bacterium

trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations.

Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.

Mycobacterium Tuberculosis-IN-6 (compound b1) is an inhibitor of the enoyl reductase InhA from Mycobacterium tuberculosis, with an IC50 value of 7.74 μM. It is useful in antibacterial research.

Mycobacterium Tuberculosis-IN-7 (Compound 4c) inhibits M. tuberculosis H37Ra with an MIC of 5.34 μg/mL and exhibits mild cytotoxicity against cancer cells Vero, A549, and HepG2 (IC50 > 50 μM).

Mycobacterium Tuberculosis-IN-8 (Compound 6g) is a selective inhibitor of Mycobacterium tuberculosis (MTB), with a MIC value of 6.25 µg/mL against MTB H37Rv. It demonstrates potent antitubercular activity by inhibiting mycolic acid biosynthesis, which is crucial for maintaining bacterial cell wall integrity. Mycobacterium Tuberculosis-IN-8 holds potential for research in antitubercular agents.

Mycobacterium Tuberculosis-IN-2 (Compound 29) acts as a potent bacterial inhibitor specifically targeting Mycobacterium Tuberculosis, making it useful for tuberculosis research (MIC = 0.07-0.16 μM) [1].

Mycobacterium Tuberculosis-IN-5 (Compound 11) is the hydrochloride salt form of 5-Fluoroindole. It acts as an antimicrobial agent effective against Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of 29.1 μM. This compound demonstrates metabolic stability in rat liver microsomes and exhibits antitubercular activity in mice.

Mycobacterium bovisbacterialprotein is a member of Mycobacterium tuberculosis, responsible for causing tuberculosis in cattle.

Exo-α-1,2-Fucosidase, derived from Bifidobacterium bifidum, is a glycoside hydrolase capable of releasing free fucose.

Phosphopantetheine adenylyltransferase, Mycobacterium tuberculosis (EC 2.7.7.3), facilitates the fourth reaction in the biosynthesis of coenzyme A. Coenzyme A is integral to various metabolic pathways, particularly in the synthesis of components of the mycobacterial cell wall.

Polyphosphate Kinase, originating from Propionibacterium shermanii (EC 2.7.4.1), facilitates the reversible transfer of phosphate groups between polyphosphates and ATP. The phosphorylation of ADP to ATP by Polyphosphate Kinase occurs in a sequential manner, with polyphosphate remaining attached to the enzyme until the reaction is complete.

exo-α-Arabinofuranosidase, Microbacterium esteraromaticum (EC.3.2.1.55), is a glycoside hydrolase enzyme.

AU1235 is a Mycobacterium tuberculosis inhibitor.

Sapienic acid sodium is a fatty acid with variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity.

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp. It exhibits selective antibacterial activity against Xanthomonas species, inhibiting Xanthomonas citri, Xanthomonas oryzae, and phage with MIC values of 0.4 μg/mL, 12.5 μg/mL, and 12.5 μg/mL respectively.

SY-640 is an Acetamide derivative. SY-640 exhibits potent hepatoprotective effect. SY-640 reduces liver injury in mice induced by Propionibacterium acnes and Lipopolysaccharide.

GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis), effective against multidrug-resistant (MDR), extensively drug-resistant (XDR), and drug-sensitive (DS) strains. It inhibits the growth of human macrophages with an IC50 value of 0.07 μM.

Cefsulodin sodium (Sulcephalosporin) hydrate is a β lactam antibiotic.

Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.

Methyl quinoline-2-carboxylate (Methyl 2-quinolinecarboxylate) inhibits the binding of Mycobacterium tuberculosis.

Thiacetazone (Diazam) is a thiosemicarbazone that thioacetazone treatment of pulmonary tuberculosis

Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.

ML406 shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition(IC50 : 30 nM)

Lansoprazole Sulfide-D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide (T21128) is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole.