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LRRK2

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79746 LRRK2-IN-10 2704562-80-9 98%
LRRK2-IN-10
LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS9...
T81785 MK-1468 2769107-89-1 98%
MK-1468
MK-1468, a highly selective and brain-penetrant LRRK2 inhibitor, exhibits an IC50 of 0.8 nM and is utilized in the study of Parkinson's disease [1].
T2014 CCG-1423 285986-88-1 99.98%
CCG-1423
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
T6031 GNE0877 1374828-69-9 99.96%
GNE0877
GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
T16512 PFE-360 1527475-61-1 99.91%
PFE-360
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
T2240 GSK2578215A 1285515-21-0 99.81%
GSK2578215A
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T11878 LRRK2 inhibitor 1 1802525-61-6 99.73%
LRRK2 inhibitor 1
LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.
T1945 GNE-7915 1351761-44-8 99.7%
GNE-7915
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
T2050 PF-06447475 1527473-33-1 99.62%
PF-06447475
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
T6176 IKK 16 873225-46-8 99.61%
IKK 16
IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
T2022 CZC-54252 1191911-27-9 99.39%
CZC-54252
CZC-54252 is a potent inhibitor of LRRK2.
T16115 MLi-2 1627091-47-7 99.33%
MLi-2
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a ...
T6057 URMC-099 1229582-33-5 99.32%
URMC-099
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T5139 CZC-25146 hydrochloride 1330003-04-7 99.06%
CZC-25146 hydrochloride
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
T1770 GNE-9605 1536200-31-3 98.55%
GNE-9605
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
T2246 LRRK2-IN-1 1234480-84-2 98.44%
LRRK2-IN-1
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
T39202 CZC-54252 hydrochloride 1784253-05-9 98.21%
CZC-54252 hydrochloride
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuropr...
T3053 CZC-25146 1191911-26-8 98.2%
CZC-25146
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat ki...
T7729 PF-06454589 1527473-30-8 96.29%
PF-06454589
PF-06454589 is a potent inhibitor of LRRK2.
T7155 JH-II-127 1700693-08-8
JH-II-127
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
LRRK2-IN-10
T79746
LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS9...
MK-1468
T81785
MK-1468, a highly selective and brain-penetrant LRRK2 inhibitor, exhibits an IC50 of 0.8 nM and is utilized in the study of Parkinson's disease [1].
CCG-1423
T2014
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
GNE0877
T6031
GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
PFE-360
T16512
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
GSK2578215A
T2240
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
LRRK2 inhibitor 1
T11878
LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.
GNE-7915
T1945
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
PF-06447475
T2050
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
IKK 16
T6176
IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
CZC-54252
T2022
CZC-54252 is a potent inhibitor of LRRK2.
MLi-2
T16115
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a ...
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
CZC-25146 hydrochloride
T5139
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
GNE-9605
T1770
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
LRRK2-IN-1
T2246
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
CZC-54252 hydrochloride
T39202
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuropr...
CZC-25146
T3053
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat ki...
PF-06454589
T7729
PF-06454589 is a potent inhibitor of LRRK2.
JH-II-127
T7155
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
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TargetMol