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GPCR/G Protein

Melanin-concentrating Hormone Receptor (MCHR)

(10)

Melanocortin Receptor

Neuropeptide Y Receptor

Prostaglandin Receptor

(181)

Protease-activated Receptor

Somatostatin

Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin inhibits insulin and glucagon secretion.

Filter Signaling PathwaysGPCR/G ProteinSomatostatin

Pasireotide Acetate
TP2207396091-76-2
Pasireotide Acetate is a stable cyclohexapeptide somatostatin mimic
- $97
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Cited
Seglitide acetate
T2874399248-33-6
Seglitide acetate (MK-678) is a selective agonist of sst2 somatostatin receptor.
- $195
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(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid
T776702919211-45-1
(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid is a potential SSTR4 agonist.
- $195
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L-796,778
T32511217480-25-6
L-796,778 is an SST3 agonist and a selective ligand of SST3, which can increase the level of cAMP in the body.
- $195
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Cortistatin 14, human, rat acetate
TP1188L
Cortistatin 14, human, rat acetate is a neuropeptide having structural similarity to somatostatin-14 and shows anticonvulsive, neuroprotective effects and remarkable anti-inflammatory properties. Cortistatin 14, human, rat acetate binds and exerts its fun
- $185
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Somatostatin 1-28 acetate
TP2124L
Somatostatin 1-28 acetate circulates in human plasma. Approximately 46% of the total somatostatin-like immunoreactivity in plasma is due to Somatostatin 1-28 acetate.
- $847
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Cortistatin-14 acetate
TP1570L
Cortistatin-14 acetate, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 acetate shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties
- $113
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Cyclosomatostatin Acetate
T21567L
Cyclosomatostatin Acetate is an effective antagonist of the somatostatin receptor.Cyclosomatostatin Acetate inhibits SSTR1 signaling and decreases cell proliferation, ALDH+ cell population size, and sphere-formation in colorectal cancer cells.
- $257
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BIM-23190 aceate
T39262L
BIM-23190 aceate, a somatostatin analog, a selective agonist of SSTR2 and SSTR5. BIM-23190 can be used in cancer and acromegaly studies.
- $195
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FK962
T7829283167-06-6
FK962 is an somatostatin release enhancer , exerts cognitive-enhancing actions.
- $51
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Octreotide
T258483150-76-9
Octreotide (SMS 201-995) is a potent inhibitor of growth hormone, glucagon, and insulin.
- $43
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L-796,778 acetate
T32511L
L-796,778 acetate is a slective somatostatin receptor agonist with IC50 of 24nM for sst3, for sst1, sst2, sst4 and sst5, IC50 is >1000nM.
- $195
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Paltusotine
T96922172870-89-0
Paltusotine is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability. Paltusotine maintains GH and IGF-1 levels in acromegaly patients
- $178
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CYN 154806 TFA
TP13462828432-46-6
CYN 154806 TFA is a cyclic octapeptide and an effective selective somatostatin sst2 receptor antagonist. For the recombinant sst2, sst1, sst3, sst4 and sst5 receptors, the pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48, respectively.
- $147
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L-803087
T11800217480-26-7
L-803087 is a potent and selective agonist of the growth inhibitor sst4 receptor with a Ki value of 0.7 nM for sst4, which is more than 280-fold more selective than other growth inhibitory receptors.L-803087 induced AMPA-mediated synaptic responses in the hippocampus in vitro, and in vivo increased seizures in alginate-induced seizure-busting mice.
- $198
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2-Aminoethanethiol
T108060-23-1
2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
- $45
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Somatostatin acetate
TP1302L
Somatostatin acetate is an endogenously secreted inhibitor of cell proliferation with potential antitumor activity for the study of cancer and neurological disorders.
- $54
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Cortistatin-14
TP1570186901-48-4
Cortistatin-14, a neuropeptide structurally similar to growth inhibitor-14, has anticonvulsant and neuroprotective effects and impairs recognition memory consolidation in mice through activation of sst(2), growth hormone-releasing peptide, and GABA(A/B) receptor, which can be used to study sepsis-induced cognitive impairment.
- $98
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Octreotide Acetate
T411979517-01-4
Octreotide Acetate (Sandostatin) is a potent, long-acting synthetic somatostatin octapeptide analog that inhibits secretion of growth hormone.
- $30
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