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Search Results for " aryl hydrocarbon receptor "

Targets

51

Compounds

14

Natural Products

3

Recombinant Proteins

1

Isotope Products

Cat No. Product Name Synonyms Targets
T7202 ITE AhR , Aryl Hydrocarbon Receptor
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
T21966 MeBIO GSK-3 , Aryl Hydrocarbon Receptor , CDK
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.
T1960 YL-109 AhR , Aryl Hydrocarbon Receptor
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
T4608 PDM2 AhR , Aryl Hydrocarbon Receptor
PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
T20625 Prochloraz Sporgon,Prelude Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and...
T15410 GNF351 Aryl Hydrocarbon Receptor
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes wit...
T2448 CH-223191 CH 223191 AhR , Aryl Hydrocarbon Receptor
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
T5622 BAY-218 AHR antagonist 1 AhR , Aryl Hydrocarbon Receptor
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
T4607 CAY 10465 CAY10465,CAY10465 Exclusive AhR , Aryl Hydrocarbon Receptor
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
T10270 BAY 2416964 Aryl Hydrocarbon Receptor
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 192, IC50: 341 nM). It has the potential for cancer treatment.
T10007 1,4-Chrysenequinone Chrysene-1,4-dione AhR
1,4-Chrysenequinone (Chrysene-1,4-dione) is an activator of aryl hydrocarbon receptor (AhR).
TQ0257 FICZ 6-Formylindolo[3,2-b]carbazole Aryl Hydrocarbon Receptor
FICZ (6-Formylindolo[3,2-b]carbazole) is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
T1831 StemRegenin 1 SR1 AhR , Aryl Hydrocarbon Receptor
StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor.
T21704 5-fluoro 203 5F-203,NSC-703786 Others
5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells...
T13276 VAF347 Aryl Hydrocarbon Receptor
VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
T2623 PD98059 PD 98059 ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy.
T2148 Carbidopa monohydrate Carbidopa Hydrate,S(-)-Carbidopa Decarboxylase , Aryl Hydrocarbon Receptor
Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.
T0640 Benzyl butyl phthalate BBP,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate Others , Aryl Hydrocarbon Receptor
Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC.
T2707 Pifithrin-α hydrobromide Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide Ferroptosis , Aryl Hydrocarbon Receptor , p53
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
T8980 SGA360 Aryl Hydrocarbon Receptor
SGA360 is a selective aryl hydrocarbon (Ah) receptor modulator. It exhibits anti-inflammatory properties.
T10269 AHR antagonist 2 Aryl Hydrocarbon Receptor
AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively.
T5541 PDM11 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11 AhR
PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) is an antagonist of aryl hydrocarbon receptor (AhR)
T10325 ANI-7 Chk
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells and potently and selectively inhibits the growth of MCF-7 breast cancer cells (GI50: 0.56 μM).
T3637 Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide) Ferroptosis , p53
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder...
T10526 β-NF-JQ1 Others , PROTACs
β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BRD)-containing proteins and induce AhR and BRD protein inter...
T24960 10-Cl-BBQ 10ClBBQ Others
10-Cl-BBQ is a ligand of aryl hydrocarbon receptor (AhR).
T25235 CHD-5 CHD5 Others
CHD-5 is a selective antagonist of the aryl hydrocarbon receptor (AhR).
T20307 Benzyl 2-naphthyl ether AI3 00945,AI300945,AI3-00945 Others
Benzyl 2-naphthyl ether causes the activation of the aryl hydrocarbon receptor.
T16082 Mivotilate YH439 Others
Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.
T23686 AHR-activator-1023 Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023 Others
AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator.
T10258 AFP464 free base NSC710464 free base HIF
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
T10271 AHR antagonist 4 Others
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects.
T22528 6,2',4'-Trimethoxyflavone Others
The compound is an Aryl hydrocarbon receptor antagonist (EC50 = 0.9 μM). It also has no short term agonist activity and no species or promoter dependence.
T23400 StemRegenin 1 (hydrochloride) StemRegenin 1 (hydrochloride) (1227633-49-9 free base) Others
StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells).
T22725 DiMNF Others
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator. It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment.
T10272 AHR antagonist 5 Others
AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 39; IC50 < 0.5 μΜ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1.
T71938 MNF Others
MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS).
T10273 AhR modulator-1 Others
AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrog...
T70257 Avitriptan HCl Others
Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligan...
T84400 5-methyl Chrysene NSC 407620 Others
5-Methylchrysene, a carcinogenic polycyclic aromatic hydrocarbon with four fused rings, functions as an aryl hydrocarbon receptor agonist. It is generated through the incomplete combustion of organic matter and primarily...
T72430 L-Kynurenine sulfate Others
L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist, activates AHR-driven polarization of naive T cells towards the anti-inflammatory Treg phenotype.
T61244 AhR agonist 2 Others
AhR agonist 2 (Compound 12a) is a highly potent agonist of the aryl hydrocarbon receptor (AhR), exhibiting an EC50 value of 0.03 nM. This compound rapidly induces nuclear enrichment of AhR and initiates transcription of ...
T84540 AHR antagonist 7 Others
AHR antagonist 7 (compound 4j), a selective aryl hydrocarbon receptor (AhR) antagonist with high affinity, demonstrates a dissociation constant (K i) of 1.4 nM [1].
T63389 AHR antagonist 5 hemimaleate Others
AHR antagonist 5 hemimaleate is a potent antagonist (IC50 < 0.5 μM) of the orally active aryl hydrocarbon receptor (AHR). aHR antagonist 5 hemimaleate in combination with the detection site inhibitor anti-PD-1 exhibited ...
T79283 HCYP1B1-IN-1 Others
hCYP1B1-IN-1 (compound B18) is an inhibitor of hCYP1B1 with an IC50 value of 3.6 nM and also acts as an antagonist of the Aryl Hydrocarbon Receptor. This compound demonstrates favorable metabolic stability and good cell ...
T79436 AHR agonist 4 Aryl Hydrocarbon Receptor
AHR agonist 4 (compound 24e), as an Aryl hydrocarbon receptor (AHR) agonist, modulates the immune equilibrium between Th17/22 and Treg cells. It is a lead compound under investigation for anti-psoriasis drugs and demonst...
T60539 KG-548 Others
KG-548 is an ARNT/TACC3 disruptor as well as a HIF-1α inhibitor. KG-548 directly interferes with the formation of the ARNT/TACC3 complex by competitively binding the ARNT PAS-B domain with TACC3. ARNT is the aryl hydroca...
T78716 MKA031 Others
MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impe...
T84434 Kynurenic Acid hydrate KYNA Others
Kynurenic acid, an active metabolite of tryptophan, is synthesized through a kynurenine intermediate by kynurenine aminotransferases (KATs). It acts as an antagonist of both NMDA and AMPA receptors, as well as α7 nicotin...
T72056 KYN-101 Others
KYN-101 is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-medi...

