Search Result

Search Results for " vasodilatory "

Compounds

Natural Products

Libraries

Cat No.	Product Name	Synonyms	Targets
T7656	Apelin-13
	Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ...
T0075	Nicorandil	SG-75	Potassium Channel
	Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly b...		Potassium Channel
T1410	Torsemide	AC-4464,JDL-464,Torasemide	Na-K-Cl cotransporter
	Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h...		Na-K-Cl cotransporter
T3518	GSK269962A	GSK269962B,GSK 269962,GSK269962A HCl	ROCK , S6 Kinase
	GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.		ROCK , S6 Kinase
T15471	Hepronicate	Megrin	Others
	Hepronicate（Megrin） is a small molecule compound with hypolipidemic and vasodilatory activity.		Others
T27323	FK-453	FK453,FK 453	Adenosine Receptor
	FK-453 is a potent antagonist of non-xanthine adenosine A1 receptor with diuretic and renal vasodilatory activity.		Adenosine Receptor
T13684	Equilin	7-Dehydroestrone	Calcium Channel
	Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity that increases monocyte-endothelial adhesion through NF-κB signalling.Equilin similarly relaxes mesenteric arterial resistance by...		Calcium Channel
T68083L	Dl-Ibuterol hydrochloride	dl-Ibuterol hydrochloride (53034-85-8 Free base),dl-Ibuterol HCl,Ibuterol HCl	Others
	dl-Ibuterol hydrochloride (Ibuterol HCl) has vasodilatory activity and can be used to study asthma and bronchospasm.		Others
T0370	Pheniramine maleate	Daneral,Inhiston,Trimetose	5-HT Receptor , Histamine Receptor
	Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re...		5-HT Receptor , Histamine Receptor
T14064	8-Bromo-cGMP sodium		Calcium Channel , PKA
	8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimula...		Calcium Channel , PKA
T8135	Minoxidil sulfate	Minoxidil sulphate,U-58838	Potassium Channel
	Minoxidil sulfate (U-58838) is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil.		Potassium Channel
T1398	Tadalafil	Cialis,IC-351	Apoptosis , PDE
	Tadalafil (IC-351) is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGM...		Apoptosis , PDE
T36033	DETA NONOate	NOC-18,Diethylamine NONOate	NO Synthase
	DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infect...		NO Synthase
T68138	Saterinone		Adrenergic Receptor , PDE
	Saterinone is a potent and selective phosphodiesterase III inhibitor and a potent antagonist of the vascular α-1-adrenoceptor. Saterinone has vasodilatory properties and can be used in the acute treatment of chronic hear...		Adrenergic Receptor , PDE
T1158	Phenoxybenzamine hydrochloride	NCI-c01661,NSC 37448,Phenoxybenzamine HCl	CaMK , Adrenergic Receptor
	Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non...		CaMK , Adrenergic Receptor
T71376	Tzc 5665
	Tzc 5665 is a pyridazinone derivative with vasodilatory and beta-adrenergic blocking activities and type III phosphodiesterase inhibitory action.
T69123	NSC-2488
	NSC-2488 is a novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.
T69132	NSC-4231
	NSC-4231 is a novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.
T69142	NSC-2888
	NSC-2888 is a Novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.
T71377	Oberadilol
	Oberadilol is a pyridazinone derivative with vasodilatory and beta-adrenergic blocking activities and type III phosphodiesterase inhibitory action
T76189	Phyllomedusin
	Phyllomedusin, a tachykinin decapeptide, acts as an NK1 receptor agonist. It exhibits vasodilatory effects and induces pyloric contractions [1] [2] [3].
T37459	Lipoxin A5
	Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes. LXA5 slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4. However, LXA5 does not exe...
T14967	Cimlanod	BMS-986231,CXL-1427	Others
	Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the...		Others
T39519	GSK269962A hydrochloride	GSK 269962 hydrochloride
	GSK269962A hydrochloride (GSK 269962 hydrochloride) is a highly potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.6 nM and 4 nM, respectively, for recombinant human isoforms. This compound exhibits both anti-inf...
T82932	Auriculin B	Atrial natriuretic peptide(126-150)(rat),ANP (126-150) (Rat)
	Auriculin B (ANP (126-150) (Rat)), a rat-derived atrial natriuretic peptide, exhibits potent vasodilatory and diuretic properties [1].
T28391	PF-9404C	PF9404C
	PF-9404C is the S-S diesteroisomer of a beta adrenergic receptors blocker with vasodilatory properties. PF9404C increased the formation of cyclic GMP from 3 pmol mg−1 protein in basal conditions, to 53 pmol mg−1 protein ...
T36566	Amauromine
	Amauromine is a neutral antagonist of the cannabinoid (CB) receptor CB1 that is selective for CB1 (Ki = 178 nM; Kb = 66.6 nM) over CB2, with no activity at CB2 receptors at concentrations up to 10 μM. It is also an antag...
T82217	Helospectin I
	Helospectin I, a neuropeptide belonging to the vasoactive intestinal peptide (VIP) family, exhibits vasodilatory and antihypertensive properties, effectively reducing blood pressure. It was initially isolated from the sa...
T82216	Helospectin II
	Helospectin II, a member of the vasoactive intestinal peptide (VIP) family, exhibits vasodilatory and antihypertensive properties that reduce blood pressure. This neuropeptide was initially isolated from the venom of the...
T62004	(Rac)-Nebivolol
	(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective antagonist of β1-adrenergic receptor (IC 50= 0.8 nM). Nebivolol shows Vasodilatory activity. In the early stages of ethanol-ind...
T83164	Adrenomedullin (porcine)
	Adrenomedullin (porcine) is a vasodilatory peptide that elicits endothelium-dependent relaxation in rat aorta at an IC50 of 2.4 nM and also induces endothelium-independent relaxation in porcine coronary arteries, with an...
T73083	Nipradolol	KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351
	Nipradolol (KT-210; K-351), an alpha-1-adrenergic receptor antagonist, effectively inhibits the elevation of intraocular pressure (IOP) induced by Phenylephrine in an albino rabbit model and suppresses noradrenaline (NA)...
TP2000	MM 07
	Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in...
T36405	Pro-Adrenomedullin (153-185), human	Pro-Adrenomedullin (153-185), human,H2N-Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu-OH
	Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaec...
T35876	Chlorthalidone Impurity G
	Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotran...

