ezh2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9700	EZH2-IN-2		Histone Methyltransferase
	EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM.		Histone Methyltransferase
T64043	EZH2-IN-13		Histone Methyltransferase
	EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.		Histone Methyltransferase
T67883	EZH2-IN-15	SHR2554	Histone Methyltransferase
	EZH2-IN-15 is a specific inhibitor of histone modifier enhancer of zeste 2 (EZH2). EZH2 is aberrantly overexpressed in a number of human cancers that controls the adaptive response via regulation of Treg activity. Intrat...		Histone Methyltransferase
T25400	EZH2-IN-3	EZH2 inhibitor 3,EZH2-inhibitor-3
	EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.
T40310	PARP/EZH2-IN-1	PARP/EZH2-IN-1
	PARP/EZH2-IN-1 is a novel compound that functions as a dual inhibitor for both PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for the treatment of triple-negative breast cancer with wild-type B...
T38827	EZH2-IN-5	EZH2-IN-5
	EZH2-IN-5 is a highly effective inhibitor of EZH2, displaying remarkable potency against both wild-type and mutant Tyr641 EZH2, with IC50 values of 1.52 nM and 4.07 nM, respectively.
T39497	EZH2-IN-4	EZH2-IN-4
	EZH2-IN-4 is a highly potent EZH2 inhibitor that can be taken orally. It exhibits inhibitory effects against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, with IC 50 values of 0.923 nM and 2.65 nM, respec...
T40323	EZH2-IN-6	EZH2-IN-6
	EZH2-IN-6 is an EZH2 inhibitor with enhanced antitumor activity.
T2079	GSK126	GSK2816126A,EZH2 inhibitor	Histone Methyltransferase
	GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).		Histone Methyltransferase
T6484	EI1	KB-145943,Ezh2 inhibitor	Apoptosis , Histone Methyltransferase
	EI1 (Ezh2 inhibitor) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.		Apoptosis , Histone Methyltransferase
TP2115	SAH-EZH2
	EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.
T73134	EZH2-IN-14
	EZH2-IN-14 is a selective inhibitor of EZH2 (Histone Methyltransferase), demonstrating potent inhibition with an IC50 value of 12 nM. It specifically targets the methyltransferase activity of EZH2/PRC2, effectively reduc...
T62896	EZH2-IN-12
	EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.
T73246	EZH2-IN-7
	EZH2-IN-7, a potent inhibitor of EZH2, addresses overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) that cause an abnormal increase in H3K27me3, contributing to the proliferation o...
T79780	IHMT-EZH2-426		Histone Methyltransferase
	IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effective...		Histone Methyltransferase
T64307	EZH2-IN-8
	EZH2-IN-8 is a potent inhibitor of EZH2. EZH2-IN-8 has the potential to be used in the study of cancer diseases.
T63970	EZH2-IN-11
	EZH2-IN-11 is a potent inhibitor of E2HZ. The oncogenic activity of EZH2 has been demonstrated in numerous studies in a variety of different cancer types and EZH2-IN-11 has shown research potential for cancer diseases.
T64208	EZH2-IN-9
	EZH2-IN-9 is a potent inhibitor of EZH2, whose overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) cause abnormal elevations in H3K27me3 and contribute to the growth and development...
T74602	PROTAC EZH2 Degrader-1
	PROTAC EZH2 Degrader-1 (Compound 150d), a potent inhibitor, effectively suppresses EZH2 methyltransferase activity, demonstrating an IC50 of 2.7 nM. EZH2 is crucial in various tumorigenesis and development processes [1].
T7305	JQEZ5		Histone Methyltransferase
	JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).		Histone Methyltransferase