a 113

A 113 is a biochemical.

[Ala113]MBP(104-118) acetate is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 28-62 μM.

[Ala113]MBP(104-118) TFA is a peptide inhibitor that acts noncompetitively against protein kinase C (PKC), with inhibitory concentrations (IC50) ranging from 28 to 62 μM [1].

Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).

P-113 acetate is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5, shows good safety and efficacy profiles in gingivitis and human immunodeficiency virus (HIV) patients with oral candidiasis.

FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity

SARS-CoV-2-IN-113 (Compound 24) is a sulfonyl hydrazine derivative that exhibits antiviral activity against SARS-CoV-2 infection, with an IC50 of 8.320 μM. It effectively inhibits the entry and replication of SARS-CoV-2 by downregulating genes and proteins such as Spike, ACE-2, and RdRp. SARS-CoV-2-IN-113 shows high selectivity and low cytotoxicity, making it a valuable candidate for COVID-19 research.

BW-AQ-113 is a derivative of Anthraquinone that specifically degrades MDM2 and activates the p53 pathway. It exhibits IC50 values of 0.12 μM in Molt-4 cells and 0.2 μM in EU-1 cells. In p53-deficient K562 cells, p53-mutant T98G cells, and p53-inhibited HeLa cells, its IC50 values are 0.74, 5.2, and 2.1 μM, respectively. BW-AQ-113 induces apoptosis by downregulating the anti-apoptotic gene Bcl-2 and upregulating pro-apoptotic genes Bax and CASP3. Additionally, BW-AQ-113 can be utilized in research on hematologic malignancies with wild-type p53.

Anti-inflammatory agent 113 (compound B5) is a cathepsin L (CTSL) inhibitor and anti-inflammatory compound with an IC50 for CTSL of 5.52 μM. It hinders the maturation of CTSL, downregulates the activation of NF-κB and p38 MAPK signaling pathways, and binds stably at the CTSL active site through non-covalent interactions with Asp162, Cys25, and Glu63. This compound also inhibits the production of pro-inflammatory cytokines (IL-6, IL-8), reduces pulmonary infiltration of inflammatory cells, and alleviates lung tissue damage. Anti-inflammatory agent 113 is applicable in research on acute lung injury.

AChE-IN-113 is a selective acetylcholinesterase (AChE) inhibitor with a Ki value of 8.3 μM for electric eel acetylcholinesterase. It can be utilized in Alzheimer's disease research.

P-113 is a peptide with antimicrobial activity.

MOG (89-113), human is a peptide fragment of human myelin oligodendrocyte glycoprotein.

C13-113-tri tail, a cationic lipid-like compound, features a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. It is capable of being formulated into a lipid nanoparticle (LNP).

C13-113-tetra tail, a cationic lipid-like compound, features a polar amino alcohol head group, a tertiary amine linker, and four hydrophobic carbon-13 tails. It can be formulated into a lipid nanoparticle (LNP).

"113-O12B is an ionizable cationic lipidoid containing a disulfide bond, utilized in the generation of lipid nanoparticles (LNPs) for mRNA delivery [1]."

C12-113, a lipidoid delivery agent, effectively transfects siRNA into cells and, when combined with additional lipids, forms lipid nanoparticles (LNPs). These LNPs facilitate the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice [1] [2].

113-O16B, an ionizable cationic lipidoid featuring a disulfide bond, is utilized in producing lipid nanoparticles (LNPs) for mRNA delivery [1].

SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.

WWL113 is a selective and orally active inhibitor of Ces3 (IC50: 120 nM) and Ces1f (IC50: 100 nM), exhibiting excellent selectivity for the 60-kDa serine hydrolase.

Antifungalagent 113 (compound 9a) serves as an effective antifungal and antibacterial agent. It exhibits strong inhibitory activity against both S. aureus and methicillin-resistant S. aureus.

EGFR-IN-113 (compound II-1) is an EGFR kinase inhibitor with an IC50 of 14.79 μM. It induces apoptosis and inhibits cell proliferation by downregulating the Akt and Erk1/2 signaling pathways. EGFR-IN-113 is applicable in research on EGFR-driven cancers, such as lung cancer, pancreatic cancer, and breast cancer.

α-Glucosidase-IN-113 is an inhibitor of α-glucosidase, with an IC50 of 17.52 μM. It exhibits anti-glycation activity and can inhibit the formation of advanced glycation end-products. α-Glucosidase-IN-113 is useful in research related to type 2 diabetes.

FAUC-113 is an antagonist of Dopamine D4 receptor.

NT113 is a pan-ERBB inhibitor with high brain penetrance. NT113 is active against GBM xenografts in which wild-type EGFR or EGFRvIII is highly expressed. NT113 inhibits the growth of glioblastoma xenografts with EGFR amplification. NT113 has inhibitory ac