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PROTAC EZH2 Degrader-35
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Catalog No. T218461 Copy Product Info
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PROTAC EZH2 Degrader-35 (compound U3i (44)) is a PROTAC protein degrader targeting EZH2 with a Ka of 16.19 nM against human EZH2. It demonstrates antiproliferative activity in triple-negative breast cancer cells while exhibiting minimal cytotoxicity in normal human epithelial, liver, and kidney cells. PROTAC EZH2 Degrader-35 is applicable in research related to triple-negative breast cancer.
PROTAC EZH2 Degrader-35
Cas No. 3034875-56-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PROTAC EZH2 Degrader-35 (compound U3i (44)) is a PROTAC protein degrader targeting EZH2 with a Ka of 16.19 nM against human EZH2. It demonstrates antiproliferative activity in triple-negative breast cancer cells while exhibiting minimal cytotoxicity in normal human epithelial, liver, and kidney cells. PROTAC EZH2 Degrader-35 is applicable in research related to triple-negative breast cancer. |
| In vitro | PROTAC EZH2 Degrader-35 binds with high affinity to the PRC2 complex, exhibiting a Kd value of 16.19 nM. It effectively inhibits the proliferation of triple-negative breast cancer cells MDA-MB-231 and MDA-MB-468, with IC50 values of 0.57 μM and 0.38 μM, respectively. This compound induces CRBN-dependent and proteasome-mediated degradation of PRC2 complex components, reduces oncogenic histone modifications, and triggers mitochondrial dysfunction and apoptosis in cancer cells while demonstrating minimal toxicity to normal human cells. |
| Molecular Weight | 1270.48 |
| Formula | C66H87N13O13 |
| Cas No. | 3034875-56-1 |
| Smiles | O=C(NCC=1C(=O)NC(=CC1C)C)C2=CC(=CC3=C2C=NN3C(C)C)C=4C=NC(=CC4)N5CCN(C(=O)CCCCCCCCC=6N=NN(C6)CCOCCOCCOCCOCCOCCOCCNC7=CC=CC=8C(=O)N(C(=O)C78)C9C(=O)NC(=O)CC9)CC5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: PROTAC EZH2 Degrader-35 in vitro | PROTAC EZH2 Degrader-35 formula | PROTAC EZH2 Degrader-35 molecular weight
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