T16771 |
RO-5963
|
1416663-77-8
|
98%
|
|
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
|
T11931 |
MA242
|
1049704-18-8
|
98%
|
|
MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).
|
TN4341 |
IVHD-valtrate
|
28325-56-6
|
98%
|
|
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
|
T14203 |
AM-8735
|
1429386-01-5
|
98%
|
|
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
|
T12040 |
Milademetan
|
1398568-47-2
|
98%
|
|
Milademetan is a specific and oral inhibitor of MDM2.
|
T12027 |
MG-277
|
T12027
|
98%
|
|
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
|
TN4107 |
Ganoderic acid X
|
86377-53-9
|
98%
|
|
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
|
T12031 |
MI-1061
|
1410737-34-6
|
98%
|
|
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
|
T16888 |
SJ-172550
|
431979-47-4
|
98%
|
|
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
|
T67698 |
WAY-300374
|
350678-63-6
|
98%
|
|
WAY-300374 inhibits the p53-MDM2 protein-protein interaction.
|
T6254 |
Idasanutlin
|
1229705-06-9
|
98%
|
|
Idasanutlin (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
|
T1919 |
Tenovin-1
|
380315-80-0
|
98%
|
|
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
|
T3184 |
Kevetrin hydrochloride
|
66592-89-0
|
98%
|
|
Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
|
T21773 |
SP-141
|
1253491-42-7
|
98%
|
|
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
|
T6610 |
NSC-207895
|
58131-57-0
|
98%
|
|
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
|
TQ0231 |
NVP-CGM097
|
1313363-54-0
|
98%
|
|
NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
|
T3517 |
RO8994
|
1309684-94-3
|
98%
|
|
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
|
TQ0127 |
Navtemadlin
|
1352066-68-2
|
98%
|
|
AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
|
T6614 |
Nutlin-3b
|
675576-97-3
|
98%
|
|
Nutlin-3b is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nu...
|
T14303 |
Alrizomadlin
|
1818393-16-6
|
98%
|
|
Alrizomadlin is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and i...
|