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Cat No. | Product Name | Synonyms | Targets |
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T9845 | Thrombin inhibitor 5 | ||
Thrombin inhibitor 5 (compound 385) is a thrombin inhibitor with IC 50s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for venous thromboembolism research[1]. | |||
T7674 | Thrombin Receptor Activator for Peptide | Protease-activated Receptor | |
Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD). | |||
T19580 | Thrombin (MW 37kDa) | Thrombin | Thrombin |
Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease. | |||
T10081 | Thrombin inhibitor 1 | Thrombin | |
Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM). | |||
T7496 | Thrombin Receptor Activator for Peptide 5 (TRAP-5) | Thrombin Receptor Activator for Peptide | Protease-activated Receptor |
Thrombin Receptor Activator for Peptide 5 (TRAP-5), also known as Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), is employed in coronary heart disease (CHD) research. | |||
T17091 | Thrombin Inhibitor 2 | Others | |
Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor. Thrombin Inhibitor 2 has antithrombotic activity. | |||
T36777 | Thrombin Receptor Agonist Peptide (trifluoroacetate salt) | ||
Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor. It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma. TRAP-14 (100 μM) ... | |||
T36553 | Thrombin Receptor Peptide Ligand (trifluoroacetate salt) | ||
Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 μM to inhibit platelet aggregation in vitro). It inhibits α-thrombin and platelet aggregation induced by thrombin receptor activating... | |||
T7625 | TRAP-6 | PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA) | Protease-activated Receptor |
TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1). | |||
T72448 | Thrombin inhibitor 6 | ||
Thrombin Inhibitor 6, with an IC 50 of 1 nM, acts as a potent anticoagulant by inhibiting thrombin. | |||
TP2234 | Coagulation factor II (thrombin) B chain fragment [Homo sapiens] | Others | |
Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a ser... | |||
T80512 | Thrombin receptor peptide ligand | Thrombin | |
Thrombin receptor peptide ligand, a thrombin receptor antagonist, serves as an antithrombotic agent [1]. | |||
T3757 | NQ301 | Thrombin , Platelet aggregation | |
NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL). | |||
T1986L | Atopaxar Hydrobromide | Protease-activated Receptor | |
Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome. | |||
T1986 | Atopaxar | E5555,ER-172594-00 | Protease-activated Receptor |
Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome. | |||
T7137 | I-191 | Protease-activated Receptor | |
I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells. | |||
TQ0012 | AZ3451 | Protease-activated Receptor | |
AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM). | |||
T12870 | SCH79797 dihydrochloride | Apoptosis , Others , Protease-activated Receptor | |
SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects. | |||
T6594 | MNS | Syk , Src , p97 | |
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. | |||
T6295 | Dabigatran | BIBR 953,BIBR 953ZW | Thrombin |
Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients... | |||
T2370 | AC-55541 | AOB2796 | Proteasome , Protease-activated Receptor |
AC-55541 (AOB2796) is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. | |||
T22246 | Argatroban Monohydrate | Thrombin | |
Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi. | |||
T6370 | AEBSF hydrochloride | AEBSF HCl,Pefabloc SC | Thrombin , Serine Protease , Influenza Virus |
AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin. | |||
TP1046 | SLIGRL-NH2 | Protease-Activated Receptor-2 Activating Peptide | Protease-activated Receptor |
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a protease-activated receptor-2 (PAR-2) agonist that induces non-histaminergic pruritus. | |||
T5519 | Bivalirudin | BG-8967,Hirulog-1 | Thrombin |
Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities. | |||
T0155 | Argatroban | MCI-9038,MD-805,Argipidine | Thrombin |
Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi. | |||
T0389 | Dabigatran etexilate | BIBR 1048 | Thrombin |
Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. | |||
T7013 | Vorapaxar | SCH 530348,MK-5348 | Protease-activated Receptor |
Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM). | |||
T1893 | Parmodulin 2 | ML 161 | Protease-activated Receptor |
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thromb... | |||
