Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • Apoptosis
    (8)
  • Antibacterial
    (3)
  • Epigenetic Reader Domain
    (3)
  • Histone Methyltransferase
    (3)
  • Autophagy
    (2)
  • Parasite
    (2)
  • Adrenergic Receptor
    (1)
  • Akt
    (1)
  • Antioxidant
    (1)
  • Others
    (13)
Filter
Search Result
Results for "

anti-leukemic

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    42
    TargetMol | Inhibitors_Agonists
  • Inhibitory Antibodies
    3
    TargetMol | Inhibitory_Antibodies
  • PROTAC Products
    2
    TargetMol | PROTAC
  • Natural Products
    4
    TargetMol | Natural_Products
nor-NOHA acetate
Nω-Hydroxy-nor-L-arginine acetate
T122401140844-63-8In house
nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a reversible inhibitor of arginase with anti-leukemic activity, effective in treating endothelial dysfunction, immunosuppression, and metabolism regulation.
  • Inquiry Price
7-10 days
Size
QTY
LeuRS-IN-1
T387751364914-72-6In house
LeuRS-IN-1 is an orally active and potent Mycobacterium tuberculosis leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity, inhibits M.tb LeuRS, inhibits HepG2 protein synthesis, and can be used in leukemia research.
  • Inquiry Price
Size
QTY
Dihydro-5-azacytidine
DHAC, NSC264880, 5,6-Dihydro-5-azacytidine
T4071362488-57-7In house
Dihydro-5-azacytidine (DHAC) is an active nucleoside analog with anti-leukemic activity that inhibits cell growth and induces DNA hypomethylation.Dihydro-5-azacytidine is used in the study of leukemia and tumors.
  • Inquiry Price
Size
QTY
Piribedil
EU-4200, Trivastan, ET-495, Trivastal
T32783605-01-4
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
  • Inquiry Price
Size
QTY
LeuRS-IN-1 hydrochloride
T387731364683-67-9
LeuRS-IN-1 hydrochloride is an orally active and highly potent inhibitor of Mycobacterium tuberculosis leucyl-tRNA synthetase with anti-leukemic activity and anti-malarial activity, inhibits M.tb LeuRS, inhibits HepG2 protein synthesis, and can be used in the study of leukemia.
  • Inquiry Price
10-14 weeks
Size
QTY
MI-192
T218981415340-63-4In house
MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50 values of 30 nM and 16 nM, respectively. It exhibits greater selectivity for HDAC2 3 over other HDAC isomers and induces apoptosis in myeloid leukemic cells, indicating potential therapeutic use in leukemia and as an anti-stroke agent [1] [2].
  • Inquiry Price
6-8 weeks
Size
QTY
Oroxylin A
Baicalein 6-methyl ether, 6-Methoxybaicalein
T6S1315480-11-5
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP LIP CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562 ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K Akt NF-κB pathway, and probably served as a most promising agent for CML treatment.
  • Inquiry Price
Size
QTY
Eltanexor
ONO-7706, KPT-8602, ATG-016
T11766L1642300-52-4
Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Resveratrol analog 1
T12708861446-16-4
Resveratrol analog 1, an analog of Resveratrol, is a natural polyphenolic phytoalexin with antioxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.
  • Inquiry Price
7-10 days
Size
QTY
VTP50469
T133362169916-18-9
VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction with potent anti-leukemic activity with a Ki of 104 pM.
  • Inquiry Price
Size
QTY
ART838
ART-838, ART 838
T201951676620-45-4
ART838 is a dimeric pimeloyl urea compound notable for its potent anti-leukemic activity and favorable pharmacological properties. In vitro, ART-838 exhibits submicromolar inhibitory concentrations against all leukemia cell lines, demonstrating anti-leukemic efficacy 88 times greater than artemether. This compound remains in the body for extended periods and works synergistically with other anti-leukemic agents and novel kinase inhibitors to suppress leukemia cell growth. In immunodeficient NOD-SCID-IL2Rgnull (NSG) mice, ART-838 attains a plasma half-life longer than that of artemether, sustaining effective anti-leukemic concentrations for over 8 hours. Intermittent ART-838 treatment notably inhibited the growth of acute leukemia xenografts and primary grafts in NSG mice, surpassing the efficacy of artemether.
