Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.

Cat. No.	Product name	CAS No.	Purity
T3198	Pre-084	138847-85-5
T3198	Pre-084 is a high affinity, selective σ1 agonist.
T4620	Siramesine	147817-50-3
T4620	Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent ant...
T78086	S1R agonist 1 hydrochloride	242487-82-7	98%
T78086	S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprote...
T78087	S1R agonist 2 hydrochloride		98%
T78087	Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects aga...
T78734	Sigma-1 receptor antagonist 5		98%
T78734	Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors (...
T78915	AD186		98%
T78915	AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R. Notably, AD186 completely reverses the anti...
T78916	AB21 oxalate		98%
T78916	AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively. It effectively reduces ...
T79356	SARS-CoV-2-IN-57	1265624-68-7	98%
T79356	SARS-CoV-2-IN-57 (compound (+)-R-26) is a potent inhibitor of SARS-CoV-2 with an IC50 of 80 nM and demonstrates high affinity for the Sigma Receptor, exhibiting ...
T79666	WLB-89462	2849471-75-4	98%
T79666	WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-in...
T19342	Glycerol phenylbutyrate-D5	T19342	98%
T19342	Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T19341	Glycerol phenylbutyrate-D15	T19341	98%
T19341	Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T16445	PD 144418	154130-99-1	98%
T16445	PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for...
T4111	Blarcamesine hydrochloride	195615-84-0	99.95%
T4111	Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).
T77340L	AB21 HCl		99.89%
T77340L	AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce ...
T12910	Sigma-1 receptor antagonist 1	1639220-19-1	99.81%
T12910	Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity ...
T9244	σ1 Receptor antagonist-1	1204401-49-9	99.68%
T9244	σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.
T5027	Dimemorfan phosphate	36304-84-4	99.67%
T5027	Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.
T4229	S1RA hydrochloride	1265917-14-3	99.65%
T4229	S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1...
T22240	Amitriptyline	50-48-6	99.64%
T22240	Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neurop...
T3198L	PRE-084 hydrochloride	75136-54-8	99.61%
T3198L	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).