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Search Result

Search Results for " sag "

Targets

Hedgehog/Smoothened Smo

26

Compounds

6

Natural Products

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T1779 SAG Smoothened Agonist (SAG) HCl,Smoothened Agonist Hedgehog/Smoothened , Smo
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.
T40465 SAG dihydrochloride Hedgehog/Smoothened
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo.
T35559 SAG 21k Hedgehog/Smoothened
SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.
T4211 SAG hydrochloride (912545-86-9(free base)) Smoothened Agonist HCl Hedgehog/Smoothened
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
T24754 Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5 Hedgehog/Smoothened
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies...
T20845 Kopexil Mexoryl SAG,Aminexil
Kopexil, an N-oxide, is used to treat hair loss.
T24159 IHR-1 IHR 1 Smo
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
T23027 MRT-10 Hedgehog/Smoothened
MRT-10 is a Smoothened (Smo) receptor antagonist.
T6962 Rasagiline Mesylate TVP1012,AGN1135,Azilect Apoptosis , MAO , Autophagy , Monoamine Oxidase
Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.
T17044 Tesaglitazar PPAR
Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0...
T1119 Rasagiline AGN1135,TVP1012 BCL , MAO , Monoamine Oxidase
Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.
T12693 Rasagiline 13C3 mesylate racemic TVP1012 13C3 racemic,AGN1135 13C3 racemic Others
Rasagiline 13C3 mesylate racemic is the deuterium labeled Rasagiline, which is an irreversible monoamine oxidase inhibitor.
T8683 Mipsagargin G-202 Others
Mipsagargin (G-202) is a new antibiotic that inhibits DNA biosynthesis.
T28995 Tosagestin Org 30659,Org30659,Org-30659
Tosagestin is a progesterone receptor agonist.
T82346 Galanin message associated peptide (1-41) amide
Galanin message-associated peptide (1-41) amide is a peptide hormone [1].
T36903 Rasagiline-13C3 (mesylate) Rasagiline-13C3 (mesylate)
Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is se...
T71910 Racemic rasagiline
Racemic rasagiline, also known as AGN-1135, is a Monoamine Oxidase type-B inhibitor (MAOI). However, application of this drug can lead to fatal hypertensive crisis in patients who consume tyramine-rich foods. TVP-102...
T13252 (S)-Rasagiline TVP1022,S-PAI Others
(S)-Rasagiline is rasagiline S-isomer, and is an agent of anti-Parkinson.
T80981 Tisagenlecleucel CTL019
Tisagenlecleucel (CTL019), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, selectively targets and eradicates CD19-expressing B cells, and is utilized in the study of refractory aggressive diffuse...
T16273 Napsagatran hydrate Ro 46-6240/010 hydrate,Ro 46-6240 hydrate Others
Napsagatran hydrate is a novel and specific inhibitor of thrombin.
T13252L (S)-Rasagiline mesylate TVP1022 (mesylate),S-PAI mesylate Others
(S)-Rasagiline mesylate is rasagiline S-isomer, and is an agent of anti-Parkinson.
T69480 Sagopilone
Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymeri...
T124794 Kokusaginine
Kokusaginine is a useful organic compound for research related to life sciences and the catalog number is T124794.
T22089 HPI 1 Hedgehog/Smoothened
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a...
T11070L DO34 Others
DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG).
T35562 Nat-20(S)-yne
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which bin...

Compounds

SAG
T1779
Synonym: Smoothened Agonist (SAG) HCl,Smoothened Agonist
Target: Hedgehog/Smoothened, Smo
SAG dihydrochloride
T40465
Synonym:
Target: Hedgehog/Smoothened
SAG 21k
T35559
Synonym:
Target: Hedgehog/Smoothened
SAG hydrochloride (912545-86-9(free base))
T4211
Synonym: Smoothened Agonist HCl
Target: Hedgehog/Smoothened
Hh-Ag1.5
T24754
Synonym: SAG-1.5,SAG1.5,SAG 1.5
Target: Hedgehog/Smoothened
Kopexil
T20845
Synonym: Mexoryl SAG,Aminexil
Target:
IHR-1
T24159
Synonym: IHR 1
Target: Smo
MRT-10
T23027
Synonym:
Target: Hedgehog/Smoothened
Rasagiline Mesylate
T6962
Synonym: TVP1012,AGN1135,Azilect
Target: Apoptosis, MAO, Autophagy, Monoamine Oxidase
Tesaglitazar
T17044
Synonym:
Target: PPAR
Rasagiline
T1119
Synonym: AGN1135,TVP1012
Target: BCL, MAO, Monoamine Oxidase
Rasagiline 13C3 mesylate racemic
T12693
Synonym: TVP1012 13C3 racemic,AGN1135 13C3 racemic
Target: Others
Mipsagargin
T8683
Synonym: G-202
Target: Others
Tosagestin
T28995
Synonym: Org 30659,Org30659,Org-30659
Target:
Galanin message associated peptide (1-41) amide
T82346
Synonym:
Target:
Rasagiline-13C3 (mesylate)
T36903
Synonym: Rasagiline-13C3 (mesylate)
Target:
Racemic rasagiline
T71910
Synonym:
Target:
(S)-Rasagiline
T13252
Synonym: TVP1022,S-PAI
Target: Others
Tisagenlecleucel
T80981
Synonym: CTL019
Target:
Napsagatran hydrate
T16273
Synonym: Ro 46-6240/010 hydrate,Ro 46-6240 hydrate
Target: Others
(S)-Rasagiline mesylate
T13252L
Synonym: TVP1022 (mesylate),S-PAI mesylate
Target: Others
Sagopilone
T69480
Synonym:
Target:
Kokusaginine
T124794
Synonym:
Target:
HPI 1
T22089
Synonym:
Target: Hedgehog/Smoothened
DO34
T11070L
Synonym:
Target: Others
Nat-20(S)-yne
T35562
Synonym:
Target:
Cat No. Product Name Synonyms Targets
TN4259 Iso-sagittatoside A Others
Iso-sagittatoside A is a natural product for research related to life sciences. The catalog number is TN4259 and the CAS number is 503456-08-4.
TN4932 Sageone PARP , Akt , Caspase , Antifection
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.Sageone also shows antiviral activity.
TQ0163 Sagittatoside A Icariin-A Estrogen/progestogen Receptor
Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
T81482 Physagulide J
Physagulide J, a withanolide compound extracted from Physalis angulata L., exhibits anti-inflammatory and anti-tumor properties [1].
TN2168 Sagittatoside C Others
Sagittatoside C is a natural product
TQ0168 Sagittatoside B Others
Sagittatoside B is a natural product from Epimedium brevicornu Maxim.

Natural Products

Iso-sagittatoside A
TN4259
Synonym:
Target: Others
Sageone
TN4932
Synonym:
Target: PARP, Akt, Caspase, Antifection
Sagittatoside A
TQ0163
Synonym: Icariin-A
Target: Estrogen/progestogen Receptor
Physagulide J
T81482
Synonym:
Target:
Sagittatoside C
TN2168
Synonym:
Target: Others
Sagittatoside B
TQ0168
Synonym:
Target: Others

Recombinant Proteins

Species：
Bovine (2)
Human (2)
Sus scrofa (Pig) (2)
Expression System：
E. coli (3)
HEK293 (1)
Yeast (1)
in vitro E. coli expression system (1)
Tag：
N-terminal 6xHis-tagged (2)
N-terminal 6xHis-GST-tagged (1)
N-terminal 6xHis-KSI-tagged (1)
N-terminal GST-tagged (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPH-02060 SAG Protein, Human, Recombinant (His) Human Yeast
SAG Protein, Human, Recombinant (His) is expressed in Yeast.
TMPY-02683 CSAG1 Protein, Human, Recombinant (hFc) Human HEK293
CSAG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 35.2 kDa. Accession number: Q6PB30-1
TMPH-03123 Rhodopsin Protein, Pig, Recombinant (GST & His) Sus scrofa (Pig) E. coli
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change t...
TMPH-00299 Rhodopsin Protein, Bovine, Recombinant (His) Bovine in vitro E. coli expression system
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change t...
TMPH-00300 Rhodopsin Protein, Bovine, Recombinant (His & KSI) Bovine E. coli
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change t...
TMPH-03124 Rhodopsin Protein, Pig, Recombinant (GST) Sus scrofa (Pig) E. coli
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change t...
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