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Transforming Growth Factor-β Receptors, TGF-β Receptors

Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors that belong to TGF-β receptor family. They exist in several different isoforms that can be homo- or heterodimeric. TGF-β is a growth factor and cytokine involved in paracrine signalling and can be found in many different tissue types, including brain, heart, kidney, liver, bone, and testes. Over-expression of TGF-β can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease.

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Species
Canine (4)
Cynomolgus (6)
Human (32)
Mouse (16)
Rat (4)
Rhesus (3)
Expression System
Baculovirus-Insect Cells (5)
HEK293 (51)
Human Cells (9)
Tag
C-6His (1)
C-Fc (5)
C-Fc-6His (3)
C-mFc-Avi (4)
GST (2)
His (28)
Tag Free (1)
hFc (33)
Cat No. product name / Synonyms Species Expression System
TMPJ-00304 ALK-1 Protein, Mouse, Recombinant (hFc)
ALK-1 Protein, Mouse, Recombinant (hFc)
Mouse Human Cells
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenet...
TMPJ-00314 ACVR2B Protein, Human, Recombinant (hFc & His)
ACVR2B Protein, Human, Recombinant (hFc & His)
Human Human Cells
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor comple...
TMPJ-00315 ACVR2A Protein, Human, Recombinant (hFc & His)
ACVR2A Protein, Human, Recombinant (hFc & His)
Human Human Cells
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II rec...
TMPJ-00325 BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)
BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)
Human Human Cells
Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors...
TMPJ-00333 TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc)
TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc)
Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β re...
TMPJ-00334 TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)
TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)
Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β re...
TMPJ-01158 ALK-2/ACVR1 Protein, Human, Recombinant (hFc)
ALK-2/ACVR1 Protein, Human, Recombinant (hFc)
Human Human Cells
Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor fami...
TMPJ-01178 TGFBR1 Protein, Mouse, Recombinant (hFc)
TGFBR1 Protein, Mouse, Recombinant (hFc)
Mouse Human Cells
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms ...
TMPK-00305 TGFBR1 Protein, Human, Recombinant (mFc & Avi)
TGFBR1 Protein, Human, Recombinant (mFc & Avi)
Human HEK293
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpr...
TMPK-00306 TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated
Human HEK293
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpr...
TMPK-00328 TGFBR2 Protein, Human, Recombinant (mFc & Avi)
TGFBR2 Protein, Human, Recombinant (mFc & Avi)
Human HEK293
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t...
TMPK-00329 TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
Human HEK293
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t...
TMPY-00310 ALK-1 Protein, Cynomolgus, Recombinant (His)
ALK-1 Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (tr...
TMPY-00444 ALK-4/ACVR1B Protein, Mouse, Recombinant (hFc)
ALK-4/ACVR1B Protein, Mouse, Recombinant (hFc)
Mouse HEK293
ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and...
TMPY-00486 ALK-7 Protein, Human, Recombinant (hFc)
ALK-7 Protein, Human, Recombinant (hFc)
Human HEK293
ALK-7, also known as ALK7 and ACVR1C, belongs to the ALK family. It is a type I receptor for the TGFB family of signaling molecules. TGF-β is the prototype of a ...
TMPY-00614 BMPR1A/ALK-3 Protein, Canine, Recombinant (hFc)
BMPR1A/ALK-3 Protein, Canine, Recombinant (hFc)
Canine HEK293
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins...
TMPY-00650 ALK-1 Protein, Human, Recombinant (hFc)
ALK-1 Protein, Human, Recombinant (hFc)
Human HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (tr...
TMPY-00658 ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc)
ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc)
Human HEK293
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK...
TMPY-00659 ACVR2A Protein, Human, Recombinant (hFc)
ACVR2A Protein, Human, Recombinant (hFc)
Human HEK293
ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein o...
TMPY-00662 ALK-1 Protein, Mouse, Recombinant (His & hFc)
ALK-1 Protein, Mouse, Recombinant (His & hFc)
Mouse HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (tr...
ALK-1 Protein, Mouse, Recombinant (hFc)
TMPJ-00304
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenet...
ACVR2B Protein, Human, Recombinant (hFc & His)
TMPJ-00314
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor comple...
ACVR2A Protein, Human, Recombinant (hFc & His)
TMPJ-00315
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II rec...
BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)
TMPJ-00325
Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors...
TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc)
TMPJ-00333
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β re...
TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)
TMPJ-00334
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β re...
ALK-2/ACVR1 Protein, Human, Recombinant (hFc)
TMPJ-01158
Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor fami...
TGFBR1 Protein, Mouse, Recombinant (hFc)
TMPJ-01178
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms ...
TGFBR1 Protein, Human, Recombinant (mFc & Avi)
TMPK-00305
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpr...
TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TMPK-00306
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpr...
TGFBR2 Protein, Human, Recombinant (mFc & Avi)
TMPK-00328
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t...
TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TMPK-00329
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t...
ALK-1 Protein, Cynomolgus, Recombinant (His)
TMPY-00310
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (tr...
ALK-4/ACVR1B Protein, Mouse, Recombinant (hFc)
TMPY-00444
ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and...
ALK-7 Protein, Human, Recombinant (hFc)
TMPY-00486
ALK-7, also known as ALK7 and ACVR1C, belongs to the ALK family. It is a type I receptor for the TGFB family of signaling molecules. TGF-β is the prototype of a ...
BMPR1A/ALK-3 Protein, Canine, Recombinant (hFc)
TMPY-00614
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins...
ALK-1 Protein, Human, Recombinant (hFc)
TMPY-00650
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (tr...
ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc)
TMPY-00658
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK...
ACVR2A Protein, Human, Recombinant (hFc)
TMPY-00659
ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein o...
ALK-1 Protein, Mouse, Recombinant (His & hFc)
TMPY-00662
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (tr...
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