anthelmintic

Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene utilized topically as an antiseptic for minor skin infection treatment.

Phenothiazine (ENT 38) is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis.

Nitazoxanide (NSC-697855) is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction.

α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.

Niclosamide is a classic salicylanilide antiparasitic drug and a multi-target, low-toxicity, broad-spectrum small-molecule modulator with anthelmintic and antitumor activity. Niclosamide disrupts the parasite’s energy metabolism by uncoupling mitochondrial oxidative phosphorylation, leading to reduced ATP production and ultimately killing the parasite. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells.

CMP-5 2HCl is a anthelmintic agent. CMP-5 2HCl shows EC100 of 5μM against H. contortus in vitro.

Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.

Brotianide (BAY-VA4059) has anthelmintic activity and is highly potent against liver fluke and gastric fluke infestations and can be used to treat acute, subacute and chronic liver fascioliasis infections in sheep.

CGP 20376 is a benzothiazole compound, an anthelmintic, with dual dose-dependent modulation of in vitro effects on the respiratory burst of eosinophils and antifibrillatory properties.

Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.

Dichlorophen (DDM) is a nontoxic laxative vermicide of chlorinated phenol compound. Dichlorophen is used as a veterinary fungicide, anthelmintic, and anti-protozoan, as well as an ingredient in antimicrobial soaps and shampoos. This agent probably acts by increasing the clearing of intestinal contents, thereby eradicating tapeworm infections from the intestines.

Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.

Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

Oxyclozanide (Oxyclozanid) is a salicylanilide anthelmintic used in grazing animals for fasciola and cestode infestations.

Avermectin B1 is served as anthelmintic and insecticide.

Moxidectin (CL301423) is an anthelmintic drug which kills parasitic worms, and is used for the prevention and control of heartworm and intestinal worms. It can be found in treatments prescribed for animals such as dogs, cats, horses, cattle and sheep. Application methods for moxidectin vary by treatment, and include oral, topical, and injectable solutions. Cydectin Pour On is a trade name for a formulation for use on cattle and red deer.

Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent. This compound is commonly used as an anthelmintic to treat parasitic worm infections, effectively paralyzing nematodes by inhibiting their neuromuscular activity.

Diethylcarbamazine citrate (Caritrol) is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Loa loa. It is an inhibitor of arachidonic acid metabolism in filarial microfilaria.

Febantel is an anthelmintic. It is used for veterinary use on dogs, cats, cattle, sheep, goats, pig, and poultry against roundworms and tapeworms.

Piperazine citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. It used as an Anthelmintic.

Genistein (NPI 031L) is a naturally occurring soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor, antioxidant, and anthelmintic properties, and also produces estrogen-like effects in the body.

Dymanthine (ADMA 18) is an agent of veterinary anthelmintic.

Ascaridole (NSC-406266) acts as an anthelmintic compound that repels parasitic helminths (worms) in humans and plants and has weak antimalarial activity.

Nitroxynil (4-Hydroxy-3-iodo-5-nitrobenzonitrile) is an anthelmintic compound that effectively targets parasites in both adult and immature stages. It is extensively employed in investigations pertaining to Fasciola hepatica infection.