aeruginosa

Lipopolysaccharides from P. aeruginosa (Pseudomonas aeruginosa) 10 are endotoxins and TLR4 activators that originate from the bacterium P. aeruginosa 10, classified as S-type LPS. They exhibit a characteristic tripartite structure: an O antigen, a core oligosaccharide, and lipid A. The lipopolysaccharides from P. aeruginosa 10 are distinct due to their unique fatty acid composition, an unusually high level of phosphorylation (identified as triphosphate residues), and a distinctive outer region in the core oligosaccharide. Moreover, their O-specific side chains are typically rich in novel amino sugars. These lipopolysaccharides display susceptibility to viruses, with their viral sensitivity being influenced by the molecular weight polysaccharide content. A reduction in high-molecular-weight polysaccharides increases their sensitivity to bacteriophages.

Pipemidic acid (Acido pipemidico), a new antibacterial agent, inhibits the activity of Pseudomonas aeruginosa.

(Z)-2-decenoic acid (cis-dec-2-enoic acid) is an unsaturated short-chain fatty acid secreted by Pseudomonas aeruginosa. It can induce a dispersion response in biofilms formed by gram-negative and gram-positive bacteria and can also inhibit biofilm development.

Zidebactam (WCK-5107) is a β-lactamase inhibitor and a penicillin-binding protein 2 (PBP2) inhibitor (IC50 = 0.26 μg/ml), with enzymatic inhibitory activity, and can be used for antibacterial research.

Cefsulodin sodium (Sulcephalosporin) hydrate is a β lactam antibiotic.

Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria.

Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco. It is a close analog of Sclareol, a plant antifungal compound.

Avibactam sodium (NXL-104) is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases (IC50=8/80/38 nM) covalently and reversibly. Avibactam sodium has antimicrobial activity and can be used to treat urinary tract infections.

Moxalactam sodium salt (LY-127935) is an antibiotic compound more effective against Escherichia coli and Pseudomonas aeruginosathan cephalosporins.

Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a fourth-generation fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.

D-Menthol ((+)-MENTHOL) is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neurite, suggests that menthol inhibits α±7-nACh receptors in a noncompetitive manner.

CysHHC10 acetate shows antibacterial activities against both Gram-positive and Gram-negative bacteria with MIC of 10.1, 20.2, 2.5, and 1.3 mM for E. coli, P. aeruginosa, S. aureus, and S. epidermidis, respectively.

SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.

Zidebactam sodium salt is a potent inhibitor of β-lactamase, and also is an inhibitor of penicillin-binding protein2 (PBP2)(IC50 of 0.26 μg/mL).

4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].

BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively[1][2]. BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against multiresistant gram-negative bacilli

Temafloxacin (Omniflox) is an antibiotic and antimycobacterial agent. It used to treat lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.

1-Palmitoyl Lysophosphatidic Acid is an analog of LPA and improves the the action of ampicillin, piperacillin, and ceftazidime on various strains of P. aeruginosa via binding both Ca2+ and Mg2+.

Propargylcholine (Propargylcholine (bromide)) is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.

Relebactam (MK-7655) is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases.

MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.

HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by increasing ROS levels, and damaging cell

Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.