T22323 | Enoxaparin sodium | Thrombin | |
Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percu... | |||
T5133 | Dabigatran Etexilate Mesylate | BIBR 1048MS,Dabigatran etexilate methanesulfonate | Thrombin |
Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM). | |||
T17265 | Ximelagatran | EXANTA,H 376-95,H37695,H 376/95,H-37695,H 37695 | Thrombin |
Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo. | |||
T8917 | PAR-2-IN-1 | IUN76750 | Protease-activated Receptor |
PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects. | |||
T3098 | Vorapaxar sulfate | SCH 530348 sulfate,Zontivity,vorapaxar monosulfate | Protease-activated Receptor |
Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist. | |||
TP1065 | PAR-4 Agonist Peptide, amide TFA | PAR-4-AP (TFA),AY-NH2 (TFA) | Protease-activated Receptor |
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)), is a selective activator of the proteinase-activated receptor-4 (PAR-4), demonstrating specificity by not influencing PAR-1 or PAR-2, and its activity can be inhibited b... | |||
T10951 | Dabigatran ethyl ester hydrochloride | Others , Thrombin | |
Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor. | |||
T7513 | Protease-Activated Receptor-2, amide | SLIGKV-NH2 | Protease-activated Receptor |
Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M) | |||
T2368 | Edoxaban Tosylate Monohydrate | DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban | Factor Xa , Thrombin |
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. | |||
T7623 | PAR-4 Agonist Peptide, amide | AY-NH2,PAR-4 Agonist Peptide, amide(2TFA),PAR-4-AP | Protease-activated Receptor |
PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4). | |||
T4186 | AC-264613 | AC264613 | Protease-activated Receptor |
AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613(AC264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macropha... | |||
T40711 | H-D-Phe-Pip-Arg-pNA dihydrochloride | S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride | Others |
H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thromb... | |||
T7573 | TFLLR-NH2 | TFLLR-NH2(2TFA) | Protease-activated Receptor |
TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM). | |||
T7380 | Protease-Activated Receptor-4 | Protease-activated Receptor | |
Protease-Activated Receptor-4 is the proteinase-activated receptor-4 (PAR4) agonist, with Antiplatelet Therapy | |||
T22676 | Prothrombin (474-477) [Mus musculus] | Others | |
Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothro... | |||
T9892 | JAMM protein inhibitor 2 | Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]- | Others |
JAMM protein inhibitor 2 (Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-) is an inhibitor of JAMM protease and can be used for anticancer studies. The IC50s are 10 μM, 46 μM, and 89 μM for thrombin,... | |||
T36951 | N-(p-Tosyl)-GPR-pNA acetate | Others | |
N-(p-Tosyl)-GPR-pNA acetate is a colorimetric substrate for thrombin that can act as a measure of thrombin activity. | |||
T8362 | Benzamidine hydrochloride | Benzamidine HCl | Serine/threonin kinase , Serine Protease |
Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively). | |||
T25364L | Efegatran sulfate | LY294468 sulfate,GYKI-14766 sulfate,LY 294468 sulfate,LY-294468 sulfate | Thrombin |
Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders. | |||
T8556 | Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base) | Z-Gly-Gly-Arg-AMC TFA | Others |
Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base) is a thrombin-specific fluorogenic substrate for testing thrombin generation in PRP and platelet-poor plasma (PPP). | |||
T11668 | IQB-782 | Others | |
IQB-782 shows a potent mucolytic-expectorant activity. IQB-782 is a cysteine derivative. IQB-782 has inhibition for thrombin activatable fibrinolysis inhibitor (TAFI), with an Ki(app) of 0.14 μM. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3839 | Cycloolivil | Isoolivil | Free radical scavengers , Others , Platelet aggregation |
Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees. Cycloolivil has antioxidant activity, it may prevent thrombotic complications associated t... | |||
TN1054 | Loureirin C | Others | |
Loureirin C can inhibit the activities of thrombin in vitro effectively. | |||
T3S0601 | Buddlejasaponin IVb | Saikosaponin 1b | Others |
1. Buddlejasaponin IVb (Saikosaponin 1b)(200 uM) can shorten thrombin time (TT) by 20.6 %, suggests that it has hemostasis efficacy. | |||
T3781 | Jujuboside B | Others | |
