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Carbonic Anhydrase

The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). The active site of most carbonic anhydrases contains a zinc ion. They are therefore classified as metalloenzymes. The enzyme maintains acid-base balance and helps transport carbon dioxide.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0037 Halazone 80-13-7 90%
Halazone
Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.
T78729 HCAIX/VII-IN-1 98%
hCAIX/VII-IN-1
hCAIX/VII-IN-1 is a selective inhibitor of human carbonic anhydrase isoforms VII and IX. It displays inhibitory activity against hCA I, II, IV, VII, and IX, with...
T78789 HCA XII-IN-6 98%
hCA XII-IN-6
Compound 4d, known as hCA XII-IN-6, is a potent inhibitor of human carbonic anhydrase XII (hCA XII) with a Ki value of 84.2 nM and exhibits anti-proliferative ef...
T78840 Carbonic anhydrase inhibitor 15 98%
Carbonic anhydrase inhibitor 15
Carbonic Anhydrase Inhibitor 15 (Compound 8), with an inhibitory constant (K_i) of 8.5 nM for hCA II, exhibits analgesic effects [1].
T79411 HCAXII-IN-7 98%
hCAXII-IN-7
hCAXII-IN-7 (compound 6e) functions as an inhibitor of human carbonic anhydrase XII (hCA XII) and possesses blood-brain barrier (BBB) permeability. Moreover, it ...
T79451 WES-1 2748673-86-9 98%
WES-1
WES-1 (Compound 8g), a carbonic anhydrase IX inhibitor (Ki: 55.9 μM), exhibits broad-spectrum antiproliferative activity against various cancer cell lines, inclu...
T79540 HCA/VEGFR-2-IN-1 98%
hCA/VEGFR-2-IN-1
hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual inhibitor targeting both Carbonic Anhydrase (CA) IX/XII and Vascular Endothelial Growth Factor Receptor 2 (VEGFR...
T79681 CA inhibitor 2 98%
CA inhibitor 2
Compound 4H is a potent carbonic anhydrase inhibitor with an IC50 value of 0.033 μM [1].
T79748 HCAIX/XII-IN-7 98%
hCAIX/XII-IN-7
Compound 3e (hCAIX/XII-IN-7) is a potent inhibitor of human carbonic anhydrase (hCA) isozymes IX and XII, displaying inhibitory constants (Kis) of 503.7 nM for h...
T79753 HCAIX/XII-IN-8 59994-64-8 98%
hCAIX/XII-IN-8
hCAIX/XII-IN-8 (compound 3g) is a potent inhibitor of the human carbonic anhydrases (CAs) IX and XII, with inhibition constants (K i) of 8.5 nM for CA IX and 6.7...
T83137 ALP/Carbonic anhydrase-IN-1 2091887-74-8 98%
ALP/Carbonic anhydrase-IN-1
Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkaline ...
T72122 Carbonic anhydrase inhibitor 12 2883451-38-3 98%
Carbonic anhydrase inhibitor 12
Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and ...
T73028 HCAIX-IN-16 2849348-38-3 98%
hCAIX-IN-16
hCAIX-IN-16 (Compound 12d), an inhibitor of hCA IX, exhibits inhibition constants (K i) of 190.0 nM for hCA IX and 187.9 nM for hCA XII. It can arrest the cell c...
T73029 HCAIX-IN-15 2849348-43-0 98%
hCAIX-IN-15
hCAIX-IN-15 is a potent inhibitor of human carbonic anhydrase IX (hCA IX) with an inhibition constant (Ki) of 38.8 nM, exhibiting broad-spectrum anticancer activ...
TN6707 Methyl 2,4-dihydroxybenzoate 2150-47-2 99.98%
Methyl 2,4-dihydroxybenzoate
Methyl 2,4-dihydroxybenzoate is a natural product.
T2187 Orthanilamide 3306-62-5 99.96%
Orthanilamide
Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.
T0106 Methazolamide 554-57-4 99.96%
Methazolamide
Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
T0267 Zonisamide 68291-97-4 99.94%
Zonisamide
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carboni...
T8827 EMAC10101d 2561476-24-0 99.92%
EMAC10101d
compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an i...
T8611 2,3-dihydro-1H-indene-5-sulfonamide 35203-93-1 99.89%
2,3-dihydro-1H-indene-5-sulfonamide
2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.
Halazone
T0037
Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.
hCAIX/VII-IN-1
T78729
hCAIX/VII-IN-1 is a selective inhibitor of human carbonic anhydrase isoforms VII and IX. It displays inhibitory activity against hCA I, II, IV, VII, and IX, with...
hCA XII-IN-6
T78789
Compound 4d, known as hCA XII-IN-6, is a potent inhibitor of human carbonic anhydrase XII (hCA XII) with a Ki value of 84.2 nM and exhibits anti-proliferative ef...
Carbonic anhydrase inhibitor 15
T78840
Carbonic Anhydrase Inhibitor 15 (Compound 8), with an inhibitory constant (K_i) of 8.5 nM for hCA II, exhibits analgesic effects [1].
hCAXII-IN-7
T79411
hCAXII-IN-7 (compound 6e) functions as an inhibitor of human carbonic anhydrase XII (hCA XII) and possesses blood-brain barrier (BBB) permeability. Moreover, it ...
WES-1
T79451
WES-1 (Compound 8g), a carbonic anhydrase IX inhibitor (Ki: 55.9 μM), exhibits broad-spectrum antiproliferative activity against various cancer cell lines, inclu...
hCA/VEGFR-2-IN-1
T79540
hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual inhibitor targeting both Carbonic Anhydrase (CA) IX/XII and Vascular Endothelial Growth Factor Receptor 2 (VEGFR...
CA inhibitor 2
T79681
Compound 4H is a potent carbonic anhydrase inhibitor with an IC50 value of 0.033 μM [1].
hCAIX/XII-IN-7
T79748
Compound 3e (hCAIX/XII-IN-7) is a potent inhibitor of human carbonic anhydrase (hCA) isozymes IX and XII, displaying inhibitory constants (Kis) of 503.7 nM for h...
hCAIX/XII-IN-8
T79753
hCAIX/XII-IN-8 (compound 3g) is a potent inhibitor of the human carbonic anhydrases (CAs) IX and XII, with inhibition constants (K i) of 8.5 nM for CA IX and 6.7...
ALP/Carbonic anhydrase-IN-1
T83137
Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkaline ...
Carbonic anhydrase inhibitor 12
T72122
Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and ...
hCAIX-IN-16
T73028
hCAIX-IN-16 (Compound 12d), an inhibitor of hCA IX, exhibits inhibition constants (K i) of 190.0 nM for hCA IX and 187.9 nM for hCA XII. It can arrest the cell c...
hCAIX-IN-15
T73029
hCAIX-IN-15 is a potent inhibitor of human carbonic anhydrase IX (hCA IX) with an inhibition constant (Ki) of 38.8 nM, exhibiting broad-spectrum anticancer activ...
Methyl 2,4-dihydroxybenzoate
TN6707
Methyl 2,4-dihydroxybenzoate is a natural product.
Orthanilamide
T2187
Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.
Methazolamide
T0106
Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Zonisamide
T0267
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carboni...
EMAC10101d
T8827
compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an i...
2,3-dihydro-1H-indene-5-sulfonamide
T8611
2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.
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TargetMol