orai

Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.

Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor that distinguishes between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) and has an IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells.

Anti-Orai1 Antibody is a human-derived antibody expressed in CHO, targeting Orai1. It possesses a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. For isotype control, refer to HumanIgG2kappa, Isotype Control.

Sophoraisoflavone A is a potential MRP inhibitor; it is also an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tube growth at 1.25 ug/disc. Sophoraisoflavone A shows inhibitory effects on copper-induced prot

Chlorothalonil (DAC 2787) is a broad-spectrum fungicide with high efficiency and low toxicity. Chlorothalonil is widely used to control various pests such as fruit trees and vegetable leaves. Chlorothalonil also has good control effects on various diseases such as rice, wheat, and cotton.

Aurora inhibitor 1 is a potent inhibitor of Aurora A and Aurora B kinases with IC50 values of ≤ 4 nM and ≤ 13 nM, respectively.

NorA-IN-2 (compound DZ-3) is a potent inhibitor of NorA. It exhibits activity as a NorA efflux pump inhibitor (EPI).

Jamaicin (AnCoA4), an isoflavone derived from the chickweed plant, is an inhibitor of the STIM1-Orai1 channel that blocks calcium influx, reduces its interaction with STIM1, and inhibits T-cell activation.

Zatosetron is a serotonin antagonists.

NorA-IN-1 is a NorA efflux inhibitor, which can be used to study overcoming multidrug resistance based on microbial efflux transporter proteins.

RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.

Zegocractin (CM-4620) is an inhibitor of calcium-release activated calcium (CRAC) channels.

Ferroptosisinducer-7 is an orally active and selective inducer of ferroptosis, operating through the inositol 1,4,5-trisphosphate receptor (IP3R)/ORAI calcium release-activated calcium channel protein. This compound significantly alleviates anemia, inhibits bone marrow CTL activation, and improves hematopoietic function in immune-mediated bone marrow failure. It is utilized in research on aplastic anemia.