Compounds

Target: Potassium Channel

Torsemide

T1410

Synonym: AC-4464,JDL-464,Torasemide

Target: Na-K-Cl cotransporter

GSK269962A

T3518

Synonym: GSK269962B,GSK 269962,GSK269962A HCl

Target: ROCK, S6 Kinase

Synonym: FK453,FK 453

Target: Adenosine Receptor

Equilin

T13684

Synonym: 7-Dehydroestrone

Target: Calcium Channel

dl-Ibuterol hydrochloride

T68083L

Synonym: dl-Ibuterol hydrochloride (53034-85-8 Free base),dl-Ibuterol HCl,Ibuterol HCl

Target: Others

Pheniramine maleate

T0370

Synonym: Daneral,Inhiston,Trimetose

Target: 5-HT Receptor, Histamine Receptor

8-Bromo-cGMP sodium

T14064

Synonym:

Target: Calcium Channel, PKA

Minoxidil sulfate

T8135

Synonym: Minoxidil sulphate,U-58838

Target: Potassium Channel

Tadalafil

T1398

Synonym: Cialis,IC-351

Target: Apoptosis, PDE

DETA NONOate

T36033

Synonym: NOC-18,Diethylamine NONOate

Target: Adrenergic Receptor, PDE

Phenoxybenzamine hydrochloride

T1158

Synonym: NCI-c01661,NSC 37448,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Synonym: BMS-986231,CXL-1427

Target: Others

GSK269962A hydrochloride

T39519

Synonym: GSK 269962 hydrochloride

Target:

Auriculin B

T82932

Synonym: Atrial natriuretic peptide(126-150)(rat),ANP (126-150) (Rat)

Adrenomedullin (porcine)

Synonym: KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351

Pro-Adrenomedullin (153-185), human

T36405

Synonym: Pro-Adrenomedullin (153-185), human,H2N-Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu-OH

Target:

Chlorthalidone Impurity G

T35876

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T7437	3-(3-Hydroxyphenyl)propionic Acid	m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid	Others , Endogenous Metabolite
	3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) is one of the major metabolites of ingested caffeic acid.it inhibited osteoclastogenesis and bone osteoclastic resorptive activity.		Others , Endogenous Metabolite
T0853	Adenosine	D-Adenosine,Adenine riboside	Apoptosis , Nucleoside Antimetabolite/Analog , Endogenous Metabolite , Autophagy
	Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
T3904	Gomisin J		Calcium Channel , AMPK
	Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK...		Calcium Channel , AMPK
TN1393	(-)-Anonaine		Apoptosis , Antioxidant , Parasite , Antifungal
	(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces ...		Apoptosis , Antioxidant , Parasite , Antifungal
T3011	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid	Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine	Others , Endogenous Metabolite
	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (3-Anthraniloylalanine) is a ketone and an amino acid derivative with diverse biological functions, including vasodilatory, immunoregulatory and neuromodulatory activities. 2-...		Others , Endogenous Metabolite
T3794	Pentagalloylglucose	Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose	Influenza Virus
	1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses poten...		Influenza Virus
TN2533	1-Hydroxy-2,3,4,7-tetramethoxyxanthone		5-HT Receptor
	1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-...		5-HT Receptor
T78468	Yohimbic acid hydrate
	Yohimbic acid hydrate, an amphoteric demethylated derivative of Yohimbine, exhibits vasodilatory properties and is utilized in osteoarthritis (OA) research [1] [2] [3].

Natural Products

3-(3-Hydroxyphenyl)propionic Acid

T7437

Synonym: m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid

Target: Others, Endogenous Metabolite

Adenosine

T0853

Synonym: D-Adenosine,Adenine riboside

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Endogenous Metabolite, Autophagy

Gomisin J

T3904

Synonym:

Target: Calcium Channel, AMPK

(-)-Anonaine

TN1393

Synonym:

Target: Apoptosis, Antioxidant, Parasite, Antifungal

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

T3011

Synonym: Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine

Target: Others, Endogenous Metabolite

Pentagalloylglucose

T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose

Target: Influenza Virus

1-Hydroxy-2,3,4,7-tetramethoxyxanthone

TN2533

Synonym:

Target: 5-HT Receptor

Yohimbic acid hydrate

T78468

Synonym:

Target:

Cat No.	Product Name
L6110	Alkaloid Natural Product Library		468 compounds
	A unique collection of 468 natural alkaloids can be used for high throughput and high content screening；

Libraries

Alkaloid Natural Product Library

L6110

Compounds: 468