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Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.
Cat. No. Product name CAS No. Purity Chemical Structure
T4620 Siramesine 147817-50-3 98%
Siramesine(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer acti...
T1865 S1RA 878141-96-9 98%
S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
T19341 Glycerol phenylbutyrate-D15 T19341 98%
Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T16445 PD 144418 154130-99-1 98%
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for...
T19342 Glycerol phenylbutyrate-D5 T19342 98%
Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T12912 Sigma-1 receptor antagonist 3 1639220-17-9 98%
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
T12911 Sigma-1 receptor antagonist 2 1639220-15-7 98%
Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).
T22904 L-745870 trihydrochloride 866021-03-6 98%
highly potent and selective D4 dopamine receptor antagonist
T21788 BD 1008 dihydrobromide 138356-09-9
BD1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD1008 dihydrobromide have high affinity for sigma1 receptors, moderate...
T1180 Blonanserin 132810-10-7 100%
Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability prof...
T15034 Roluperidone 359625-79-9 97.77%
Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
T5969 Ditolylguanidine 97-39-2 98%
Ditolylguanidine is an agonist of sigma receptor (σ1/σ2 receptor).
T20797 NE-100 hydrochloride  149409-57-4 98.85%
NE100 HCl is a potent and selective antagonist of sigma-1 receptor.
T3597 Cutamesine dihydrochloride 165377-44-6 99%
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced...
T4596 4-IBP 155798-08-6 99.12%
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
T8834 EST64454 hydrochloride 1950569-11-5 99.15%
EST64454 is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
T7488 BD1063 dhydrochloride 206996-13-6 99.33%
BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
T1740 BD-1047 dihydrobromide 138356-21-5 99.39%
BD-1047 hydrobromide, a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.
T7952 Noscapine 128-62-1 99.43%
Noscapine is a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma.
T3198L PRE-084 hydrochloride 75136-54-8 99.61%
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
Siramesine
T4620
Siramesine(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer acti...
S1RA
T1865
S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
Glycerol phenylbutyrate-D15
T19341
Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
PD 144418
T16445
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for...
Glycerol phenylbutyrate-D5
T19342
Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
Sigma-1 receptor antagonist 3
T12912
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
Sigma-1 receptor antagonist 2
T12911
Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).
L-745870 trihydrochloride
T22904
highly potent and selective D4 dopamine receptor antagonist
BD 1008 dihydrobromide
T21788
BD1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD1008 dihydrobromide have high affinity for sigma1 receptors, moderate...
Blonanserin
T1180
Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability prof...
Roluperidone
T15034
Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
Ditolylguanidine
T5969
Ditolylguanidine is an agonist of sigma receptor (σ1/σ2 receptor).
NE-100 hydrochloride 
T20797
NE100 HCl is a potent and selective antagonist of sigma-1 receptor.
Cutamesine dihydrochloride
T3597
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced...
4-IBP
T4596
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
EST64454 hydrochloride
T8834
EST64454 is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
BD1063 dhydrochloride
T7488
BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
BD-1047 dihydrobromide
T1740
BD-1047 hydrobromide, a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.
Noscapine
T7952
Noscapine is a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma.
PRE-084 hydrochloride
T3198L
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
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