T16771 |
RO-5963
|
1416663-77-8
|
98%
|
|
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
|
TN4107 |
Ganoderic acid X
|
86377-53-9
|
98%
|
|
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
|
T14203 |
AM-8735
|
1429386-01-5
|
98%
|
|
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
|
T6585 |
SAR405838
|
1303607-60-4
|
98%
|
|
MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
|
T67698 |
WAY-300374
|
350678-63-6
|
98%
|
|
WAY-300374 inhibits the p53-MDM2 protein-protein interaction.
|
T11931 |
MA242
|
1049704-18-8
|
98%
|
|
MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).
|
T12040 |
Milademetan
|
1398568-47-2
|
98%
|
|
Milademetan is a specific and oral inhibitor of MDM2.
|
TN1805 |
Isosilybin B
|
142796-22-3
|
98%
|
|
Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway, it has anti-prostate cancer (PCA) activit...
|
T12031 |
MI-1061
|
1410737-34-6
|
98%
|
|
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
|
TQ0127 |
Navtemadlin
|
1352066-68-2
|
98%
|
|
AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
|
T12027 |
MG-277
|
T12027
|
98%
|
|
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
|
TN4341 |
IVHD-valtrate
|
28325-56-6
|
98%
|
|
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
|
T28509 |
RDR03871
|
286008-51-3
|
98%
|
|
RDR03871 is an MDM2 inhibitor.
|
T9698 |
UC2288
|
1394011-91-6
|
98%
|
|
UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein sta...
|
T11980 |
MD-224
|
2136247-12-4
|
100%
|
|
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
|
T2243 |
Serdemetan
|
881202-45-5
|
98%
|
|
Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
|
T16523L |
PhiKan 083
|
880813-36-5
|
98.2%
|
|
PhiKan 083 is a carbazole derivative
|
T2179 |
Triptolide
|
38748-32-2
|
98.52%
|
|
Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
|
T14303 |
Alrizomadlin
|
1818393-16-6
|
98.69%
|
|
Alrizomadlin is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and i...
|
T6614 |
Nutlin-3b
|
675576-97-3
|
98.83%
|
|
Nutlin-3b is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nu...
|