Jujuboside B has potent inhibitory effects on collagen-, thrombin-, AA-, and ADP-induced aggregation, and also exhibits superior protection on the thromboembolic model. | |||
T3793 | (20R)-Ginsenoside Rh1 | 20(R)-Ginsenoside Rh1 | Others |
(20R)-Ginsenoside Rh1 (20(R)-Ginsenoside Rh1) can inhibit the thrombin-induced conversion of fibrinogen to fibrin. | |||
TN3831 | (-)-Denudatin B | Denudatin B | ATPase , Potassium Channel , Calcium Channel , PAFR |
(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin. | |||
T5S0896 | Loureirin A | Akt , PI3K | |
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept... | |||
T5S2358 | Dehydrocorydaline | Dehydrocorydalin,13-Methylpalmatine | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz... | |||
TN4917 | Rosenonolactone | Others | |
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin. | |||
T36532 | SCH 38519 | ||
SCH 38519 is an isochromanequinone fungal metabolite originally isolated from Thermomonospora. It inhibits aggregation induced by thrombin , as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 μ... | |||
TN4860 | Pueroside B | COX , PPAR | |
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A rece... | |||
TN6014 | Norcepharadione B | ||
Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05025 | Thrombin Receptor Protein, Human, Recombinant (His) | Human | HEK293 |
TMPY-04996 | Coagulation Factor II Protein, Rat, Recombinant (His) | Rat | HEK293 |
Coagulation Factor II Protein (FII, F2 Protein or Prothrombin) is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Coagulation ... | |||
TMPY-01791 | Coagulation Factor II Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Coagulation Factor II Protein (FII, F2 Protein or Prothrombin) is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Coagulation ... | |||
TMPH-00038 | Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) | Agkistrodon contortrix | E. coli |
Thrombin-like snake venom serine protease that cleaves beta chain of fibrinogen (FGB), releasing fibrinopeptide B. Has a coagulant activity activating blood coagulation factors V (F5) and XIII (F13A1). | |||
TMPJ-00649 | CPB2 Protein, Human, Recombinant (His) | Human | Human Cells |
Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the pl... | |||
TMPJ-00243 | Serpin B6 Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in th... | |||
TMPY-00916 | Antithrombin III Protein, Human, Recombinant (His) | Human | HEK293 |
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prog... | |||
TMPY-02471 | Antithrombin III Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prog... | |||
TMPH-01974 | Prothrombin Protein, Human, Recombinant (His) | Human | Yeast |
Prothrombin Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPH-01975 | Prothrombin Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Prothrombin Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-01101 | Coagulation factor X/F10 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the... | |||
TMPY-02185 | Coagulation factor XIII B/F13B Protein, Human, Recombinant (His) | Human | HEK293 |
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ... | |||
TMPY-01278 | Apolipoprotein H/APOH Protein, Human, Recombinant (His) | Human | HEK293 |
Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipop... | |||
TMPY-03271 | Thrombomodulin Protein, Rat, Recombinant (His) | Rat | HEK293 |
Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the ... | |||
TMPY-01254 | Serpin D1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibiti... | |||
TMPY-05829 | Thrombomodulin Protein, Human, Recombinant (His) | Human | HEK293 |
Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the ... | |||
TMPY-00917 | Serpin D1 Protein, Human, Recombinant (His) | Human | HEK293 |
SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibiti... | |||
TMPH-00768 | SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc) | Gloydius ussuriensis | E. coli |
Thrombin-like snake venom serine protease. Has a coagulant activity. Acts on alpha-chains of fibrinogen (FGA) generating fibrinopeptide A. | |||
TMPY-01631 | Carboxypeptidase B2 Protein, Human, Recombinant (His) | Human | HEK293 |
Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are en... | |||
TMPY-02505 | Carboxypeptidase B2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are en... | |||
TMPY-04490 | Carboxypeptidase B2 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are en... | |||
TMPH-00215 | SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) | Bothrops jararaca | E. coli |
