p 27

p27 is a CDK inhibitor and a substrate of SCFSkp2/Cks1, useful for cancer research.

p27 Analogue CP2 is a macrocyclic peptide inhibitor that targets the SCFSkp2/Cks1 E3 ubiquitin ligase complex (Kd=32 nM). By preventing the ubiquitination and subsequent degradation of the p27 protein mediated by SCFSkp2/Cks1, it helps restore p27 levels and inhibits cell proliferation. This compound shows potential for research on cancers that rely on Skp2 overexpression, such as breast cancer.

SJ572403 is an inhibitor of disordered protein p27 with Kd of 2.2 mM for specific regions within the D2 subdomain of p27-KID. SJ572403 can be used in studies about diseases with intrinsically disordered proteins.

Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.

P-gp inhibitor 27 (Compound D2) is an inhibitor of P-glycoprotein (P-gp) that reduces the expression of P-gp and MRP1. It increases the accumulation of Rh123 in A2780/T cells and reverses multidrug resistance to Paclitaxel (EC50 of 88 nM) and Cisplatin.

27-trans-p-Coumaroyloxyursolic acid and 27-cis-p-coumaroyloxyursolic acid show potent inhibitory activity in the acyl CoA cholesteryl acyl transferase (ACAT) assay.

3β-Hydroxy-27-p-Z-coumaroyloxyurs-12-en-28-oic acid (compound 8) is a triterpene ester HIV-1 protease inhibitor with potential for use in antiretroviral combination therapy for AIDS.

Anti-Mouse IL-27p28 Antibody (MM27.7B1) is an IgG2a, κ inhibitor antibody derived from mice, designed to target and inhibit mouse IL-27p28.

R-PEP 27 is an inhibitor of potent renin, decreased plasma angiotensin II, and blood pressure in normal volunteers.

Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.

Talmapimod (SCIO-469) is a selective, orally active, ATP-competitive p38α inhibitor with IC50 values of 9 nM for p38α and 90 nM for p38β. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 kinases, including other MAPKs.

CYM50260 is a potent and highly selective agonist of the sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM), exhibiting no activity against S1P1-R, S1P2-R, S1P3-R, and S1P5-R.

Tolnaftate (NP-27) is a synthetic antifungal agent used to treat skin infections caused by fungi.

Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.

Riviciclib is a potent inhibitor of cyclin-dependent kinase (CDK)(CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively),with antitumor activity on cisplatin-resistant cells.

CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM) by blocking ubiquitin transfer to substrates, for use in cancer research.

PUN00551, also known as Pyrenebutyricamide-PEG5-amine, TFA salt, is a compound formed by the combination of pyridine and PEG-amine. PUN00551 exhibits specific properties in carboxylic acid coupling, making it useful for synthesizing dyes and nanotubes. As it currently lacks an official name, a provisional code name has been assigned according to MedKoo chemical naming conventions [refer to webpage: https://www.medkoo.com/page/naming] for ease of communication.

Doxorubicinol is the major circulating metabolite of doxorubicin with antineoplastic acitivity.

TP-271, a tetracyclines antibiotic, is used potentially for the treatment of community-acquired bacterial pneumonia (CABP).

VTP-27999, an alkyl amine Renin inhibitor, has been utilized in trials studying the basic science of Renal Function.

3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of gamma-aminobutyric acid (GABA), acts as a potent and selective agonist of the GABA B receptor.

VTP-27999 HCl is an alkyl amine renin inhibitor, useful for treating hypertension and end-organ diseases. IC50 value: Target: Renin.

TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).

Orphenadrine Citrate (Flexon) is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.