  • Inquiry Price
Size
QTY
Denotivir
Wratizolin, Vratizolin
T20342651287-57-1
Denotivir (Vratizolin) is an orally active antiviral agent effective against herpes simplex virus (HSV) and varicella-zoster virus (VZV). It inhibits the proliferation of various cancer cells and possesses anti-leukemic properties. Additionally, Denotivir suppresses the production of TNF-α, IL-1, and IL-6, demonstrating immunosuppressive effects.
  • Inquiry Price
Size
QTY
Purinostat
T2042691929583-17-4
Purinostat is a selective inhibitor of HDACI IIb with potential anti-leukemic properties. Its mesylate form, Purinostat mesylate, is effective at inhibiting the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDACI IIb, impacting several crucial factors for leukemia stem cell (LSC) survival, such as c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Additionally, Purinostat mesylate enhances glutamate metabolism in LSCs by increasing GLS1.
  • Inquiry Price
10-14 weeks
Size
QTY
FLT3-IN-29
T204337
FLT3-IN-29 (Compound MY-10) is an FLT3 inhibitor with IC50 values of 6.5 nM and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants, respectively. It induces cell cycle arrest at the G0 G1 phase and effectively triggers apoptosis (Apoptosis). Additionally, FLT3-IN-29 reduces reactive oxygen species (ROS) and mitochondrial membrane potential (MMP), displaying anti-leukemic properties.
  • Inquiry Price
Size
QTY
DP-15
T2050433033837-71-4
DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]
  • Inquiry Price
Size
QTY
Apoptosis inducer 36
T2056142831492-41-0
Apoptosisinducer 36 (Compound 42) exhibits anti-leukemic activity by reducing leukemia stem cells (LSC) and inducing differentiation. It inhibits proliferation of AML cells by causing cell cycle arrest in the G1 phase, and induces PANoptosis, which includes apoptosis, pyroptosis, and necrosis.
  • Inquiry Price
10-14 weeks
Size
QTY
Crebanine
T2S221525127-29-1
1. Crebanine iv 5mg kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease t
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
AC-4-130
T354291834571-82-2
AC-4-130, a powerful inhibitor of the SH2 domain of STAT5, effectively hinders STAT5 activation, dimerization, nuclear translocation, and transcription of genes reliant on STAT5. This compound directly binds to STAT5, ultimately leading to cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 exhibits notable anti-cancer properties and effectively suppresses abnormal STAT5 activity in acute myeloid leukemia (AML), making it a promising therapeutic option [1].
  • Inquiry Price
4-6 weeks
Size
QTY
AS-99 free base
T369772323623-93-2
AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity, blocking cell proliferation, inducing apoptosis and differentiation, downregulating MLL fusion target genes, and reducing the leukemia burden in vivo[1].
  • Inquiry Price
Size
QTY
AS-99 TFA
T36978
AS-99 TFA is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity. It blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo[1].
  • Inquiry Price
Size
QTY
THZ-P1-2
T394592058075-45-7
THZ-P1-2 is a selective and potent PI5P4K inhibitor with anti-leukemic activity that acts by disrupting mitochondrial homeostasis and autophagy.THZ-P1-2 induces cell death and mitochondrial damage, and can be used in the study of leukemias.
  • Inquiry Price
7-10 days
Size
QTY
Casein Kinase inhibitor A86
Casein Kinase inhibitor A86
T394822079069-01-3
Casein Kinase inhibitor A86 is a highly effective and orally bioavailable inhibitor of casein kinase 1α (CK1α) and also inhibits CDK7 (TFIIH) and CDK9 (P-TEFb). It induces apoptosis in leukemia cells, exhibiting substantial anti-leukemic effects.
    7-10 days
    Inquiry
    AS-85
    AS85
    T398612323623-80-7
    AS-85 is a cell permeable ASH1L inhibitor with anti-leukemic activity, inhibits the growth of leukemic cells, increases cLogP, decreases tPSA, and can be used in the study of leukemia.
    • Inquiry Price
    7-10 days
    Size
    QTY
    SK1-I hydrochloride
    BML-258 hydrochloride, BML258 hydrochloride
    T607982366222-05-9
    SK1-I hydrochloride is the salt form of SK1-I(BML-258). SK1-I is a selective and competitive sphingosine kinase 1 (SphK1) inhibitor and sphingosine analog that is inactive against SphK2 and a variety of other protein kinases, and possesses anti-leukemic potential to inhibit tumor cell growth and promote apoptosis.
    • Inquiry Price
    6-8 weeks
    Size
    QTY