Thrombin-like snake venom serine protease that clots fibrinogen by releasing fibrinopeptide A from the alpha chain of fibrinogen (FGA), induces platelet aggregation through its interaction with GPIb (GP1BA/GP1BB), and ac... | |||
TMPH-00324 | SVTLE Protein, Calloselasma rhodostoma, Recombinant (His) | Calloselasma rhodostoma | Yeast |
Thrombin-like snake venom serine protease that acts as an anticoagulant. It cleaves fibrinogen (FGA) to split off the A-fibrinopeptides (A, AY and AP), but not the B-fibrinopeptide. The resulting fibrin polymers are impe... | |||
TMPH-01577 | KRT18 Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT... | |||
TMPH-01578 | KRT18 Protein, Human, Recombinant (His) | Human | HEK293 |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT... | |||
TMPJ-00452 | Serpin A1a Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elast... | |||
TMPJ-00796 | Serpin E2 Protein, Human, Recombinant (His) | Human | Human Cells |
Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal panc... | |||
TMPH-00213 | Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc) | Bothrops atrox | E. coli |
Inhibits fibrinogen interaction with platelets. Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor a... | |||
TMPK-01043 | VEGFC Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet... | |||
TMPK-01044 | VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet... | |||
TMPJ-00490 | Serpin A5 Protein, Human, Recombinant (His) | Human | Human Cells |
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent i... | |||
TMPJ-01069 | Serpin A1e Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-... | |||
TMPH-03163 | SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc) | Protobothrops flavoviridis | E. coli |
Thrombin-like snake venom serine protease that clots fibrinogen (FGA) by releasing fibrinopeptide A. According to PubMed:8585090, only cleaves rabbit fibrinogen, whereas no specificity is described in PubMed:3910643 (tes... | |||
TMPJ-00605 | GPVI Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregat... | |||
TMPY-02242 | Serpin B6 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-... | |||
TMPJ-01282 | Serpin B12 Protein, Human, Recombinant (His) | Human | Human Cells |
Serpin B12 is a member of the serpin family. Serpins are the largest and most diverse family of serine protease inhibitors. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular f... | |||
TMPY-03604 | VAMP3 Protein, Human, Recombinant (His) | Human | E. coli |
VAMP3, also known as cellubrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components... | |||
TMPJ-01124 | PDIA6 Protein, Human, Recombinant (His) | Human | Human Cells |
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and br... | |||
TMPY-01718 | Serpin B12 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl... | |||
TMPJ-00707 | Coagulation factor X/F10 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin ... | |||
TMPJ-00505 | Serpin A1 Protein, Human, Recombinant (aa 25-418, His) | Human | Human Cells |
Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent,... | |||
TMPJ-00301 | Coagulation Factor X Protein, Human, Recombinant (hFc) | Human | Human Cells |
F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways a... | |||
TMPJ-00193 | TREML1 Protein, Human, Recombinant (hFc) | Human | Human Cells |
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-... | |||
TMPJ-01083 | Serpin E2 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice lea... | |||
TMPJ-00857 | Thrombomodulin Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a matu... | |||
TMPH-01333 | Fibrinogen beta chain Protein, Human, Recombinant (His) | Human | E. coli |
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one o... | |||
TMPJ-00734 | KNG1 Protein, Human, Recombinant (His) | Human | Human Cells |
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role ... | |||
TMPY-02628 | Neuroserpin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not ... | |||
TMPY-00821 | HGFA Protein (pro form), Human, Recombinant (His) | Human | HEK293 |
HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the act... | |||
TMPY-01241 | Neuroserpin Protein, Human, Recombinant (His) | Human | HEK293 |
Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not ... | |||
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Cat No. | Product Name | ||
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L7500 | Coagulation and Anticoagulation Compound Library | 154 compounds | |
A unique collection of 154 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS); |