (Poricoic acid A(F)) is a natural product with antitumor activity. It also enhances melatonin inhibition of AKI-to-CKD transition by regulating the Gas6 AxlNFκB Nrf2 axis.
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      TargetMol | Inhibitor Sale
      NS-3-008 hydrochloride
      NS-3-008 HCl
      T84941172854-54-4
      NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0 G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).
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      KP-6
      TP29702102414-23-1
      KP-6 is a peptide that acts as an inhibitor of the Wnt β-catenin signaling pathway. It suppresses TGF-β and disrupts key signals that lead to rapid fibrosis in vivo. KP-6 helps prevent kidney tissue damage and fibrosis, offering the potential to reverse the progression of chronic kidney disease (CKD).
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