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Carbonic Anhydrase

The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). The active site of most carbonic anhydrases contains a zinc ion. They are therefore classified as metalloenzymes. The enzyme maintains acid-base balance and helps transport carbon dioxide.
Cat. No. Product name CAS No. Purity Chemical Structure
T34093 PNNP 330-13-2 98%
pNNP can be used as a substrate for the PP2C assay. pNNP inhibits β-carbonic anhydrase and α-carbonate dehydrogenase, as well as H. pylori Helicobacter pylori. p...
T38808 Cyclamic acid sodium 139-05-9 98%
Cyclamic acid sodium is a carbonic anhydrase inhibitor and one of the most widely used artificial sweeteners in food and pharmaceuticals.Cyclamic acid sodium sho...
T77560 2-Amino-4-(4-chlorophenyl)thiazole 2103-99-3 98%
2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE is a 2-aminothiazole derivative. 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE inhibited hCA I, hCA II, AChE and BChE with Ki values of 0...
T68136 5-Hexenoic acid, 6-[4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]phenyl]-6-(3-pyridinyl)- 133276-52-5 98%
5-Hexenoic acid, 6-[4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]phenyl]-6-(3-pyridinyl)- shows activity against Carbonic anhydrase and Cyclooxygenase 2.
T67775 Enpp/Carbonic anhydrase-IN-1 2883495-35-8 98%
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00,...
T6581 Methyclothiazide 135-07-9 98%
Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
T0515 Tioxolone 4991-65-5 98%
Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
T23782 Benzolamide 3368-13-6 98%
Benzolamide is an inhibitor of carbonic anhydrase. Benzolamide inhibits low-threshold calcium currents in hippocampal pyramidal neurons.
T61745 HCAI/II-IN-6 694466-00-7 98%
hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki valu...
T0738 Urea 57-13-6 98%
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
T0675 Topiramate 97240-79-4 98%
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepat...
T36758 CAIX Inhibitor S4 1330061-67-0 98%
CAIX Inhibitor S4 is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM...
T21294 Polmacoxib 301692-76-2 98%
Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant col...
T2S0357 6-Hydroxycoumarin 6093-68-1 98%
6-Hydroxycoumarin exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a hu...
T6469 Dichlorphenamide 120-97-8 98%
Dichlorphenamide is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
T73177 HCAII-IN-9 2878477-18-8 98%
hCAII-IN-9 is a potent carbonic anhydrase inhibitor that inhibits hCA II, hCA IX, and hCA XII with IC50s of 1.18 μM and 0.17 μM , and 2.99 μM , respectively. hCA...
T9323 4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide 654-62-6 98%
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide is a carbonic anhydrase inhibitor, used as a potential anti-tumor and antiglaucoma drug.
T25372 EMD57033 147527-31-9 98%
EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to pro...
T6781 Benzenesulfonamide 98-10-2 98%
Benzenesulfonamide ia an inhibitor of carbonic anhydrases.
T2134 Dorzolamide hydrochloride 130693-82-2 98%
Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid co...
pNNP
T34093
pNNP can be used as a substrate for the PP2C assay. pNNP inhibits β-carbonic anhydrase and α-carbonate dehydrogenase, as well as H. pylori Helicobacter pylori. p...
Cyclamic acid sodium
T38808
Cyclamic acid sodium is a carbonic anhydrase inhibitor and one of the most widely used artificial sweeteners in food and pharmaceuticals.Cyclamic acid sodium sho...
2-Amino-4-(4-chlorophenyl)thiazole
T77560
2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE is a 2-aminothiazole derivative. 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE inhibited hCA I, hCA II, AChE and BChE with Ki values of 0...
5-Hexenoic acid, 6-[4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]phenyl]-6-(3-pyridinyl)-
T68136
5-Hexenoic acid, 6-[4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]phenyl]-6-(3-pyridinyl)- shows activity against Carbonic anhydrase and Cyclooxygenase 2.
Enpp/Carbonic anhydrase-IN-1
T67775
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00,...
Methyclothiazide
T6581
Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
Tioxolone
T0515
Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
Benzolamide
T23782
Benzolamide is an inhibitor of carbonic anhydrase. Benzolamide inhibits low-threshold calcium currents in hippocampal pyramidal neurons.
hCAI/II-IN-6
T61745
hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki valu...
Urea
T0738
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
Topiramate
T0675
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepat...
CAIX Inhibitor S4
T36758
CAIX Inhibitor S4 is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM...
Polmacoxib
T21294
Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant col...
6-Hydroxycoumarin
T2S0357
6-Hydroxycoumarin exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a hu...
Dichlorphenamide
T6469
Dichlorphenamide is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
hCAII-IN-9
T73177
hCAII-IN-9 is a potent carbonic anhydrase inhibitor that inhibits hCA II, hCA IX, and hCA XII with IC50s of 1.18 μM and 0.17 μM , and 2.99 μM , respectively. hCA...
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
T9323
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide is a carbonic anhydrase inhibitor, used as a potential anti-tumor and antiglaucoma drug.
EMD57033
T25372
EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to pro...
Benzenesulfonamide
T6781
Benzenesulfonamide ia an inhibitor of carbonic anhydrases.
Dorzolamide hydrochloride
T2134
Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid co...
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