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Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3198 Pre-084 138847-85-5
Pre-084
Pre-084 is a high affinity, selective σ1 agonist.
T4620 Siramesine 147817-50-3
Siramesine
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent ant...
T78086 S1R agonist 1 hydrochloride 242487-82-7 98%
S1R agonist 1 hydrochloride
S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprote...
T78087 S1R agonist 2 hydrochloride 98%
S1R agonist 2 hydrochloride
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects aga...
T78734 Sigma-1 receptor antagonist 5 98%
Sigma-1 receptor antagonist 5
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors (...
T78915 AD186 98%
AD186
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R. Notably, AD186 completely reverses the anti...
T78916 AB21 oxalate 98%
AB21 oxalate
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively. It effectively reduces ...
T79356 SARS-CoV-2-IN-57 1265624-68-7 98%
SARS-CoV-2-IN-57
SARS-CoV-2-IN-57 (compound (+)-R-26) is a potent inhibitor of SARS-CoV-2 with an IC50 of 80 nM and demonstrates high affinity for the Sigma Receptor, exhibiting ...
T79666 WLB-89462 2849471-75-4 98%
WLB-89462
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-in...
T74813 Sigma-1 receptor antagonist 4 T74813 98%
Sigma-1 receptor antagonist 4
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-induced ana...
T19342 Glycerol phenylbutyrate-D5 T19342 98%
Glycerol phenylbutyrate-D5
Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T19341 Glycerol phenylbutyrate-D15 T19341 98%
Glycerol phenylbutyrate-D15
Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T16445 PD 144418 154130-99-1 98%
PD 144418
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for...
T4111 Blarcamesine hydrochloride 195615-84-0 99.95%
Blarcamesine hydrochloride
Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).
T77340L AB21 HCl 99.89%
AB21 HCl
AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce ...
T0678 Amitriptyline hydrochloride 549-18-8 99.87%
Amitriptyline hydrochloride
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive ...
T12910 Sigma-1 receptor antagonist 1 1639220-19-1 99.81%
Sigma-1 receptor antagonist 1
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity ...
T15393 Glycerol phenylbutyrate 611168-24-2 99.74%
Glycerol phenylbutyrate
Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T9244 σ1 Receptor antagonist-1 1204401-49-9 99.68%
σ1 Receptor antagonist-1
σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.
T5027 Dimemorfan phosphate 36304-84-4 99.67%
Dimemorfan phosphate
Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.
Pre-084
T3198
Pre-084 is a high affinity, selective σ1 agonist.
Siramesine
T4620
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent ant...
S1R agonist 1 hydrochloride
T78086
S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprote...
S1R agonist 2 hydrochloride
T78087
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects aga...
Sigma-1 receptor antagonist 5
T78734
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors (...
AD186
T78915
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R. Notably, AD186 completely reverses the anti...
AB21 oxalate
T78916
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively. It effectively reduces ...
SARS-CoV-2-IN-57
T79356
SARS-CoV-2-IN-57 (compound (+)-R-26) is a potent inhibitor of SARS-CoV-2 with an IC50 of 80 nM and demonstrates high affinity for the Sigma Receptor, exhibiting ...
WLB-89462
T79666
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-in...
Sigma-1 receptor antagonist 4
T74813
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-induced ana...
Glycerol phenylbutyrate-D5
T19342
Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
Glycerol phenylbutyrate-D15
T19341
Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
PD 144418
T16445
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for...
Blarcamesine hydrochloride
T4111
Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).
AB21 HCl
T77340L
AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce ...
Amitriptyline hydrochloride
T0678
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive ...
Sigma-1 receptor antagonist 1
T12910
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity ...
Glycerol phenylbutyrate
T15393
Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
σ1 Receptor antagonist-1
T9244
σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.
Dimemorfan phosphate
T5027
Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.
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TargetMol