Compounds

ITE
T7202
Synonym:
Target: AhR, Aryl Hydrocarbon Receptor
MeBIO
T21966
Synonym:
Target: GSK-3, Aryl Hydrocarbon Receptor, CDK
YL-109
T1960
Synonym:
Target: AhR, Aryl Hydrocarbon Receptor
PDM2
T4608
Synonym:
Target: AhR, Aryl Hydrocarbon Receptor
Prochloraz
T20625
Synonym: Sporgon,Prelude
Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal
GNF351
T15410
Synonym:
Target: Aryl Hydrocarbon Receptor
CH-223191
T2448
Synonym: CH 223191
Target: AhR, Aryl Hydrocarbon Receptor
BAY-218
T5622
Synonym: AHR antagonist 1
Target: AhR, Aryl Hydrocarbon Receptor
CAY 10465
T4607
Synonym: CAY10465,CAY10465 Exclusive
Target: AhR, Aryl Hydrocarbon Receptor
BAY 2416964
T10270
Synonym:
Target: Aryl Hydrocarbon Receptor
1,4-Chrysenequinone
T10007
Synonym: Chrysene-1,4-dione
Target: AhR
FICZ
TQ0257
Synonym: 6-Formylindolo[3,2-b]carbazole
Target: Aryl Hydrocarbon Receptor
StemRegenin 1
T1831
Synonym: SR1
Target: AhR, Aryl Hydrocarbon Receptor
5-fluoro 203
T21704
Synonym: 5F-203,NSC-703786
Target: Others
VAF347
T13276
Synonym:
Target: Aryl Hydrocarbon Receptor
PD98059
T2623
Synonym: PD 98059
Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy
Carbidopa monohydrate
T2148
Synonym: Carbidopa Hydrate,S(-)-Carbidopa
Target: Decarboxylase, Aryl Hydrocarbon Receptor
Benzyl butyl phthalate
T0640
Synonym: BBP,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate
Target: Others, Aryl Hydrocarbon Receptor
Pifithrin-α hydrobromide
T2707
Synonym: Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide
Target: Ferroptosis, Aryl Hydrocarbon Receptor, p53
SGA360
T8980
Synonym:
Target: Aryl Hydrocarbon Receptor
AHR antagonist 2
T10269
Synonym:
Target: Aryl Hydrocarbon Receptor
PDM11
T5541
Synonym: 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11
Target: AhR
ANI-7
T10325
Synonym:
Target: Chk
Pifithrin-β hydrobromide
T3637
Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)
Target: Ferroptosis, p53
β-NF-JQ1
T10526
Synonym:
Target: Others, PROTACs
10-Cl-BBQ
T24960
Synonym: 10ClBBQ
Target: Others
CHD-5
T25235
Synonym: CHD5
Target: Others
Benzyl 2-naphthyl ether
T20307
Synonym: AI3 00945,AI300945,AI3-00945
Target: Others
Mivotilate
T16082
Synonym: YH439
Target: Others
AHR-activator-1023
T23686
Synonym: Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023
Target: Others
AFP464 free base
T10258
Synonym: NSC710464 free base
Target: HIF
AHR antagonist 4
T10271
Synonym:
Target: Others
6,2',4'-Trimethoxyflavone
T22528
Synonym:
Target: Others
StemRegenin 1 (hydrochloride)
T23400
Synonym: StemRegenin 1 (hydrochloride) (1227633-49-9 free base)
Target: Others
DiMNF
T22725
Synonym:
Target: Others
AHR antagonist 5
T10272
Synonym:
Target: Others
MNF
T71938
Synonym:
Target: Others
AhR modulator-1
T10273
Synonym:
Target: Others
Avitriptan HCl
T70257
Synonym:
Target: Others
5-methyl Chrysene
T84400
Synonym: NSC 407620
Target: Others
L-Kynurenine sulfate
T72430
Synonym:
Target: Others
AhR agonist 2
T61244
Synonym:
Target: Others
AHR antagonist 7
T84540
Synonym:
Target: Others
AHR antagonist 5 hemimaleate
T63389
Synonym:
Target: Others
hCYP1B1-IN-1
T79283
Synonym:
Target: Others
AHR agonist 4
T79436
Synonym:
Target: Aryl Hydrocarbon Receptor
KG-548
T60539
Synonym:
Target: Others
MKA031
T78716
Synonym:
Target: Others
Kynurenic Acid hydrate
T84434
Synonym: KYNA
Target: Others
KYN-101
T72056
Synonym:
Target: Others
1 2
Cat No. Product Name Synonyms Targets
TN1451 Brevifolincarboxylic acid AhR , Aryl Hydrocarbon Receptor , Glucosidase
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 3...
T6795 Carbidopa (S)-(-)-Carbidopa,Lodosyn Decarboxylase , Aryl Hydrocarbon Receptor
Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.
T4928 L-Kynurenine (S)-Kynurenine AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ...
T0878 Diosmin Venosmine,Diosmil,Barosmin Aryl Hydrocarbon Receptor , Norepinephrine
Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.
T4644 Tapinarof GSK2894512,Benvitimod,WBI 1001 AhR , Aryl Hydrocarbon Receptor
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
TN2883 3',4'-Dimethoxyflavone Others , PARP
3',4'-Dimethoxyflavone is a reference standard for flavonoid compounds, which have a variety of medicinal activities.
T5281 Skatole Scatole,3-Methylindole,3-​Methylindole,3-Methyl-1H-indole,beta-Methylindole AhR , p38 MAPK , Aryl Hydrocarbon Receptor , Endogenous Metabolite , Antibacterial , Autophagy , Antifungal
Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
T4939 Indole-3-pyruvic acid 3-(3-Indolyl)-2-oxopropanoic acid Others
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmenta...
T2947 Indole-3-carbinol I3C,3-Indolemethanol,Indole-3-Methanol E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
TN6694 5,6-Benzoflavone β-Naphthoflavone,beta-NF Antioxidant
5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a...
T4938 Potassium 1H-indol-3-yl sulfate Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate AhR , Endogenous Metabolite
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm...
TN6366 Lupinalbin A
Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokine...
T75433 Norisoboldine hydrochloride Others
Norisoboldine hydrochloride, an orally active aryl hydrocarbon receptor (AhR) agonist and a prominent isoquinoline alkaloid found in Radix Linderae, is utilized for research purposes in the study of Rheumatoid Arthritis ...
T73402 Flavipin Others
Flavipin, an aryl hydrocarbon receptor (Ahr) agonist, activates Ahr downstream gene expression in mouse CD4+ T cells and CD11b+ macrophages. This compound disrupts the stabilizing effect of Arid5a on the newly identified...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00958 AHR Protein, Human, Recombinant (His) Human E. coli
AHR Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-00957 ARNT Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
ARNT Protein, Human, Recombinant (His) is expressed in Yeast.
TMPY-01709 HIF-1 alpha Protein, Human, Recombinant (His) Human E. coli
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (...

Isotope Products

Cat No. Product Name Synonyms Targets
T70313 Indoxyl Sulfate-d5 potassium salt
Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of in...
TargetMol